quinidine-N-oxide: major metabolite of quinidine; RN given refers to (9S)-isomer [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
ID Source | ID |
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PubMed CID | 23622544 |
MeSH ID | M0131353 |
Synonym |
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quinidine-n-oxide |
unii-t0rv6t22hz |
cinchonan-9-ol, 6'-methoxy-, 1-oxide, (9s)- |
t0rv6t22hz , |
Q27289518 |
(s)-[(1r,2r,4s,5r)-5-ethenyl-1-oxido-1-azoniabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol |
Excerpt | Reference | Relevance |
---|---|---|
" To investigate the pharmacodynamic interaction of the two compounds the concentration-response curve was determined for quinidine also in the presence of 3-hydroxyquinidine at a constant concentration of 4 mg/l." | ( Antiarrhythmic activity of two quinidine metabolites in experimental reperfusion arrhythmia: relative potency and pharmacodynamic interaction with the parent drug. Follath, F; Oti-Amoako, K; Uematsu, T; Vozeh, S, 1987) | 0.27 |
" Plasma and urine samples were analysed for pharmacokinetic comparison of the drug and its metabolite." | ( Pharmacokinetics and pharmacodynamics of quinidine and its metabolite, quinidine-N-oxide, in beagle dogs. Guentert, TW; Holford, NH; Rakhit, A; Riegelman, S; Verhoeven, J, ) | 0.13 |
Excerpt | Relevance | Reference |
---|---|---|
" These results suggest that cigarette smoke does not induce any of the main pathways for quinidine metabolism in a typical patient population and that the consideration of smoking status is of little utility in aiding in the selection of initial dosage regimens for this drug." | ( Lack of effect of smoking on the metabolism and pharmacokinetics of quinidine in patients. Axelson, JE; Edwards, DJ; Lalka, D; Slaughter, RL; vanEvery, S; Visco, JP, 1987) | 0.27 |
Timeframe | Studies, This Drug (%) | All Drugs % |
---|---|---|
pre-1990 | 4 (57.14) | 18.7374 |
1990's | 3 (42.86) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Publication Type | This drug (%) | All Drugs (%) |
---|---|---|
Trials | 0 (0.00%) | 5.53% |
Reviews | 0 (0.00%) | 6.00% |
Case Studies | 0 (0.00%) | 4.05% |
Observational | 0 (0.00%) | 0.25% |
Other | 9 (100.00%) | 84.16% |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |