FK506 binding

Definition

Target type: molecularfunction

Binding to a 23-membered macrolide lactone FK506. [GOC:jl]

FK506 binding protein (FKBP) is a molecular chaperone that plays a crucial role in protein folding and signaling pathways. It derives its name from its ability to bind the immunosuppressant drug FK506. FKBP exhibits diverse functions, including:'

'1. **Peptidyl-prolyl cis-trans isomerase (PPIase) activity:** FKBP catalyzes the isomerization of proline residues within proteins, facilitating the transition between cis and trans conformations. This activity is essential for proper protein folding and the formation of functional protein structures.'

'2. **Chaperone activity:** FKBP interacts with unfolded or misfolded proteins, preventing their aggregation and promoting their correct folding. This chaperone function is crucial for maintaining cellular homeostasis and preventing protein misfolding-related diseases.'

'3. **Signaling pathway regulation:** FKBP participates in various signaling pathways, including the calcineurin pathway. FK506 binding to FKBP inhibits calcineurin activity, a phosphatase that plays a role in immune responses and cellular growth. This inhibition is the basis for the immunosuppressive effects of FK506 in transplantation.'

'4. **Protein-protein interactions:** FKBP interacts with a variety of proteins, including the glucocorticoid receptor, the heat shock protein 90 (Hsp90), and other chaperones. These interactions contribute to diverse cellular processes, such as hormone signaling, protein stability, and cellular stress response.'

'5. **Regulation of gene expression:** FKBP can influence gene expression by interacting with transcription factors and other regulatory proteins. This activity contributes to the modulation of cellular processes and the response to environmental cues.'

'The molecular function of FKBP is thus multifaceted and essential for maintaining cellular integrity, regulating signaling pathways, and facilitating proper protein folding.'
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Proteins (6)

Compounds (16)