Compounds > sesterstatin 5
Page last updated: 2024-11-12

sesterstatin 5

Description

sesterstatin 5: sesterterpene isolated from the marine sponge Hyrtios erecta; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID10362737
CHEMBL ID291862
MeSH IDM0299914

Synonyms (3)

Synonym
sesterstatin 5
CHEMBL291862
(4s,5as,5br,7as,11as,11br,13r,13as)-5b,8,8,11a,13a-pentamethyl-4,5,5a,6,7,7a,9,10,11,11b,12,13-dodecahydrophenanthro[2,1-e][2]benzofuran-4,13-diol
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (21)

Assay IDTitleYearJournalArticle
AID469934Antimicrobial activity against methicillin resistant Mycobacterium intracellular ATCC 230682009Journal of natural products, Aug, Volume: 72, Issue:8
Scalarane sesterterpenoids: semisynthesis and biological activity.
AID469933Antimicrobial activity against methicillin resistant Staphylococcus aureus ATCC 433002009Journal of natural products, Aug, Volume: 72, Issue:8
Scalarane sesterterpenoids: semisynthesis and biological activity.
AID403377Growth inhibition of human FADU cells2005Journal of natural products, Aug, Volume: 68, Issue:8
Antineoplastic agents. 542. Isolation and structure of sesterstatin 6 from the Indian Ocean sponge Hyrtios erecta.
AID469931Cytotoxicity against human BT549 cells after 48 hrs by Neutral red assay2009Journal of natural products, Aug, Volume: 72, Issue:8
Scalarane sesterterpenoids: semisynthesis and biological activity.
AID403373Growth inhibition of human U251 cells2005Journal of natural products, Aug, Volume: 68, Issue:8
Antineoplastic agents. 542. Isolation and structure of sesterstatin 6 from the Indian Ocean sponge Hyrtios erecta.
AID167042Inhibitory activity against growth of human melanomic cancer cell line RPMI-7951 was determined1998Bioorganic & medicinal chemistry letters, Aug-18, Volume: 8, Issue:16
Antineoplastic agents. 397: Isolation and structure of sesterstatins 4 and 5 from Hyrtios erecta (the Republic of Maldives).
AID469930Cytotoxicity against human SK-MEL cells after 48 hrs by Neutral red assay2009Journal of natural products, Aug, Volume: 72, Issue:8
Scalarane sesterterpenoids: semisynthesis and biological activity.
AID469929Cytotoxicity against human SKOV3 cells after 48 hrs by Neutral red assay2009Journal of natural products, Aug, Volume: 72, Issue:8
Scalarane sesterterpenoids: semisynthesis and biological activity.
AID143027Inhibitory activity against growth of human lung NSC cancer cell line NCI-H460 was determined1998Bioorganic & medicinal chemistry letters, Aug-18, Volume: 8, Issue:16
Antineoplastic agents. 397: Isolation and structure of sesterstatins 4 and 5 from Hyrtios erecta (the Republic of Maldives).
AID403370Growth inhibition of mouse P388 cells2005Journal of natural products, Aug, Volume: 68, Issue:8
Antineoplastic agents. 542. Isolation and structure of sesterstatin 6 from the Indian Ocean sponge Hyrtios erecta.
AID214228Inhibitory activity against growth of human CNS cancer cell line U251 was determined1998Bioorganic & medicinal chemistry letters, Aug-18, Volume: 8, Issue:16
Antineoplastic agents. 397: Isolation and structure of sesterstatins 4 and 5 from Hyrtios erecta (the Republic of Maldives).
AID57738Inhibitory activity against growth of human prostate cancer cell line DU-145 was determined.1998Bioorganic & medicinal chemistry letters, Aug-18, Volume: 8, Issue:16
Antineoplastic agents. 397: Isolation and structure of sesterstatins 4 and 5 from Hyrtios erecta (the Republic of Maldives).
AID153663Effective dose that causes inhibition of growth of P388 leukemia cells was determined1998Bioorganic & medicinal chemistry letters, Aug-18, Volume: 8, Issue:16
Antineoplastic agents. 397: Isolation and structure of sesterstatins 4 and 5 from Hyrtios erecta (the Republic of Maldives).
AID403376Growth inhibition of human NCI-H460 cells2005Journal of natural products, Aug, Volume: 68, Issue:8
Antineoplastic agents. 542. Isolation and structure of sesterstatin 6 from the Indian Ocean sponge Hyrtios erecta.
AID68935Inhibitory activity against growth of human pharynx cancer cell line FADU was determined1998Bioorganic & medicinal chemistry letters, Aug-18, Volume: 8, Issue:16
Antineoplastic agents. 397: Isolation and structure of sesterstatins 4 and 5 from Hyrtios erecta (the Republic of Maldives).
AID403372Growth inhibition of human RPMI7951 cells2005Journal of natural products, Aug, Volume: 68, Issue:8
Antineoplastic agents. 542. Isolation and structure of sesterstatin 6 from the Indian Ocean sponge Hyrtios erecta.
AID403371Growth inhibition of human BxPC3 cells2005Journal of natural products, Aug, Volume: 68, Issue:8
Antineoplastic agents. 542. Isolation and structure of sesterstatin 6 from the Indian Ocean sponge Hyrtios erecta.
AID40029Inhibitory activity against growth of human pancreatic cancer cell line BXPC-3 was determined1998Bioorganic & medicinal chemistry letters, Aug-18, Volume: 8, Issue:16
Antineoplastic agents. 397: Isolation and structure of sesterstatins 4 and 5 from Hyrtios erecta (the Republic of Maldives).
AID469932Cytotoxicity against african green monkey Vero cells after 48 hrs by Neutral red assay2009Journal of natural products, Aug, Volume: 72, Issue:8
Scalarane sesterterpenoids: semisynthesis and biological activity.
AID153664Inhibitory activity against growth of P388 leukemia cells was determined1998Bioorganic & medicinal chemistry letters, Aug-18, Volume: 8, Issue:16
Antineoplastic agents. 397: Isolation and structure of sesterstatins 4 and 5 from Hyrtios erecta (the Republic of Maldives).
AID403378Growth inhibition of human DU145 cells2005Journal of natural products, Aug, Volume: 68, Issue:8
Antineoplastic agents. 542. Isolation and structure of sesterstatin 6 from the Indian Ocean sponge Hyrtios erecta.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (20.00)18.2507
2000's2 (40.00)29.6817
2010's2 (40.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.87

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.87 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.66 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.87)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (20.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other4 (80.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
ciprofloxacin
Ciprofloxacin: A broad-spectrum antimicrobial carboxyfluoroquinoline.. ciprofloxacin : A quinolone that is quinolin-4(1H)-one bearing cyclopropyl, carboxylic acid, fluoro and piperazin-1-yl substituents at positions 1, 3, 6 and 7, respectively.		2.0510aminoquinoline;
cyclopropanes;
fluoroquinolone antibiotic;
N-arylpiperazine;
quinolinemonocarboxylic acid;
quinolone antibiotic;
quinolone;
zwitterion		antibacterial drug;
antiinfective agent;
antimicrobial agent;
DNA synthesis inhibitor;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
environmental contaminant;
topoisomerase IV inhibitor;
xenobiotic
12-epi-scalarin
12-epi-scalarin : The 12-epimer of scalarin, a metabolite of marine sponges of the genus Spongia.		2.0510scalarane sesterterpenoidanimal metabolite
dibromophakellin
dibromophakellin: an alpha2B receptor agonist; isolated from Acanthella costata and Pseudoaxinyssa cantharella; structure in first source. (-)-dibromophakellin : An alkaloid isolated from the marine sponge Phakellia flabellata and Acanthella costata. It acts as an alpha2B adrenoceptor agonist.		3.2710alkaloid;
guanidines;
organobromine compound		alpha-adrenergic agonist;
animal metabolite;
marine metabolite
ConditionIndicatedRelationship StrengthStudiesTrials
Leukemia P388
An experimental lymphocytic leukemia originally induced in DBA/2 mice by painting with methylcholanthrene.		02.4120
Benign Neoplasms, Brain
[description not available]		03.0910
Central Nervous System Neoplasm
[description not available]		03.0910
Brain Neoplasms
Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.		03.0910
Central Nervous System Neoplasms
Benign and malignant neoplastic processes that arise from or secondarily involve the brain, spinal cord, or meninges.		03.0910
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