Compounds > clovanemagnolol
Page last updated: 2024-11-12

clovanemagnolol

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

clovanemagnolol: has neuroregenerative activity; isolated from Magnolina obovata [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID10323149
CHEMBL ID1818475
SCHEMBL ID4443250
MeSH IDM0547213

Synonyms (4)

Synonym
clovanemagnolol
CHEMBL1818475
SCHEMBL4443250
(1s,2s,5s,8r,9r)-2-[2-(2-hydroxy-5-prop-2-enylphenyl)-4-prop-2-enylphenoxy]-4,4,8-trimethyltricyclo[6.3.1.01,5]dodecan-9-ol

Research Excerpts

Effects

ExcerptReferenceRelevance
"Clovanemagnolol has been shown to be a potent neurotrophic agent, promoting neuronal growth at concentrations of 10 nM."( Neuronal growth promoting sesquiterpene-neolignans; syntheses and biological studies.
Camelio, AM; Cheng, X; Harzdorf, N; Kang, D; Khaing, Z; Schmidt, CE; Shaw, T; Siegel, D, 2012)		1.1
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (9)

Assay IDTitleYearJournalArticle
AID613706Neurotrophic activity in isolated embryonic mouse brain Hippocampal neurons assessed as induction of neurite outgrowth at 0.1 uM after 48 hrs relative to control2011Bioorganic & medicinal chemistry letters, Aug-15, Volume: 21, Issue:16
Hippocampal and cortical neuronal growth mediated by the small molecule natural product clovanemagnolol.
AID613710Neurotrophic activity in isolated embryonic mouse embryonic Cortical neurons assessed as induction of neurite outgrowth at 0.1 uM after 48 hrs relative to control2011Bioorganic & medicinal chemistry letters, Aug-15, Volume: 21, Issue:16
Hippocampal and cortical neuronal growth mediated by the small molecule natural product clovanemagnolol.
AID613712Neurotrophic activity in isolated embryonic mouse embryonic Cortical neurons assessed as induction of neurite outgrowth after 48 hrs relative to control2011Bioorganic & medicinal chemistry letters, Aug-15, Volume: 21, Issue:16
Hippocampal and cortical neuronal growth mediated by the small molecule natural product clovanemagnolol.
AID613705Neurotrophic activity in isolated embryonic mouse brain Hippocampal neurons assessed as induction of neurite outgrowth at 0.01 uM after 48 hrs relative to control2011Bioorganic & medicinal chemistry letters, Aug-15, Volume: 21, Issue:16
Hippocampal and cortical neuronal growth mediated by the small molecule natural product clovanemagnolol.
AID613708Neurotrophic activity in isolated embryonic mouse brain Hippocampal neurons assessed as induction of neurite outgrowth after 48 hrs relative to control2011Bioorganic & medicinal chemistry letters, Aug-15, Volume: 21, Issue:16
Hippocampal and cortical neuronal growth mediated by the small molecule natural product clovanemagnolol.
AID613707Neurotrophic activity in isolated embryonic mouse brain Hippocampal neurons assessed as induction of neurite outgrowth at 1 uM after 48 hrs relative to control2011Bioorganic & medicinal chemistry letters, Aug-15, Volume: 21, Issue:16
Hippocampal and cortical neuronal growth mediated by the small molecule natural product clovanemagnolol.
AID613709Neurotrophic activity in isolated embryonic mouse embryonic Cortical neurons assessed as induction of neurite outgrowth at 0.01 uM after 48 hrs relative to control2011Bioorganic & medicinal chemistry letters, Aug-15, Volume: 21, Issue:16
Hippocampal and cortical neuronal growth mediated by the small molecule natural product clovanemagnolol.
AID613711Neurotrophic activity in isolated embryonic mouse embryonic Cortical neurons assessed as induction of neurite outgrowth at 1 uM after 48 hrs relative to control2011Bioorganic & medicinal chemistry letters, Aug-15, Volume: 21, Issue:16
Hippocampal and cortical neuronal growth mediated by the small molecule natural product clovanemagnolol.
AID613704Increase in choline acetyltransferase activity in rat brain neurons at 1 mM after 10 days relative to control2011Bioorganic & medicinal chemistry letters, Aug-15, Volume: 21, Issue:16
Hippocampal and cortical neuronal growth mediated by the small molecule natural product clovanemagnolol.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's6 (100.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 13.26

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index13.26 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index5.21 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (13.26)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
hydrogen
Hydrogen: The first chemical element in the periodic table with atomic symbol H, and atomic number 1. Protium (atomic weight 1) is by far the most common hydrogen isotope. Hydrogen also exists as the stable isotope DEUTERIUM (atomic weight 2) and the radioactive isotope TRITIUM (atomic weight 3). Hydrogen forms into a diatomic molecule at room temperature and appears as a highly flammable colorless and odorless gas.. dihydrogen : An elemental molecule consisting of two hydrogens joined by a single bond.		2.0810elemental hydrogen;
elemental molecule;
gas molecular entity		antioxidant;
electron donor;
food packaging gas;
fuel;
human metabolite
mesitylene
mesitylene: structure. 1,3,5-trimethylbenzene : A trimethylbenzene carrying methyl substituents at positions 1, 3 and 5.		2.0810trimethylbenzene
tocopherols
[no description available]		2.0810
magnolol
[no description available]		7.0610biphenyls
lignans
Lignans: A class of dibenzylbutane derivatives which occurs in higher plants and in fluids (bile, serum, urine, etc.) in man and other animals. These compounds, which have a potential anti-cancer role, can be synthesized in vitro by human fecal flora. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)		2.0710
tacrolimus
Tacrolimus: A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation in vitro.. tacrolimus (anhydrous) : A macrolide lactam containing a 23-membered lactone ring, originally isolated from the fermentation broth of a Japanese soil sample that contained the bacteria Streptomyces tsukubaensis.		2.0810macrolide lactambacterial metabolite;
immunosuppressive agent
sesquiterpenes
[no description available]		3.3260
caryophyllene
caryophyllene: RN given refers to cpd without isomeric designation; structure given in first source		2.0510
ConditionIndicatedRelationship StrengthStudiesTrials