Page last updated: 2024-11-12

quinidine-n-oxide

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

quinidine-N-oxide: major metabolite of quinidine; RN given refers to (9S)-isomer [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID23622544
MeSH IDM0131353

Synonyms (6)

Synonym
quinidine-n-oxide
unii-t0rv6t22hz
cinchonan-9-ol, 6'-methoxy-, 1-oxide, (9s)-
t0rv6t22hz ,
Q27289518
(s)-[(1r,2r,4s,5r)-5-ethenyl-1-oxido-1-azoniabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol

Research Excerpts

Pharmacokinetics

ExcerptReferenceRelevance
" To investigate the pharmacodynamic interaction of the two compounds the concentration-response curve was determined for quinidine also in the presence of 3-hydroxyquinidine at a constant concentration of 4 mg/l."( Antiarrhythmic activity of two quinidine metabolites in experimental reperfusion arrhythmia: relative potency and pharmacodynamic interaction with the parent drug.
Follath, F; Oti-Amoako, K; Uematsu, T; Vozeh, S, 1987
)
0.27
" Plasma and urine samples were analysed for pharmacokinetic comparison of the drug and its metabolite."( Pharmacokinetics and pharmacodynamics of quinidine and its metabolite, quinidine-N-oxide, in beagle dogs.
Guentert, TW; Holford, NH; Rakhit, A; Riegelman, S; Verhoeven, J,
)
0.13

Dosage Studied

ExcerptRelevanceReference
" These results suggest that cigarette smoke does not induce any of the main pathways for quinidine metabolism in a typical patient population and that the consideration of smoking status is of little utility in aiding in the selection of initial dosage regimens for this drug."( Lack of effect of smoking on the metabolism and pharmacokinetics of quinidine in patients.
Axelson, JE; Edwards, DJ; Lalka, D; Slaughter, RL; vanEvery, S; Visco, JP, 1987
)
0.27
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

TimeframeStudies, This Drug (%)All Drugs %
pre-19904 (57.14)18.7374
1990's3 (42.86)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other9 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]