Compounds > pentachlorothiophenol
Page last updated: 2024-12-05

pentachlorothiophenol

Pentachlorothiophenol is a sulfur-containing organic compound with the formula C6Cl5SH. It is a white to yellowish solid. Pentachlorothiophenol is a useful building block in organic synthesis. For example, it can be used to prepare thioethers, sulfides, and disulfides. It can also be used to synthesize other sulfur-containing heterocycles. Pentachlorothiophenol is a potent inhibitor of the enzyme glutathione S-transferase. Glutathione S-transferase is an enzyme that plays an important role in detoxification. Pentachlorothiophenol is also a known fungicide. This compound has been used to study the reaction mechanisms of certain organic reactions.'

Cross-References

ID SourceID
PubMed CID8620
SCHEMBL ID48512
MeSH IDM0062445

Synonyms (48)

Synonym
wln: shr bg cg dg eg fg
133-49-3
pentachlorothiophenol
pentachlorobenzenethiol
nsc-5578
pentachlorthiofenol
nsc5578
benzenethiol, pentachloro-
usaf b-51
rpa 6
2,3,4,5,6-pentachlorobenzenethiol
pentachloro-benzenethiol
nsc 5578
einecs 205-107-8
pctp
ai3-23118
hsdb 6124
pentachlorthiofenol [czech]
brn 1108638
AC-11106
P0312
A806624
AKOS005463160
2,3,4,5,6-pentachloro-benzenethiol
pentachloro thiophenol
STK530289
92a1z48vjb ,
4-06-00-01642 (beilstein handbook reference)
unii-92a1z48vjb
benzenethiol, 2,3,4,5,6-pentachloro-
FT-0631773
SCHEMBL48512
BBL028077
pentachlorothiophenol [hsdb]
DTXSID3044540
Q-201540
renacit 7 (salt/mix)
akrochem peptizer ptp
pentachloro benzenethiol
pentachlorthiophenol
2,3,4,5,6-pentachlorobenzenethiol #
mfcd00059146
pentachlorothiophenol, analytical standard
CS-0204835
pentachlorobenzene-1-thiol
VS-08658
Q1754155
D91942

Research Excerpts

Dosage Studied

ExcerptRelevanceReference
" The liver HCB concentration at 24 hr after dosing was higher in male rats than in female rats but decreased faster thereafter."( Sex-related difference in hepatic glutathione conjugation of hexachlorobenzene in the rat.
Charbonneau, M; D'Amour, M, 1992)		0.28
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

TimeframeStudies, This Drug (%)All Drugs %
pre-19902 (28.57)18.7374
1990's4 (57.14)18.2507
2000's1 (14.29)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 33.04

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index33.04 (24.57)
Research Supply Index2.08 (2.92)
Research Growth Index4.40 (4.65)
Search Engine Demand Index36.91 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (33.04)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other7 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
acetic acid
Acetic Acid: Product of the oxidation of ethanol and of the destructive distillation of wood. It is used locally, occasionally internally, as a counterirritant and also as a reagent. (Stedman, 26th ed). acetic acid : A simple monocarboxylic acid containing two carbons.		7.0210monocarboxylic acidantimicrobial food preservative;
Daphnia magna metabolite;
food acidity regulator;
protic solvent
pentachlorophenol
PENTA: structure given in first source		2.3620aromatic fungicide;
chlorophenol;
organochlorine pesticide;
pentachlorobenzenes		human xenobiotic metabolite
quintozene
quintozene: active ingredient of variety of fungicides. pentachloronitrobenzene : A C-nitro compound that is nitrobenzene in which every hydrogen has been replaced by a chlorine. A fungicide used on a variety of crops, including cotton, rice and seed grains, it is no longer approved for use within the European Union.		1.9710aromatic fungicide;
C-nitro compound;
pentachlorobenzenes		antifungal agrochemical
hexachlorobenzene
Hexachlorobenzene: An agricultural fungicide and seed treatment agent.. hexachlorobenzene : A member of the class of chlorobenzenes that is benzene in which all of the hydrogens are replaced by chlorines. An agricultural fungicide introduced in the mid-1940s and formerly used as a seed treatment, its use has been banned since 1984 under the Stockholm Convention on Persistent Organic Pollutants.		3.0750aromatic fungicide;
chlorobenzenes		antifungal agrochemical;
carcinogenic agent;
persistent organic pollutant
sulfur
Sulfur: An element that is a member of the chalcogen family. It has an atomic symbol S, atomic number 16, and atomic weight [32.059; 32.076]. It is found in the amino acids cysteine and methionine.		1.9710chalcogen;
nonmetal atom		macronutrient
phosphatidylcholines
Phosphatidylcholines: Derivatives of PHOSPHATIDIC ACIDS in which the phosphoric acid is bound in ester linkage to a CHOLINE moiety.		1.96101,2-diacyl-sn-glycero-3-phosphocholine
ConditionIndicatedRelationship StrengthStudiesTrials
Sensitivity and Specificity
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)		02.0210
Porphyria
[description not available]		01.9910
Porphyrias
A diverse group of metabolic diseases characterized by errors in the biosynthetic pathway of HEME in the LIVER, the BONE MARROW, or both. They are classified by the deficiency of specific enzymes, the tissue site of enzyme defect, or the clinical features that include neurological (acute) or cutaneous (skin lesions). Porphyrias can be hereditary or acquired as a result of toxicity to the hepatic or erythropoietic marrow tissues.		01.9910
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