fendosal

Description

Fendosal, also known as N-methyl-N-(2,6-dimethylphenyl)-2-(1H-indol-3-yl)acetamide, is a synthetic compound that has shown promising pharmacological activities. Its synthesis involves a multi-step process starting with indole and 2,6-dimethylaniline. Fendosal exhibits various effects, including anti-inflammatory, analgesic, and antipyretic properties. These effects are attributed to its ability to inhibit the enzyme cyclooxygenase (COX), which plays a role in the production of prostaglandins, inflammatory mediators. Its potential therapeutic applications in pain management and inflammation have led to extensive research efforts to understand its mechanisms of action and optimize its pharmacological profile. Researchers are particularly interested in its selectivity for COX-2, an isoform of COX that is primarily involved in inflammation, as this selectivity could potentially minimize the gastrointestinal side effects associated with non-selective COX inhibitors.'

fendosal: structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

fendosal : A benzoindole that is 4,5-dihydro-3H-benzo[e]indole in which the nitrogen is substituted by a 3-carboxy-4-hydroxyphenyl group. A non-narcotic analgesic and non-steroidal anti-inflammatory drug, it has greater analgesic and inflammatory responses than aspirin but with less gastrointestinal toxicity. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]