| Assay ID | Title | Year | Journal | Article |
|---|
| AID638686 | Induction of apoptosis in human MCF7 cells assessed as decrease in Bcl2 expression level at 17.86 uM after 12 to 48 hrs by Western blot analysis | 2012 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1
| The novel agent ophiobolin O induces apoptosis and cell cycle arrest of MCF-7 cells through activation of MAPK signaling pathways. |
| AID638674 | Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay | 2012 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1
| The novel agent ophiobolin O induces apoptosis and cell cycle arrest of MCF-7 cells through activation of MAPK signaling pathways. |
| AID1505074 | Cytotoxicity against human MCF7/ADR cells after 72 hrs by MTT assay | 2018 | Journal of natural products, 01-26, Volume: 81, Issue:1
| Ophiobolins from the Mangrove Fungus Aspergillus ustus. |
| AID638676 | Cell cycle arrest in human MCF7 cells assessed as accumulation at G0/G1 phase at 17.86 uM after 12 hrs by flow cytometry (Rvb = 39.34 +/- 3.37%) | 2012 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1
| The novel agent ophiobolin O induces apoptosis and cell cycle arrest of MCF-7 cells through activation of MAPK signaling pathways. |
| AID638832 | Activation of MAPK p38 phosphorylation in human MCF7 cells at 17.86 uM after 48 hrs by Western blot analysis in presence of p38 inhibitor SB203580 | 2012 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1
| The novel agent ophiobolin O induces apoptosis and cell cycle arrest of MCF-7 cells through activation of MAPK signaling pathways. |
| AID638687 | Induction of apoptosis in human MCF7 cells assessed as increase in Bim expression level at 17.86 uM after 12 to 48 hrs by Western blot analysis | 2012 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1
| The novel agent ophiobolin O induces apoptosis and cell cycle arrest of MCF-7 cells through activation of MAPK signaling pathways. |
| AID1505077 | Cytotoxicity against human MCF10A cells after 72 hrs by MTT assay | 2018 | Journal of natural products, 01-26, Volume: 81, Issue:1
| Ophiobolins from the Mangrove Fungus Aspergillus ustus. |
| AID1849912 | Antitumor activity against Adriamycin-resistant human MCF7 cells xenografted in athymic nude BALB/c mouse assessed as tumor growth inhibition at 5 mg/kg, iv measured every 4 days for 40 days by caliper method in presence of Adriamycin relative to control | 2021 | European journal of medicinal chemistry, Jan-15, Volume: 210 | Chemistry, biosynthesis and biological activity of terpenoids and meroterpenoids in bacteria and fungi isolated from different marine habitats. |
| AID1505067 | Antimicrobial activity against Pseudomonas aeruginosa ATCC 10145 at 1 ug after 24 hrs by paper disc agar diffusion method | 2018 | Journal of natural products, 01-26, Volume: 81, Issue:1
| Ophiobolins from the Mangrove Fungus Aspergillus ustus. |
| AID1505068 | Antimicrobial activity against Escherichia coli ATCC 11775 at 1 ug after 24 hrs by paper disc agar diffusion method | 2018 | Journal of natural products, 01-26, Volume: 81, Issue:1
| Ophiobolins from the Mangrove Fungus Aspergillus ustus. |
| AID1505071 | Cytotoxicity against human G3K cells after 72 hrs by MTT assay | 2018 | Journal of natural products, 01-26, Volume: 81, Issue:1
| Ophiobolins from the Mangrove Fungus Aspergillus ustus. |
| AID638680 | Induction of apoptosis in human MCF7 cells at 17.86 uM using Annexin V-FITC and propidium iodide staining by flow cytometry | 2012 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1
| The novel agent ophiobolin O induces apoptosis and cell cycle arrest of MCF-7 cells through activation of MAPK signaling pathways. |
| AID638829 | Induction of apoptosis in human MCF7 cells assessed as change in Bax/Bcl2 ratio at 17.86 uM by Western blot analysis | 2012 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1
| The novel agent ophiobolin O induces apoptosis and cell cycle arrest of MCF-7 cells through activation of MAPK signaling pathways. |
| AID638834 | Induction of apoptosis in human MCF7 cells assessed as change in Bcl-2 protein level at 17.86 uM after 12 hrs by Western blot analysis in presence of JNK inhibitor SP600125 | 2012 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1
| The novel agent ophiobolin O induces apoptosis and cell cycle arrest of MCF-7 cells through activation of MAPK signaling pathways. |
| AID1505072 | Cytotoxicity against human MDA-MB-231 cells after 72 hrs by MTT assay | 2018 | Journal of natural products, 01-26, Volume: 81, Issue:1
| Ophiobolins from the Mangrove Fungus Aspergillus ustus. |
| AID638837 | Effect on total JNK protein level in human MCF7 cells at 17.86 uM after 12 to 48 hrs by Western blot analysis | 2012 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1
| The novel agent ophiobolin O induces apoptosis and cell cycle arrest of MCF-7 cells through activation of MAPK signaling pathways. |
| AID1849910 | Antitumor activity against human MCF7 cells xenografted in athymic nude BALB/c mouse assessed as tumor growth inhibition at 20 mg/kg, iv measured every 4 days for 40 days by caliper method relative to PTX | 2021 | European journal of medicinal chemistry, Jan-15, Volume: 210 | Chemistry, biosynthesis and biological activity of terpenoids and meroterpenoids in bacteria and fungi isolated from different marine habitats. |
| AID638836 | Effect on total MAPK p38 protein level in human MCF7 cells at 17.86 uM after 12 to 48 hrs by Western blot analysis | 2012 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1
| The novel agent ophiobolin O induces apoptosis and cell cycle arrest of MCF-7 cells through activation of MAPK signaling pathways. |
| AID638830 | Induction of apoptosis in human MCF7 cells at 17.86 uM after 48 hrs by using Annexin V-FITC and propidium iodide staining by flow cytometry in presence of JNK inhibitor SP600125 | 2012 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1
| The novel agent ophiobolin O induces apoptosis and cell cycle arrest of MCF-7 cells through activation of MAPK signaling pathways. |
| AID638675 | Cytotoxicity against human HUVEC cells after 48 hrs by MTT assay | 2012 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1
| The novel agent ophiobolin O induces apoptosis and cell cycle arrest of MCF-7 cells through activation of MAPK signaling pathways. |
| AID638831 | Activation of ERK1/2 phosphorylation in human MCF7 cells at 17.86 uM after 48 hrs by Western blot analysis in presence of ERK inhibitor U0126 | 2012 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1
| The novel agent ophiobolin O induces apoptosis and cell cycle arrest of MCF-7 cells through activation of MAPK signaling pathways. |
| AID638677 | Cell cycle arrest in human MCF7 cells assessed as accumulation at G0/G1 phase at 17.86 uM after 24 hrs by flow cytometry (Rvb = 39.34 +/- 3.37%) | 2012 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1
| The novel agent ophiobolin O induces apoptosis and cell cycle arrest of MCF-7 cells through activation of MAPK signaling pathways. |
| AID638684 | Activation of MAPK p38 phosphorylation in human MCF7 cells at 17.86 uM after 12 hrs by Western blot analysis | 2012 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1
| The novel agent ophiobolin O induces apoptosis and cell cycle arrest of MCF-7 cells through activation of MAPK signaling pathways. |
| AID1505066 | Antimicrobial activity against Candida albicans ATCC 10231 at 1 ug after 24 hrs by paper disc agar diffusion method | 2018 | Journal of natural products, 01-26, Volume: 81, Issue:1
| Ophiobolins from the Mangrove Fungus Aspergillus ustus. |
| AID1505076 | Cytotoxicity against human HL60 cells after 72 hrs by MTT assay | 2018 | Journal of natural products, 01-26, Volume: 81, Issue:1
| Ophiobolins from the Mangrove Fungus Aspergillus ustus. |
| AID1849908 | Antitumor activity against human MCF7 cells xenografted in athymic nude BALB/c mouse assessed as tumor growth inhibition at 10 mg/kg, iv measured every 4 days for 40 days by caliper method relative to control | 2021 | European journal of medicinal chemistry, Jan-15, Volume: 210 | Chemistry, biosynthesis and biological activity of terpenoids and meroterpenoids in bacteria and fungi isolated from different marine habitats. |
| AID638678 | Cell cycle arrest in human MCF7 cells assessed as accumulation at G0/G1 phase at 17.86 uM after 48 hrs by flow cytometry (Rvb = 39.34 +/- 3.37%) | 2012 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1
| The novel agent ophiobolin O induces apoptosis and cell cycle arrest of MCF-7 cells through activation of MAPK signaling pathways. |
| AID638828 | Induction of apoptosis in human MCF7 cells assessed as change in Bax expression level at 17.86 uM after 12 to 48 hrs by Western blot analysis | 2012 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1
| The novel agent ophiobolin O induces apoptosis and cell cycle arrest of MCF-7 cells through activation of MAPK signaling pathways. |
| AID1505070 | Antimicrobial activity against Bacillus subtilis ATCC 6051 at 1 ug after 24 hrs by paper disc agar diffusion method | 2018 | Journal of natural products, 01-26, Volume: 81, Issue:1
| Ophiobolins from the Mangrove Fungus Aspergillus ustus. |
| AID638682 | Activation of ERK1/2 phosphorylation in human MCF7 cells at 17.86 uM after 24 hrs by Western blot analysis relative to control | 2012 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1
| The novel agent ophiobolin O induces apoptosis and cell cycle arrest of MCF-7 cells through activation of MAPK signaling pathways. |
| AID638835 | Effect on total ERK 1/2 protein level in human MCF7 cells at 17.86 uM after 12 to 48 hrs by Western blot analysis | 2012 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1
| The novel agent ophiobolin O induces apoptosis and cell cycle arrest of MCF-7 cells through activation of MAPK signaling pathways. |
| AID638683 | Activation of JNK phosphorylation in human MCF7 cells at 17.86 uM after 24 hrs by Western blot analysis | 2012 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1
| The novel agent ophiobolin O induces apoptosis and cell cycle arrest of MCF-7 cells through activation of MAPK signaling pathways. |
| AID1505073 | Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay | 2018 | Journal of natural products, 01-26, Volume: 81, Issue:1
| Ophiobolins from the Mangrove Fungus Aspergillus ustus. |
| AID638681 | Induction of apoptosis in human MCF7 cells at 17.86 uM after 48 hrs using Annexin V-FITC and propidium iodide staining by flow cytometry (Rvb = 3.71 +/- 0.63%) | 2012 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1
| The novel agent ophiobolin O induces apoptosis and cell cycle arrest of MCF-7 cells through activation of MAPK signaling pathways. |
| AID1505075 | Cytotoxicity against human A549 cells after 72 hrs by MTT assay | 2018 | Journal of natural products, 01-26, Volume: 81, Issue:1
| Ophiobolins from the Mangrove Fungus Aspergillus ustus. |
| AID1849907 | Antitumor activity against human MCF7 cells xenografted in athymic nude BALB/c mouse assessed as tumor growth inhibition at 5 mg/kg, iv measured every 4 days for 40 days by caliper method relative to control | 2021 | European journal of medicinal chemistry, Jan-15, Volume: 210 | Chemistry, biosynthesis and biological activity of terpenoids and meroterpenoids in bacteria and fungi isolated from different marine habitats. |
| AID638685 | Activation of MAPK p38 phosphorylation in human MCF7 cells at 17.86 uM after 36 to 48 hrs by Western blot analysis | 2012 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1
| The novel agent ophiobolin O induces apoptosis and cell cycle arrest of MCF-7 cells through activation of MAPK signaling pathways. |
| AID638679 | Cell cycle arrest in human MCF7 cells assessed as accumulation at G0/G1 phase at 17.86 uM by flow cytometry | 2012 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1
| The novel agent ophiobolin O induces apoptosis and cell cycle arrest of MCF-7 cells through activation of MAPK signaling pathways. |
| AID1505069 | Antimicrobial activity against Enterobacter aerogenes ATCC 13048 at 1 ug after 24 hrs by paper disc agar diffusion method | 2018 | Journal of natural products, 01-26, Volume: 81, Issue:1
| Ophiobolins from the Mangrove Fungus Aspergillus ustus. |
| AID1849911 | Antitumor activity against Adriamycin-resistant human MCF7 cells xenografted in athymic nude BALB/c mouse assessed as tumor growth inhibition at 5 mg/kg, iv measured every 4 days for 40 days by caliper method relative to control | 2021 | European journal of medicinal chemistry, Jan-15, Volume: 210 | Chemistry, biosynthesis and biological activity of terpenoids and meroterpenoids in bacteria and fungi isolated from different marine habitats. |
| AID638833 | Induction of apoptosis in human MCF7 cells assessed as increase of Bcl-2 phosphorylation at Ser70 at 17.86 uM after 12 hrs by Western blot analysis in presence of JNK inhibitor SP600125 | 2012 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1
| The novel agent ophiobolin O induces apoptosis and cell cycle arrest of MCF-7 cells through activation of MAPK signaling pathways. |
| AID1849909 | Antitumor activity against human MCF7 cells xenografted in athymic nude BALB/c mouse assessed as tumor growth inhibition at 20 mg/kg, iv measured every 4 days for 40 days by caliper method relative to control | 2021 | European journal of medicinal chemistry, Jan-15, Volume: 210 | Chemistry, biosynthesis and biological activity of terpenoids and meroterpenoids in bacteria and fungi isolated from different marine habitats. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |