Thioflavone is a heterocyclic compound containing a sulfur atom and a benzopyran ring system. It has been synthesized through various methods, including the reaction of 2-chlorobenzaldehyde with thiophenol in the presence of a base. Thioflavone exhibits fluorescence properties, particularly in its aggregated form, and has been widely studied as a probe for amyloid fibril formation. Its ability to bind to amyloid structures, such as those found in Alzheimer's disease, makes it valuable for studying the aggregation process and developing potential therapeutic agents. Thioflavone's fluorescence properties are also utilized in other applications, including the detection of metal ions and the development of fluorescent sensors. Its ability to interact with proteins and other biomolecules makes it a promising candidate for further research in various fields, including bioimaging, drug discovery, and materials science.'
thioflavone: has antineoplastic activity; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 69914 |
| CHEMBL ID | 58311 |
| SCHEMBL ID | 1374464 |
| MeSH ID | M0572597 |
| Synonym |
|---|
| 784-62-3 |
| 2-phenyl-thiochromen-4-one |
| bdbm50073409 |
| inchi=1/c15h10os/c16-13-10-15(11-6-2-1-3-7-11)17-14-9-5-4-8-12(13)14/h1-10 |
| 2-phenyl-4h-thiochromen-4-one |
| 4h-1-benzothiopyran-4-one, 2-phenyl- |
| thioflavone |
| CHEMBL58311 , |
| 2-phenylthiochromen-4-one |
| 2-phenyl-4h-1-benzothiopyran-4-one |
| unii-5821r1qe5h |
| 5821r1qe5h , |
| AKOS015889358 |
| 4h-1-benzothiopyran-4-one,2-phenyl- |
| thioflavone, 1- |
| SCHEMBL1374464 |
| DTXSID8061139 |
| 2-phenyl-4h-thiochromen-4-one # |
| 4h-benzothiopyran-4-one, 2-phenyl- |
| GIQPSSZMIZARDW-UHFFFAOYSA-N |
| Q27261542 |
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Capsid scaffolding protein | Human herpesvirus 5 strain AD169 | IC50 (µMol) | 34.0000 | 9.0000 | 9.0000 | 9.0000 | AID161712 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID208876 | Effective dose against 50% reduction in Human CNS tumor (TE671) cell number after 3-day incubation; - indicates inactive | 1996 | Journal of medicinal chemistry, May-10, Volume: 39, Issue:10 | Antitumor agents. 166. Synthesis and biological evaluation of 5,6,7,8-substituted-2-phenylthiochromen-4-ones. |
| AID8465 | Effective dose against 50% reduction in Human lung carcinoma (A-549) cell number after 3-day incubation. | 1996 | Journal of medicinal chemistry, May-10, Volume: 39, Issue:10 | Antitumor agents. 166. Synthesis and biological evaluation of 5,6,7,8-substituted-2-phenylthiochromen-4-ones. |
| AID161712 | Inhibitory activity against human cytomegalovirus (HCMV) protease was evaluated | 1998 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 8, Issue:24 | Benzothiopyran-4-one based reversible inhibitors of the human cytomegalovirus (HCMV) protease. |
| AID95344 | Effective dose against 50% reduction in Human epidermoid carcinoma of the nasopharynx (KB) cell number after 3-day incubation; - indicates inactive | 1996 | Journal of medicinal chemistry, May-10, Volume: 39, Issue:10 | Antitumor agents. 166. Synthesis and biological evaluation of 5,6,7,8-substituted-2-phenylthiochromen-4-ones. |
| AID150350 | Effective dose against 50% reduction in Murine leukemia (P-388) cell number after 3-day incubation; - indicates inactive | 1996 | Journal of medicinal chemistry, May-10, Volume: 39, Issue:10 | Antitumor agents. 166. Synthesis and biological evaluation of 5,6,7,8-substituted-2-phenylthiochromen-4-ones. |
| AID78814 | Effective dose against 50% reduction in Human ileocecal carcinoma (HCT-8) cell number after 3-day incubation. | 1996 | Journal of medicinal chemistry, May-10, Volume: 39, Issue:10 | Antitumor agents. 166. Synthesis and biological evaluation of 5,6,7,8-substituted-2-phenylthiochromen-4-ones. |
| AID167037 | Effective dose against 50% reduction in Human melanoma (RPMI)cell number after 3-day incubation; - indicates inactive | 1996 | Journal of medicinal chemistry, May-10, Volume: 39, Issue:10 | Antitumor agents. 166. Synthesis and biological evaluation of 5,6,7,8-substituted-2-phenylthiochromen-4-ones. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (50.00) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.50) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 1 (16.67%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 5 (83.33%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||