Page last updated: 2024-11-12
clovanemagnolol
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
Related Conditions
Protein Interactions
Research Growth
Market Indicators
Description
clovanemagnolol: has neuroregenerative activity; isolated from Magnolina obovata [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
| ID Source | ID |
|---|---|
| PubMed CID | 10323149 |
| CHEMBL ID | 1818475 |
| SCHEMBL ID | 4443250 |
| MeSH ID | M0547213 |
Synonyms (4)
| Synonym |
|---|
| clovanemagnolol |
| CHEMBL1818475 |
| SCHEMBL4443250 |
| (1s,2s,5s,8r,9r)-2-[2-(2-hydroxy-5-prop-2-enylphenyl)-4-prop-2-enylphenoxy]-4,4,8-trimethyltricyclo[6.3.1.01,5]dodecan-9-ol |
Research Excerpts
Effects
| Excerpt | Reference | Relevance |
|---|---|---|
| "Clovanemagnolol has been shown to be a potent neurotrophic agent, promoting neuronal growth at concentrations of 10 nM." | ( Neuronal growth promoting sesquiterpene-neolignans; syntheses and biological studies. Camelio, AM; Cheng, X; Harzdorf, N; Kang, D; Khaing, Z; Schmidt, CE; Shaw, T; Siegel, D, 2012) | 1.1 |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Bioassays (9)
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID613706 | Neurotrophic activity in isolated embryonic mouse brain Hippocampal neurons assessed as induction of neurite outgrowth at 0.1 uM after 48 hrs relative to control | 2011 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 21, Issue:16 | Hippocampal and cortical neuronal growth mediated by the small molecule natural product clovanemagnolol. |
| AID613710 | Neurotrophic activity in isolated embryonic mouse embryonic Cortical neurons assessed as induction of neurite outgrowth at 0.1 uM after 48 hrs relative to control | 2011 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 21, Issue:16 | Hippocampal and cortical neuronal growth mediated by the small molecule natural product clovanemagnolol. |
| AID613712 | Neurotrophic activity in isolated embryonic mouse embryonic Cortical neurons assessed as induction of neurite outgrowth after 48 hrs relative to control | 2011 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 21, Issue:16 | Hippocampal and cortical neuronal growth mediated by the small molecule natural product clovanemagnolol. |
| AID613705 | Neurotrophic activity in isolated embryonic mouse brain Hippocampal neurons assessed as induction of neurite outgrowth at 0.01 uM after 48 hrs relative to control | 2011 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 21, Issue:16 | Hippocampal and cortical neuronal growth mediated by the small molecule natural product clovanemagnolol. |
| AID613708 | Neurotrophic activity in isolated embryonic mouse brain Hippocampal neurons assessed as induction of neurite outgrowth after 48 hrs relative to control | 2011 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 21, Issue:16 | Hippocampal and cortical neuronal growth mediated by the small molecule natural product clovanemagnolol. |
| AID613707 | Neurotrophic activity in isolated embryonic mouse brain Hippocampal neurons assessed as induction of neurite outgrowth at 1 uM after 48 hrs relative to control | 2011 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 21, Issue:16 | Hippocampal and cortical neuronal growth mediated by the small molecule natural product clovanemagnolol. |
| AID613709 | Neurotrophic activity in isolated embryonic mouse embryonic Cortical neurons assessed as induction of neurite outgrowth at 0.01 uM after 48 hrs relative to control | 2011 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 21, Issue:16 | Hippocampal and cortical neuronal growth mediated by the small molecule natural product clovanemagnolol. |
| AID613711 | Neurotrophic activity in isolated embryonic mouse embryonic Cortical neurons assessed as induction of neurite outgrowth at 1 uM after 48 hrs relative to control | 2011 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 21, Issue:16 | Hippocampal and cortical neuronal growth mediated by the small molecule natural product clovanemagnolol. |
| AID613704 | Increase in choline acetyltransferase activity in rat brain neurons at 1 mM after 10 days relative to control | 2011 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 21, Issue:16 | Hippocampal and cortical neuronal growth mediated by the small molecule natural product clovanemagnolol. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
Research
Studies (6)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 6 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
Market Indicators
Research Demand Index: 13.26
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (13.26) All Compounds (24.57) |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 6 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||