Compounds > dicranin
Page last updated: 2024-12-11

dicranin

Description

dicranin: from Dicranum scoparium; affects the metabolism of arachidonic acid in platelets & has effect on platelet aggregation [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

(9Z,12Z,15Z)-octadeca-9,12,15-trien-6-ynoic acid : A trienoic fatty acid, that is octadecanoic acid containing double bonds at positions 9, 12 and 15 and a triple bond at position 6. Isolated from Dicranum scoparium, it exhibits antibacterial activity and inhibitory activity against arachidonate 15-lipoxygenase. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

FloraRankFlora DefinitionFamilyFamily Definition
Dicranumgenus[no description available]Dicranaceae[no description available]
Dicranum scopariumspecies[no description available]Dicranaceae[no description available]

Cross-References

ID SourceID
PubMed CID44584408
CHEMBL ID458467
CHEBI ID65768
SCHEMBL ID9571641
MeSH IDM0203831

Synonyms (12)

Synonym
dicranin
chebi:65768 ,
CHEMBL458467
53766-42-0
(9z,12z,15z)-octadeca-9,12,15-trien-6-ynoic acid
SCHEMBL9571641
octadeca-6-yn-9,12,15(all z)-trienoic acid (18:4a)
LMFA01031109
9z,12z,15z-octadecatrien-6-ynoic acid
Q27134255
DTXSID701241222
(9z,12z,15z)-9,12,15-octadecatrien-6-ynoic acid
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (3)

RoleDescription
metaboliteAny intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.
antibacterial agentA substance (or active part thereof) that kills or slows the growth of bacteria.
EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitorA lipoxygenase inhibitor that interferes with the action of arachidonate 15-lipoxygenase (EC 1.13.11.33).
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (4)

ClassDescription
acetylenic fatty acidAny unsaturated fatty acid containing at least one triple bond in the carbon chain framework.
long-chain fatty acidA fatty acid with a chain length ranging from C13 to C22.
straight-chain fatty acidAny fatty acid whose skeletal carbon atoms form an unbranched open chain.
trienoic fatty acidAny polyunsaturated fatty acid that contains three double bonds.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (58)

Assay IDTitleYearJournalArticle
AID334526Antibacterial activity against Bacillus subtilis NCIB 3610 at 250 ug/disk after 24 hrs by disk diffusion assay1993Journal of natural products, Jul, Volume: 56, Issue:7
Dicranin, an antimicrobial and 15-lipoxygenase inhibitor from the moss Dicranum scoparium.
AID334530Antibacterial activity against Bacillus subtilis NCIB 3610 at 50 ug/disk after 24 hrs by disk diffusion assay1993Journal of natural products, Jul, Volume: 56, Issue:7
Dicranin, an antimicrobial and 15-lipoxygenase inhibitor from the moss Dicranum scoparium.
AID334776Antibacterial activity against Streptococcus faecalis NCIB 775 at 75 ug/disk after 24 hrs by disk diffusion assay1993Journal of natural products, Jul, Volume: 56, Issue:7
Dicranin, an antimicrobial and 15-lipoxygenase inhibitor from the moss Dicranum scoparium.
AID334508Antibacterial activity against Bacillus stearothermophilus NCA 1518 at 250 ug/disk after 24 hrs by disk diffusion assay1993Journal of natural products, Jul, Volume: 56, Issue:7
Dicranin, an antimicrobial and 15-lipoxygenase inhibitor from the moss Dicranum scoparium.
AID334504Bactericidal activity against Bacillus stearothermophilus NCA 1518 at 50 to 150 ug/ml upto 4 hrs by liquid culture assay1993Journal of natural products, Jul, Volume: 56, Issue:7
Dicranin, an antimicrobial and 15-lipoxygenase inhibitor from the moss Dicranum scoparium.
AID334519Antibacterial activity against Bacillus cereus NCIB 3329 at 100 ug/disk after 24 hrs by disk diffusion assay1993Journal of natural products, Jul, Volume: 56, Issue:7
Dicranin, an antimicrobial and 15-lipoxygenase inhibitor from the moss Dicranum scoparium.
AID334775Antibacterial activity against Streptococcus faecalis NCIB 775 at 100 ug/disk after 24 hrs by disk diffusion assay1993Journal of natural products, Jul, Volume: 56, Issue:7
Dicranin, an antimicrobial and 15-lipoxygenase inhibitor from the moss Dicranum scoparium.
AID334509Antibacterial activity against Bacillus stearothermophilus NCA 1518 at 125 ug/disk after 24 hrs by disk diffusion assay1993Journal of natural products, Jul, Volume: 56, Issue:7
Dicranin, an antimicrobial and 15-lipoxygenase inhibitor from the moss Dicranum scoparium.
AID334777Antibacterial activity against Streptococcus faecalis NCIB 775 at 50 ug/disk after 24 hrs by disk diffusion assay1993Journal of natural products, Jul, Volume: 56, Issue:7
Dicranin, an antimicrobial and 15-lipoxygenase inhibitor from the moss Dicranum scoparium.
AID334489Antibacterial activity against Pseudomonas putida T-AQ 18/YF18 at 1 mg/disk after 24 hrs by disk diffusion assay1993Journal of natural products, Jul, Volume: 56, Issue:7
Dicranin, an antimicrobial and 15-lipoxygenase inhibitor from the moss Dicranum scoparium.
AID334532Antibacterial activity against Bacillus subtilis NCIB 3610 at 10 ug/disk after 24 hrs by disk diffusion assay1993Journal of natural products, Jul, Volume: 56, Issue:7
Dicranin, an antimicrobial and 15-lipoxygenase inhibitor from the moss Dicranum scoparium.
AID334515Antibacterial activity against Bacillus cereus NCIB 3329 at 1000 ug/disk after 24 hrs by disk diffusion assay1993Journal of natural products, Jul, Volume: 56, Issue:7
Dicranin, an antimicrobial and 15-lipoxygenase inhibitor from the moss Dicranum scoparium.
AID334539Antibacterial activity against Staphylococcus aureus T-AQ 49/YF29 at 50 ug/disk after 24 hrs by disk diffusion assay1993Journal of natural products, Jul, Volume: 56, Issue:7
Dicranin, an antimicrobial and 15-lipoxygenase inhibitor from the moss Dicranum scoparium.
AID334510Antibacterial activity against Bacillus stearothermophilus NCA 1518 at 100 ug/disk after 24 hrs by disk diffusion assay1993Journal of natural products, Jul, Volume: 56, Issue:7
Dicranin, an antimicrobial and 15-lipoxygenase inhibitor from the moss Dicranum scoparium.
AID334531Antibacterial activity against Bacillus subtilis NCIB 3610 at 25 ug/disk after 24 hrs by disk diffusion assay1993Journal of natural products, Jul, Volume: 56, Issue:7
Dicranin, an antimicrobial and 15-lipoxygenase inhibitor from the moss Dicranum scoparium.
AID334771Antibacterial activity against Streptococcus faecalis NCIB 775 at 1000 ug/disk after 24 hrs by disk diffusion assay1993Journal of natural products, Jul, Volume: 56, Issue:7
Dicranin, an antimicrobial and 15-lipoxygenase inhibitor from the moss Dicranum scoparium.
AID334487Antibacterial activity against Salmonella Typhimurium NCIB 10248 at 1 mg/disk after 24 hrs by disk diffusion assay1993Journal of natural products, Jul, Volume: 56, Issue:7
Dicranin, an antimicrobial and 15-lipoxygenase inhibitor from the moss Dicranum scoparium.
AID334538Antibacterial activity against Staphylococcus aureus T-AQ 49/YF29 at 75 ug/disk after 24 hrs by disk diffusion assay1993Journal of natural products, Jul, Volume: 56, Issue:7
Dicranin, an antimicrobial and 15-lipoxygenase inhibitor from the moss Dicranum scoparium.
AID334541Antibacterial activity against Staphylococcus aureus T-AQ 49/YF29 at 10 ug/disk after 24 hrs by disk diffusion assay1993Journal of natural products, Jul, Volume: 56, Issue:7
Dicranin, an antimicrobial and 15-lipoxygenase inhibitor from the moss Dicranum scoparium.
AID334521Antibacterial activity against Bacillus cereus NCIB 3329 at 50 ug/disk after 24 hrs by disk diffusion assay1993Journal of natural products, Jul, Volume: 56, Issue:7
Dicranin, an antimicrobial and 15-lipoxygenase inhibitor from the moss Dicranum scoparium.
AID334773Antibacterial activity against Streptococcus faecalis NCIB 775 at 250 ug/disk after 24 hrs by disk diffusion assay1993Journal of natural products, Jul, Volume: 56, Issue:7
Dicranin, an antimicrobial and 15-lipoxygenase inhibitor from the moss Dicranum scoparium.
AID334501Bactericidal activity against Bacillus cereus NCIB 3329 at 50 ug/ml by liquid culture assay1993Journal of natural products, Jul, Volume: 56, Issue:7
Dicranin, an antimicrobial and 15-lipoxygenase inhibitor from the moss Dicranum scoparium.
AID334534Antibacterial activity against Staphylococcus aureus T-AQ 49/YF29 at 500 ug/disk after 24 hrs by disk diffusion assay1993Journal of natural products, Jul, Volume: 56, Issue:7
Dicranin, an antimicrobial and 15-lipoxygenase inhibitor from the moss Dicranum scoparium.
AID334520Antibacterial activity against Bacillus cereus NCIB 3329 at 75 ug/disk after 24 hrs by disk diffusion assay1993Journal of natural products, Jul, Volume: 56, Issue:7
Dicranin, an antimicrobial and 15-lipoxygenase inhibitor from the moss Dicranum scoparium.
AID334540Antibacterial activity against Staphylococcus aureus T-AQ 49/YF29 at 25 ug/disk after 24 hrs by disk diffusion assay1993Journal of natural products, Jul, Volume: 56, Issue:7
Dicranin, an antimicrobial and 15-lipoxygenase inhibitor from the moss Dicranum scoparium.
AID334502Bactericidal activity against Bacillus cereus NCIB 3329 at 10 ug/ml by liquid culture assay1993Journal of natural products, Jul, Volume: 56, Issue:7
Dicranin, an antimicrobial and 15-lipoxygenase inhibitor from the moss Dicranum scoparium.
AID334506Antibacterial activity against Bacillus stearothermophilus NCA 1518 at 1000 ug/disk after 24 hrs by disk diffusion assay1993Journal of natural products, Jul, Volume: 56, Issue:7
Dicranin, an antimicrobial and 15-lipoxygenase inhibitor from the moss Dicranum scoparium.
AID334774Antibacterial activity against Streptococcus faecalis NCIB 775 at 125 ug/disk after 24 hrs by disk diffusion assay1993Journal of natural products, Jul, Volume: 56, Issue:7
Dicranin, an antimicrobial and 15-lipoxygenase inhibitor from the moss Dicranum scoparium.
AID334772Antibacterial activity against Streptococcus faecalis NCIB 775 at 500 ug/disk after 24 hrs by disk diffusion assay1993Journal of natural products, Jul, Volume: 56, Issue:7
Dicranin, an antimicrobial and 15-lipoxygenase inhibitor from the moss Dicranum scoparium.
AID334537Antibacterial activity against Staphylococcus aureus T-AQ 49/YF29 at 100 ug/disk after 24 hrs by disk diffusion assay1993Journal of natural products, Jul, Volume: 56, Issue:7
Dicranin, an antimicrobial and 15-lipoxygenase inhibitor from the moss Dicranum scoparium.
AID334514Antibacterial activity against Bacillus stearothermophilus NCA 1518 at 10 ug/disk after 24 hrs by disk diffusion assay1993Journal of natural products, Jul, Volume: 56, Issue:7
Dicranin, an antimicrobial and 15-lipoxygenase inhibitor from the moss Dicranum scoparium.
AID334779Antibacterial activity against Streptococcus faecalis NCIB 775 at 10 ug/disk after 24 hrs by disk diffusion assay1993Journal of natural products, Jul, Volume: 56, Issue:7
Dicranin, an antimicrobial and 15-lipoxygenase inhibitor from the moss Dicranum scoparium.
AID334512Antibacterial activity against Bacillus stearothermophilus NCA 1518 at 50 ug/disk after 24 hrs by disk diffusion assay1993Journal of natural products, Jul, Volume: 56, Issue:7
Dicranin, an antimicrobial and 15-lipoxygenase inhibitor from the moss Dicranum scoparium.
AID334507Antibacterial activity against Bacillus stearothermophilus NCA 1518 at 500 ug/disk after 24 hrs by disk diffusion assay1993Journal of natural products, Jul, Volume: 56, Issue:7
Dicranin, an antimicrobial and 15-lipoxygenase inhibitor from the moss Dicranum scoparium.
AID334518Antibacterial activity against Bacillus cereus NCIB 3329 at 125 ug/disk after 24 hrs by disk diffusion assay1993Journal of natural products, Jul, Volume: 56, Issue:7
Dicranin, an antimicrobial and 15-lipoxygenase inhibitor from the moss Dicranum scoparium.
AID334488Antibacterial activity against Pseudomonas aeruginosa ATCC 10145 at 1 mg/disk after 24 hrs by disk diffusion assay1993Journal of natural products, Jul, Volume: 56, Issue:7
Dicranin, an antimicrobial and 15-lipoxygenase inhibitor from the moss Dicranum scoparium.
AID334494Antibacterial activity against Streptococcus faecalis NCIB 775 after 24 hrs by disk diffusion assay1993Journal of natural products, Jul, Volume: 56, Issue:7
Dicranin, an antimicrobial and 15-lipoxygenase inhibitor from the moss Dicranum scoparium.
AID334503Bactericidal activity against sBacillus stearothermophilus NCA 1518 at 200 ug/ml by liquid culture assay1993Journal of natural products, Jul, Volume: 56, Issue:7
Dicranin, an antimicrobial and 15-lipoxygenase inhibitor from the moss Dicranum scoparium.
AID334499Bactericidal activity against Bacillus cereus NCIB 3329 at 150 ug/ml by liquid culture assay1993Journal of natural products, Jul, Volume: 56, Issue:7
Dicranin, an antimicrobial and 15-lipoxygenase inhibitor from the moss Dicranum scoparium.
AID334523Antibacterial activity against Bacillus cereus NCIB 3329 at 10 ug/disk after 24 hrs by disk diffusion assay1993Journal of natural products, Jul, Volume: 56, Issue:7
Dicranin, an antimicrobial and 15-lipoxygenase inhibitor from the moss Dicranum scoparium.
AID334535Antibacterial activity against Staphylococcus aureus T-AQ 49/YF29 at 250 ug/disk after 24 hrs by disk diffusion assay1993Journal of natural products, Jul, Volume: 56, Issue:7
Dicranin, an antimicrobial and 15-lipoxygenase inhibitor from the moss Dicranum scoparium.
AID334536Antibacterial activity against Staphylococcus aureus T-AQ 49/YF29 at 125 ug/disk after 24 hrs by disk diffusion assay1993Journal of natural products, Jul, Volume: 56, Issue:7
Dicranin, an antimicrobial and 15-lipoxygenase inhibitor from the moss Dicranum scoparium.
AID334486Antibacterial activity against Escherichia coli B74-1 at 1 mg/disk after 24 hrs by disk diffusion assay1993Journal of natural products, Jul, Volume: 56, Issue:7
Dicranin, an antimicrobial and 15-lipoxygenase inhibitor from the moss Dicranum scoparium.
AID334524Antibacterial activity against Bacillus subtilis NCIB 3610 at 1000 ug/disk after 24 hrs by disk diffusion assay1993Journal of natural products, Jul, Volume: 56, Issue:7
Dicranin, an antimicrobial and 15-lipoxygenase inhibitor from the moss Dicranum scoparium.
AID334505Bacteriostatic activity against Bacillus stearothermophilus NCA 1518 at 50 to 150 ug/ml after 4 hrs by liquid culture assay1993Journal of natural products, Jul, Volume: 56, Issue:7
Dicranin, an antimicrobial and 15-lipoxygenase inhibitor from the moss Dicranum scoparium.
AID334511Antibacterial activity against Bacillus stearothermophilus NCA 1518 at 75 ug/disk after 24 hrs by disk diffusion assay1993Journal of natural products, Jul, Volume: 56, Issue:7
Dicranin, an antimicrobial and 15-lipoxygenase inhibitor from the moss Dicranum scoparium.
AID334778Antibacterial activity against Streptococcus faecalis NCIB 775 at 25 ug/disk after 24 hrs by disk diffusion assay1993Journal of natural products, Jul, Volume: 56, Issue:7
Dicranin, an antimicrobial and 15-lipoxygenase inhibitor from the moss Dicranum scoparium.
AID334517Antibacterial activity against Bacillus cereus NCIB 3329 at 250 ug/disk after 24 hrs by disk diffusion assay1993Journal of natural products, Jul, Volume: 56, Issue:7
Dicranin, an antimicrobial and 15-lipoxygenase inhibitor from the moss Dicranum scoparium.
AID334490Antibacterial activity against Bacillus stearothermophilus NCA 1518 after 24 hrs by disk diffusion assay1993Journal of natural products, Jul, Volume: 56, Issue:7
Dicranin, an antimicrobial and 15-lipoxygenase inhibitor from the moss Dicranum scoparium.
AID334513Antibacterial activity against Bacillus stearothermophilus NCA 1518 at 25 ug/disk after 24 hrs by disk diffusion assay1993Journal of natural products, Jul, Volume: 56, Issue:7
Dicranin, an antimicrobial and 15-lipoxygenase inhibitor from the moss Dicranum scoparium.
AID334522Antibacterial activity against Bacillus cereus NCIB 3329 at 25 ug/disk after 24 hrs by disk diffusion assay1993Journal of natural products, Jul, Volume: 56, Issue:7
Dicranin, an antimicrobial and 15-lipoxygenase inhibitor from the moss Dicranum scoparium.
AID334525Antibacterial activity against Bacillus subtilis NCIB 3610 at 500 ug/disk after 24 hrs by disk diffusion assay1993Journal of natural products, Jul, Volume: 56, Issue:7
Dicranin, an antimicrobial and 15-lipoxygenase inhibitor from the moss Dicranum scoparium.
AID334533Antibacterial activity against Staphylococcus aureus T-AQ 49/YF29 at 1000 ug/disk after 24 hrs by disk diffusion assay1993Journal of natural products, Jul, Volume: 56, Issue:7
Dicranin, an antimicrobial and 15-lipoxygenase inhibitor from the moss Dicranum scoparium.
AID334500Bactericidal activity against Bacillus cereus NCIB 3329 at 100 ug/ml upto 4 hrs by liquid culture assay1993Journal of natural products, Jul, Volume: 56, Issue:7
Dicranin, an antimicrobial and 15-lipoxygenase inhibitor from the moss Dicranum scoparium.
AID334529Antibacterial activity against Bacillus subtilis NCIB 3610 at 75 ug/disk after 24 hrs by disk diffusion assay1993Journal of natural products, Jul, Volume: 56, Issue:7
Dicranin, an antimicrobial and 15-lipoxygenase inhibitor from the moss Dicranum scoparium.
AID334527Antibacterial activity against Bacillus subtilis NCIB 3610 at 125 ug/disk after 24 hrs by disk diffusion assay1993Journal of natural products, Jul, Volume: 56, Issue:7
Dicranin, an antimicrobial and 15-lipoxygenase inhibitor from the moss Dicranum scoparium.
AID334516Antibacterial activity against Bacillus cereus NCIB 3329 at 500 ug/disk after 24 hrs by disk diffusion assay1993Journal of natural products, Jul, Volume: 56, Issue:7
Dicranin, an antimicrobial and 15-lipoxygenase inhibitor from the moss Dicranum scoparium.
AID334528Antibacterial activity against Bacillus subtilis NCIB 3610 at 100 ug/disk after 24 hrs by disk diffusion assay1993Journal of natural products, Jul, Volume: 56, Issue:7
Dicranin, an antimicrobial and 15-lipoxygenase inhibitor from the moss Dicranum scoparium.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's3 (50.00)18.2507
2000's1 (16.67)29.6817
2010's2 (33.33)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
catechol
[no description available]		1.9810catecholsallelochemical;
genotoxin;
plant metabolite
5,8,11,14-eicosatetraynoic acid
5,8,11,14-Eicosatetraynoic Acid: A 20-carbon unsaturated fatty acid containing 4 alkyne bonds. It inhibits the enzymatic conversion of arachidonic acid to prostaglandins E(2) and F(2a).		1.9810long-chain fatty acid
arachidonic acid
icosa-5,8,11,14-tetraenoic acid : Any icosatetraenoic acid with the double bonds at positions 5, 8, 11 and 14.. arachidonate : A long-chain fatty acid anion resulting from the removal of a proton from the carboxy group of arachidonic acid.		2.3820icosa-5,8,11,14-tetraenoic acid;
long-chain fatty acid;
omega-6 fatty acid		Daphnia galeata metabolite;
EC 3.1.1.1 (carboxylesterase) inhibitor;
human metabolite;
mouse metabolite
palmitoleic acid
hexadecenoate : A long-chain unsaturated fatty acid anion that is the conjugate base of hexadecenoic acid, obtained by deprotonation of the carboxy group; major species at pH 7.3.		1.9810hexadec-9-enoic acidalgal metabolite;
Daphnia galeata metabolite;
EC 3.1.1.1 (carboxylesterase) inhibitor;
Escherichia coli metabolite;
human blood serum metabolite
stearidonic acid
[no description available]		2.3920long-chain fatty acid;
octadecatetraenoic acid;
omega-3 fatty acid		Daphnia galeata metabolite;
mouse metabolite;
plant metabolite
12-hydroxy-5,8,10-heptadecatrienoic acid
12-hydroxy-5,8,10-heptadecatrienoic acid: metabolite of arachidonic acid in blood platelet suspension; RN given refers to cpd without isomeric designation		2.3820hydroxy polyunsaturated fatty acid;
long-chain fatty acid;
trienoic fatty acid		metabolite
12-hydroxy-5,8,10,14-eicosatetraenoic acid
12-Hydroxy-5,8,10,14-eicosatetraenoic Acid: A lipoxygenase metabolite of ARACHIDONIC ACID. It is a highly selective ligand used to label mu-opioid receptors in both membranes and tissue sections. The 12-S-HETE analog has been reported to augment tumor cell metastatic potential through activation of protein kinase C. (J Pharmacol Exp Ther 1995; 274(3):1545-51; J Natl Cancer Inst 1994; 86(15):1145-51)		2.3820
ConditionIndicatedRelationship StrengthStudiesTrials
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