clovanemagnolol and caryophyllene

Separate short and modular syntheses of the isomeric natural products caryolanemagnolol and clovanemagnolol have been achieved starting from commercially available (-)-caryophyllene. The postulated biosynthetic pathways guided the syntheses of the neuroregenerative small molecules allowing their assembly in as few as two steps.

Topics: Biological Products; Biomimetics; Molecular Conformation; Nerve Growth Factors; Phenols; Polycyclic Sesquiterpenes; Sesquiterpenes; Stereoisomerism