merrilactone a

Description

merrilactone A: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	164512929
MeSH ID	M0429253

Synonyms (7)

Synonym
merrilactone a
DTXSID101028870
(+)-merrilactone a
dzs2xp3qh2 ,
unii-dzs2xp3qh2
(2s,2as,5as,5bs,8as,8br,10s)-tetrahydro-10-hydroxy-2,5b,8a-trimethyl-2,5a-ethano-2h,5ah,8h-furo(3',4':4,5)oxeto(3',2':2,3)cyclopenta(1,2-b)furan-4,8(3h)-dione
301842-37-5

Effects

Excerpt	Reference
"Merrilactone A (1) has been shown to possess neurotrophic activity and thus is expected to hold therapeutic potential in the treatment of neurodegeneration diseases. "	( Total synthesis of merrilactone A. Hirama, M; Inoue, M; Sato, T, 2003)

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (16)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	10 (62.50)	29.6817
2010's	3 (18.75)	24.3611
2020's	3 (18.75)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	1 (6.25%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	15 (93.75%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
cyanides Cyanides: Inorganic salts of HYDROGEN CYANIDE containing the -CN radical. The concept also includes isocyanides. It is distinguished from NITRILES, which denotes organic compounds containing the -CN radical.. cyanides : Salts and C-organyl derivatives of hydrogen cyanide, HC#N.. isocyanide : The isomer HN(+)#C(-) of hydrocyanic acid, HC#N, and its hydrocarbyl derivatives RNC (RN(+)#C(-)).. cyanide : A pseudohalide anion that is the conjugate base of hydrogen cyanide.	2.07	1	pseudohalide anion	EC 1.9.3.1 (cytochrome c oxidase) inhibitor
cyclopentane Cyclopentanes: A group of alicyclic hydrocarbons with the general formula R-C5H9.. cyclopentanes : Cyclopentane and its derivatives formed by substitution.	3.51	1	cycloalkane; cyclopentanes; volatile organic compound	non-polar solvent
palladium Palladium: A chemical element having an atomic weight of 106.4, atomic number of 46, and the symbol Pd. It is a white, ductile metal resembling platinum, and following it in abundance and importance of applications. It is used in dentistry in the form of gold, silver, and copper alloys.. palladium : Chemical element (nickel group element atom) with atomic number 46.	2.02	1	metal allergen; nickel group element atom; platinum group metal atom
alkenes [no description available]	2.07	1
sesquiterpenes [no description available]	5.29	16
silicon Silicon: A trace element that constitutes about 27.6% of the earth's crust in the form of SILICON DIOXIDE. It does not occur free in nature. Silicon has the atomic symbol Si, atomic number 14, and atomic weight [28.084; 28.086].	2.04	1	carbon group element atom; metalloid atom; nonmetal atom
garsubellin a garsubellin A: from wood of Garcinia subelliptica; structure given in first source	2.03	1
scabronine g scabronine G: stimulates secretion of neurotrophic factor; structure in first source	2.03	1
jiadifenin jiadifenin: seco-prezizaane-type sesquiterpene with neurotrophic activity from Illicium jiadifengpi; structure in first source	3.6	2
11-o-debenzoyltashironin 11-O-debenzoyltashironin: structure in first source	2.03	1

Condition	Indicated	Relationship Strength	Studies	Trials
Degenerative Diseases, Central Nervous System [description not available]	0	3.42	2	0
Neurodegenerative Diseases Hereditary and sporadic conditions which are characterized by progressive nervous system dysfunction. These disorders are often associated with atrophy of the affected central or peripheral nervous system structures.	0	3.42	2	0

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