Compounds > merrilactone a
Page last updated: 2024-10-15

merrilactone a

Description

merrilactone A: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID164512929
MeSH IDM0429253

Synonyms (7)

Synonym
merrilactone a
DTXSID101028870
(+)-merrilactone a
dzs2xp3qh2 ,
unii-dzs2xp3qh2
(2s,2as,5as,5bs,8as,8br,10s)-tetrahydro-10-hydroxy-2,5b,8a-trimethyl-2,5a-ethano-2h,5ah,8h-furo(3',4':4,5)oxeto(3',2':2,3)cyclopenta(1,2-b)furan-4,8(3h)-dione
301842-37-5

Effects

ExcerptReference
"Merrilactone A (1) has been shown to possess neurotrophic activity and thus is expected to hold therapeutic potential in the treatment of neurodegeneration diseases. "( Total synthesis of merrilactone A.
Hirama, M; Inoue, M; Sato, T, 2003)
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (16)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's10 (62.50)29.6817
2010's3 (18.75)24.3611
2020's3 (18.75)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (6.25%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other15 (93.75%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
cyanides
Cyanides: Inorganic salts of HYDROGEN CYANIDE containing the -CN radical. The concept also includes isocyanides. It is distinguished from NITRILES, which denotes organic compounds containing the -CN radical.. cyanides : Salts and C-organyl derivatives of hydrogen cyanide, HC#N.. isocyanide : The isomer HN(+)#C(-) of hydrocyanic acid, HC#N, and its hydrocarbyl derivatives RNC (RN(+)#C(-)).. cyanide : A pseudohalide anion that is the conjugate base of hydrogen cyanide.		2.0710pseudohalide anionEC 1.9.3.1 (cytochrome c oxidase) inhibitor
cyclopentane
Cyclopentanes: A group of alicyclic hydrocarbons with the general formula R-C5H9.. cyclopentanes : Cyclopentane and its derivatives formed by substitution.		3.5110cycloalkane;
cyclopentanes;
volatile organic compound		non-polar solvent
palladium
Palladium: A chemical element having an atomic weight of 106.4, atomic number of 46, and the symbol Pd. It is a white, ductile metal resembling platinum, and following it in abundance and importance of applications. It is used in dentistry in the form of gold, silver, and copper alloys.. palladium : Chemical element (nickel group element atom) with atomic number 46.		2.0210metal allergen;
nickel group element atom;
platinum group metal atom
alkenes
[no description available]		2.0710
sesquiterpenes
[no description available]		5.29160
silicon
Silicon: A trace element that constitutes about 27.6% of the earth's crust in the form of SILICON DIOXIDE. It does not occur free in nature. Silicon has the atomic symbol Si, atomic number 14, and atomic weight [28.084; 28.086].		2.0410carbon group element atom;
metalloid atom;
nonmetal atom
garsubellin a
garsubellin A: from wood of Garcinia subelliptica; structure given in first source		2.0310
scabronine g
scabronine G: stimulates secretion of neurotrophic factor; structure in first source		2.0310
jiadifenin
jiadifenin: seco-prezizaane-type sesquiterpene with neurotrophic activity from Illicium jiadifengpi; structure in first source		3.620
11-o-debenzoyltashironin
11-O-debenzoyltashironin: structure in first source		2.0310
ConditionIndicatedRelationship StrengthStudiesTrials
Degenerative Diseases, Central Nervous System
[description not available]		03.4220
Neurodegenerative Diseases
Hereditary and sporadic conditions which are characterized by progressive nervous system dysfunction. These disorders are often associated with atrophy of the affected central or peripheral nervous system structures.		03.4220