Compounds > ophiobolin o
Page last updated: 2024-11-13

ophiobolin o

Description

ophiobolin O: from the marine derived fungus Aspergillus sp.; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID56835176
CHEMBL ID1934283
MeSH IDM0581259

Synonyms (2)

Synonym
CHEMBL1934283
ophiobolin o

Research Excerpts

Overview

Ophiobolin O is a natural compound that has been isolated from Aspergillus ustus 094102.

ExcerptReferenceRelevance
"Ophiobolin O is a natural compound that has been isolated from Aspergillus ustus 094102. "( The novel agent ophiobolin O induces apoptosis and cell cycle arrest of MCF-7 cells through activation of MAPK signaling pathways.
Hong, K; Huang, C; Lu, Z; Meng, L; Wei, S; Yang, T; Zhu, W, 2012)		2.17
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (42)

Assay IDTitleYearJournalArticle
AID638686Induction of apoptosis in human MCF7 cells assessed as decrease in Bcl2 expression level at 17.86 uM after 12 to 48 hrs by Western blot analysis2012Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1
The novel agent ophiobolin O induces apoptosis and cell cycle arrest of MCF-7 cells through activation of MAPK signaling pathways.
AID638674Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay2012Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1
The novel agent ophiobolin O induces apoptosis and cell cycle arrest of MCF-7 cells through activation of MAPK signaling pathways.
AID1505074Cytotoxicity against human MCF7/ADR cells after 72 hrs by MTT assay2018Journal of natural products, 01-26, Volume: 81, Issue:1
Ophiobolins from the Mangrove Fungus Aspergillus ustus.
AID638676Cell cycle arrest in human MCF7 cells assessed as accumulation at G0/G1 phase at 17.86 uM after 12 hrs by flow cytometry (Rvb = 39.34 +/- 3.37%)2012Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1
The novel agent ophiobolin O induces apoptosis and cell cycle arrest of MCF-7 cells through activation of MAPK signaling pathways.
AID638832Activation of MAPK p38 phosphorylation in human MCF7 cells at 17.86 uM after 48 hrs by Western blot analysis in presence of p38 inhibitor SB2035802012Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1
The novel agent ophiobolin O induces apoptosis and cell cycle arrest of MCF-7 cells through activation of MAPK signaling pathways.
AID638687Induction of apoptosis in human MCF7 cells assessed as increase in Bim expression level at 17.86 uM after 12 to 48 hrs by Western blot analysis2012Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1
The novel agent ophiobolin O induces apoptosis and cell cycle arrest of MCF-7 cells through activation of MAPK signaling pathways.
AID1505077Cytotoxicity against human MCF10A cells after 72 hrs by MTT assay2018Journal of natural products, 01-26, Volume: 81, Issue:1
Ophiobolins from the Mangrove Fungus Aspergillus ustus.
AID1849912Antitumor activity against Adriamycin-resistant human MCF7 cells xenografted in athymic nude BALB/c mouse assessed as tumor growth inhibition at 5 mg/kg, iv measured every 4 days for 40 days by caliper method in presence of Adriamycin relative to control2021European journal of medicinal chemistry, Jan-15, Volume: 210Chemistry, biosynthesis and biological activity of terpenoids and meroterpenoids in bacteria and fungi isolated from different marine habitats.
AID1505067Antimicrobial activity against Pseudomonas aeruginosa ATCC 10145 at 1 ug after 24 hrs by paper disc agar diffusion method2018Journal of natural products, 01-26, Volume: 81, Issue:1
Ophiobolins from the Mangrove Fungus Aspergillus ustus.
AID1505068Antimicrobial activity against Escherichia coli ATCC 11775 at 1 ug after 24 hrs by paper disc agar diffusion method2018Journal of natural products, 01-26, Volume: 81, Issue:1
Ophiobolins from the Mangrove Fungus Aspergillus ustus.
AID1505071Cytotoxicity against human G3K cells after 72 hrs by MTT assay2018Journal of natural products, 01-26, Volume: 81, Issue:1
Ophiobolins from the Mangrove Fungus Aspergillus ustus.
AID638680Induction of apoptosis in human MCF7 cells at 17.86 uM using Annexin V-FITC and propidium iodide staining by flow cytometry2012Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1
The novel agent ophiobolin O induces apoptosis and cell cycle arrest of MCF-7 cells through activation of MAPK signaling pathways.
AID638829Induction of apoptosis in human MCF7 cells assessed as change in Bax/Bcl2 ratio at 17.86 uM by Western blot analysis2012Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1
The novel agent ophiobolin O induces apoptosis and cell cycle arrest of MCF-7 cells through activation of MAPK signaling pathways.
AID638834Induction of apoptosis in human MCF7 cells assessed as change in Bcl-2 protein level at 17.86 uM after 12 hrs by Western blot analysis in presence of JNK inhibitor SP6001252012Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1
The novel agent ophiobolin O induces apoptosis and cell cycle arrest of MCF-7 cells through activation of MAPK signaling pathways.
AID1505072Cytotoxicity against human MDA-MB-231 cells after 72 hrs by MTT assay2018Journal of natural products, 01-26, Volume: 81, Issue:1
Ophiobolins from the Mangrove Fungus Aspergillus ustus.
AID638837Effect on total JNK protein level in human MCF7 cells at 17.86 uM after 12 to 48 hrs by Western blot analysis2012Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1
The novel agent ophiobolin O induces apoptosis and cell cycle arrest of MCF-7 cells through activation of MAPK signaling pathways.
AID1849910Antitumor activity against human MCF7 cells xenografted in athymic nude BALB/c mouse assessed as tumor growth inhibition at 20 mg/kg, iv measured every 4 days for 40 days by caliper method relative to PTX2021European journal of medicinal chemistry, Jan-15, Volume: 210Chemistry, biosynthesis and biological activity of terpenoids and meroterpenoids in bacteria and fungi isolated from different marine habitats.
AID638836Effect on total MAPK p38 protein level in human MCF7 cells at 17.86 uM after 12 to 48 hrs by Western blot analysis2012Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1
The novel agent ophiobolin O induces apoptosis and cell cycle arrest of MCF-7 cells through activation of MAPK signaling pathways.
AID638830Induction of apoptosis in human MCF7 cells at 17.86 uM after 48 hrs by using Annexin V-FITC and propidium iodide staining by flow cytometry in presence of JNK inhibitor SP6001252012Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1
The novel agent ophiobolin O induces apoptosis and cell cycle arrest of MCF-7 cells through activation of MAPK signaling pathways.
AID638675Cytotoxicity against human HUVEC cells after 48 hrs by MTT assay2012Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1
The novel agent ophiobolin O induces apoptosis and cell cycle arrest of MCF-7 cells through activation of MAPK signaling pathways.
AID638831Activation of ERK1/2 phosphorylation in human MCF7 cells at 17.86 uM after 48 hrs by Western blot analysis in presence of ERK inhibitor U01262012Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1
The novel agent ophiobolin O induces apoptosis and cell cycle arrest of MCF-7 cells through activation of MAPK signaling pathways.
AID638677Cell cycle arrest in human MCF7 cells assessed as accumulation at G0/G1 phase at 17.86 uM after 24 hrs by flow cytometry (Rvb = 39.34 +/- 3.37%)2012Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1
The novel agent ophiobolin O induces apoptosis and cell cycle arrest of MCF-7 cells through activation of MAPK signaling pathways.
AID638684Activation of MAPK p38 phosphorylation in human MCF7 cells at 17.86 uM after 12 hrs by Western blot analysis2012Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1
The novel agent ophiobolin O induces apoptosis and cell cycle arrest of MCF-7 cells through activation of MAPK signaling pathways.
AID1505066Antimicrobial activity against Candida albicans ATCC 10231 at 1 ug after 24 hrs by paper disc agar diffusion method2018Journal of natural products, 01-26, Volume: 81, Issue:1
Ophiobolins from the Mangrove Fungus Aspergillus ustus.
AID1505076Cytotoxicity against human HL60 cells after 72 hrs by MTT assay2018Journal of natural products, 01-26, Volume: 81, Issue:1
Ophiobolins from the Mangrove Fungus Aspergillus ustus.
AID1849908Antitumor activity against human MCF7 cells xenografted in athymic nude BALB/c mouse assessed as tumor growth inhibition at 10 mg/kg, iv measured every 4 days for 40 days by caliper method relative to control2021European journal of medicinal chemistry, Jan-15, Volume: 210Chemistry, biosynthesis and biological activity of terpenoids and meroterpenoids in bacteria and fungi isolated from different marine habitats.
AID638678Cell cycle arrest in human MCF7 cells assessed as accumulation at G0/G1 phase at 17.86 uM after 48 hrs by flow cytometry (Rvb = 39.34 +/- 3.37%)2012Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1
The novel agent ophiobolin O induces apoptosis and cell cycle arrest of MCF-7 cells through activation of MAPK signaling pathways.
AID638828Induction of apoptosis in human MCF7 cells assessed as change in Bax expression level at 17.86 uM after 12 to 48 hrs by Western blot analysis2012Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1
The novel agent ophiobolin O induces apoptosis and cell cycle arrest of MCF-7 cells through activation of MAPK signaling pathways.
AID1505070Antimicrobial activity against Bacillus subtilis ATCC 6051 at 1 ug after 24 hrs by paper disc agar diffusion method2018Journal of natural products, 01-26, Volume: 81, Issue:1
Ophiobolins from the Mangrove Fungus Aspergillus ustus.
AID638682Activation of ERK1/2 phosphorylation in human MCF7 cells at 17.86 uM after 24 hrs by Western blot analysis relative to control2012Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1
The novel agent ophiobolin O induces apoptosis and cell cycle arrest of MCF-7 cells through activation of MAPK signaling pathways.
AID638835Effect on total ERK 1/2 protein level in human MCF7 cells at 17.86 uM after 12 to 48 hrs by Western blot analysis2012Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1
The novel agent ophiobolin O induces apoptosis and cell cycle arrest of MCF-7 cells through activation of MAPK signaling pathways.
AID638683Activation of JNK phosphorylation in human MCF7 cells at 17.86 uM after 24 hrs by Western blot analysis2012Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1
The novel agent ophiobolin O induces apoptosis and cell cycle arrest of MCF-7 cells through activation of MAPK signaling pathways.
AID1505073Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay2018Journal of natural products, 01-26, Volume: 81, Issue:1
Ophiobolins from the Mangrove Fungus Aspergillus ustus.
AID638681Induction of apoptosis in human MCF7 cells at 17.86 uM after 48 hrs using Annexin V-FITC and propidium iodide staining by flow cytometry (Rvb = 3.71 +/- 0.63%)2012Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1
The novel agent ophiobolin O induces apoptosis and cell cycle arrest of MCF-7 cells through activation of MAPK signaling pathways.
AID1505075Cytotoxicity against human A549 cells after 72 hrs by MTT assay2018Journal of natural products, 01-26, Volume: 81, Issue:1
Ophiobolins from the Mangrove Fungus Aspergillus ustus.
AID1849907Antitumor activity against human MCF7 cells xenografted in athymic nude BALB/c mouse assessed as tumor growth inhibition at 5 mg/kg, iv measured every 4 days for 40 days by caliper method relative to control2021European journal of medicinal chemistry, Jan-15, Volume: 210Chemistry, biosynthesis and biological activity of terpenoids and meroterpenoids in bacteria and fungi isolated from different marine habitats.
AID638685Activation of MAPK p38 phosphorylation in human MCF7 cells at 17.86 uM after 36 to 48 hrs by Western blot analysis2012Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1
The novel agent ophiobolin O induces apoptosis and cell cycle arrest of MCF-7 cells through activation of MAPK signaling pathways.
AID638679Cell cycle arrest in human MCF7 cells assessed as accumulation at G0/G1 phase at 17.86 uM by flow cytometry2012Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1
The novel agent ophiobolin O induces apoptosis and cell cycle arrest of MCF-7 cells through activation of MAPK signaling pathways.
AID1505069Antimicrobial activity against Enterobacter aerogenes ATCC 13048 at 1 ug after 24 hrs by paper disc agar diffusion method2018Journal of natural products, 01-26, Volume: 81, Issue:1
Ophiobolins from the Mangrove Fungus Aspergillus ustus.
AID1849911Antitumor activity against Adriamycin-resistant human MCF7 cells xenografted in athymic nude BALB/c mouse assessed as tumor growth inhibition at 5 mg/kg, iv measured every 4 days for 40 days by caliper method relative to control2021European journal of medicinal chemistry, Jan-15, Volume: 210Chemistry, biosynthesis and biological activity of terpenoids and meroterpenoids in bacteria and fungi isolated from different marine habitats.
AID638833Induction of apoptosis in human MCF7 cells assessed as increase of Bcl-2 phosphorylation at Ser70 at 17.86 uM after 12 hrs by Western blot analysis in presence of JNK inhibitor SP6001252012Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1
The novel agent ophiobolin O induces apoptosis and cell cycle arrest of MCF-7 cells through activation of MAPK signaling pathways.
AID1849909Antitumor activity against human MCF7 cells xenografted in athymic nude BALB/c mouse assessed as tumor growth inhibition at 20 mg/kg, iv measured every 4 days for 40 days by caliper method relative to control2021European journal of medicinal chemistry, Jan-15, Volume: 210Chemistry, biosynthesis and biological activity of terpenoids and meroterpenoids in bacteria and fungi isolated from different marine habitats.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's4 (66.67)24.3611
2020's2 (33.33)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.72

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.72 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.66 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.72)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (16.67%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (83.33%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
indomethacin
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.. indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.		3.4110aromatic ether;
indole-3-acetic acids;
monochlorobenzenes;
N-acylindole		analgesic;
drug metabolite;
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
environmental contaminant;
gout suppressant;
non-steroidal anti-inflammatory drug;
xenobiotic metabolite;
xenobiotic
oseltamivir
Oseltamivir: An acetamido cyclohexene that is a structural homolog of SIALIC ACID and inhibits NEURAMINIDASE.. oseltamivir : A cyclohexenecarboxylate ester that is the ethyl ester of oseltamivir acid. An antiviral prodrug (it is hydrolysed to the active free carboxylic acid in the liver), it is used to slow the spread of influenza.		3.4110acetamides;
amino acid ester;
cyclohexenecarboxylate ester;
primary amino compound		antiviral drug;
EC 3.2.1.18 (exo-alpha-sialidase) inhibitor;
environmental contaminant;
prodrug;
xenobiotic
doxorubicin hydrochloride
[no description available]		3.7320anthracycline
hirsutanol a
hirsutanol A: from fungus chondrostereum sp.; structure in first source		3.4110
altemicidin
altemicidin: sulfamino given in first source; monoterpene alkaloid; isolated from Actinomycete		3.4110
ConditionIndicatedRelationship StrengthStudiesTrials
Breast Cancer
[description not available]		02.0710
Breast Neoplasms
Tumors or cancer of the human BREAST.		02.0710
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