achyrofuran has been researched along with Diabetes-Mellitus--Type-2* in 3 studies
3 other study(ies) available for achyrofuran and Diabetes-Mellitus--Type-2
| Article | Year |
|---|---|
Diverse alkanones by catalytic carbon insertion into the formyl C-H bond. Concise access to the natural precursor of achyrofuran.
Over a century ago, the first reactions of diazomethane with aldehydes delivered methyl ketones. In the interim, aldehydes have been homologated with trimethylsilyldiazomethane, diazoacetates, and aryldiazomethanes, on rare occasion with catalysis. This work describes a mild procedure for convergent ketone assembly from nonstabilized diazoalkanes, including examples of chiral ketone synthesis with disubstituted (internal) nucleophiles. The method's remarkable tolerance to steric crowding is showcased in a simple approach to achyrofuran, a complex dibenzofuran. Topics: Carbon; Catalysis; Diabetes Mellitus, Type 2; Drug Design; Furans; Hypoglycemic Agents; Ketones | 2009 |
[Erection help from the rain forest?].
Topics: Achyrocline; Administration, Oral; Animals; Diabetes Mellitus, Type 2; Disease Models, Animal; Erectile Dysfunction; Female; Furans; Guinea Pigs; Humans; Male; Medicine, Traditional; Mice; Oxidative Stress; Phytotherapy; Plant Extracts; Plant Preparations; Plants, Medicinal; Time Factors | 2004 |
Achyrofuran, a new antihyperglycemic dibenzofuran from the South American medicinal plant Achyrocline satureioides.
A new prenylated dibenzofuran, achyrofuran (2), was isolated from an extract of Achyrocline satureioides by bioassay-guided fractionation using the db/db mouse model for type 2 diabetes. Compound 2significantly lowered blood glucose levels in this model when administered orally at 20 mg/kg q.d. Topics: Animals; Asteraceae; Chromatography, Thin Layer; Diabetes Mellitus, Type 2; Furans; Hypoglycemic Agents; Mass Spectrometry; Mice; Mice, Inbred Strains; Models, Animal; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Peru; Plants, Medicinal; Pyrones; Spectrophotometry, Ultraviolet; Structure-Activity Relationship | 2002 |