Page last updated: 2024-11-12

jiadifenin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

jiadifenin: seco-prezizaane-type sesquiterpene with neurotrophic activity from Illicium jiadifengpi; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Flora	Rank	Flora Definition	Family	Family Definition
Illicium	genus	A plant genus of the family SCHISANDRACEAE, order AUSTROBAILEYALES, class MAGNOLIOPSIDA. They have evergreen, aromatic leaves and bisexual flowers. The female portion of the flower consists of 7 to 15 carpels.[MeSH]	Schisandraceae	A plant family of the order AUSTROBAILEYALES, class MAGNOLIOPSIDA.[MeSH]

Cross-References

ID Source	ID
PubMed CID	11544617
CHEMBL ID	465570
MeSH ID	M0428849

Synonyms (3)

Synonym
jiadifenin
CHEMBL465570
methyl (1r,2r,6r,10r,11r)-10,13-dihydroxy-2,6-dimethyl-3,9-dioxo-8,12-dioxatetracyclo[9.2.1.01,5.06,10]tetradec-4-ene-13-carboxylate

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (1)

Assay ID	Title	Year	Journal	Article
AID334220	Neurotrophic activity in Sprague-Dawley rat neurons assessed as induction of neurite outgrowth at 0.1 to 10 uM after 5 days by microscopy	2002	Journal of natural products, Apr, Volume: 65, Issue:4	New seco-prezizaane-type sesquiterpenes, jiadifenin with neurotrophic activity and 1,2-dehydroneomajucin from Illicium jiadifengpi.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (10)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	4 (40.00)	29.6817
2010's	5 (50.00)	24.3611
2020's	1 (10.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.23

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	12.23 (24.57)
Research Supply Index	2.40 (2.92)
Research Growth Index	4.63 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (12.23)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	2 (20.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	8 (80.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
cyclopentane Cyclopentanes: A group of alicyclic hydrocarbons with the general formula R-C5H9.. cyclopentanes : Cyclopentane and its derivatives formed by substitution.	3.51	1	cycloalkane; cyclopentanes; volatile organic compound	non-polar solvent
palladium Palladium: A chemical element having an atomic weight of 106.4, atomic number of 46, and the symbol Pd. It is a white, ductile metal resembling platinum, and following it in abundance and importance of applications. It is used in dentistry in the form of gold, silver, and copper alloys.. palladium : Chemical element (nickel group element atom) with atomic number 46.	7.45	2	metal allergen; nickel group element atom; platinum group metal atom
limonin [no description available]	3.27	1	epoxide; furans; hexacyclic triterpenoid; lactone; limonoid; organic heterohexacyclic compound	inhibitor; metabolite; volatile oil component
sesquiterpenes [no description available]	10.37	10
garsubellin a garsubellin A: from wood of Garcinia subelliptica; structure given in first source	2.03	1
scabronine g scabronine G: stimulates secretion of neurotrophic factor; structure in first source	2.03	1
jiadifenolide jiadifenolide: from Illicium jiadifengpi; structure in first source	2.08	1
11-o-debenzoyltashironin 11-O-debenzoyltashironin: structure in first source	2.03	1
crotogoudin crotogoudin: has antineoplastic activity; structure in first source	3.27	1
merrilactone a merrilactone A: structure in first source	3.6	2

Condition	Indicated	Relationship Strength	Studies	Trials
Degenerative Diseases, Central Nervous System [description not available]	0	3.42	2	0
Neurodegenerative Diseases Hereditary and sporadic conditions which are characterized by progressive nervous system dysfunction. These disorders are often associated with atrophy of the affected central or peripheral nervous system structures.	0	3.42	2	0

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