Compounds > acerogenin a
Page last updated: 2024-11-12

acerogenin a

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

acerogenin A: stimulates osteoblast differentiation; isolated from Acer nikoense [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

FloraRankFlora DefinitionFamilyFamily Definition
AcergenusA plant genus of the family SAPINDACEAE, best known for trees with palmately lobed leaves.[MeSH]SapindaceaeThe soapberry plant family of the order Sapindales, subclass Rosidae, class Magnoliopsida. Some members contain SAPONINS.[MeSH]

Cross-References

ID SourceID
PubMed CID12000158
CHEMBL ID516665
SCHEMBL ID10048511
MeSH IDM0557446

Synonyms (7)

Synonym
CHEMBL516665
acerogenin a
SCHEMBL10048511
60503-28-8
(12r)-2-oxatricyclo[13.2.2.13,7]eicosa-3,5,7(20),15,17,18-hexaene-4,12-diol
DTXSID801143415
(12r)-2-oxatricyclo[13.2.2.13,7]icosa-1(17),3,5,7(20),15,18-hexaene-4,12-diol

Research Excerpts

Treatment

ExcerptReferenceRelevance
"The acerogenin A treatment for 3days increased Bmp-2, Bmp-4, and Bmp-7 mRNA expression levels in MC3T3-E1 cells."( Acerogenin A, a natural compound isolated from Acer nikoense Maxim, stimulates osteoblast differentiation through bone morphogenetic protein action.
Akihisa, T; Amagasa, T; Ichikawa, S; Kihara, T; Lee, JW; Michi, Y; Woo, JT; Yamaguchi, A; Yonezawa, T, 2011)		2.29
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (19)

Assay IDTitleYearJournalArticle
AID598745Induction of osteogenesis in mouse MC3T3-E1 cells assessed as increase in alkaline phosphatase activity at 30 uM after 6 days in presence of 0.1 uM LDN-193289 BMP receptor kinase inhibitor2011Bioorganic & medicinal chemistry letters, Jun-01, Volume: 21, Issue:11
Osteogenic activity of diphenyl ether-type cyclic diarylheptanoids derived from Acer nikoense.
AID598714Induction of cells differentiation in mouse MC3T3-E1 cells assessed as increase in osteocalcin production after 14 days by EIA2011Bioorganic & medicinal chemistry letters, Jun-01, Volume: 21, Issue:11
Osteogenic activity of diphenyl ether-type cyclic diarylheptanoids derived from Acer nikoense.
AID332307Inhibition of LPS-induced NO production in ddY mouse peritoneal macrophages at 1 uM by Griess reagent method2003Journal of natural products, Jan, Volume: 66, Issue:1
Structures of new cyclic diarylheptanoids and inhibitors of nitric oxide production from Japanese folk medicine Acer nikoense.
AID332313Cytotoxicity against ddY mouse macrophages after 20 hrs by MTT assay2003Journal of natural products, Jan, Volume: 66, Issue:1
Structures of new cyclic diarylheptanoids and inhibitors of nitric oxide production from Japanese folk medicine Acer nikoense.
AID598747Induction of osteoclast differentiation in mouse RAW264 cells assessed as TRAP activity2011Bioorganic & medicinal chemistry letters, Jun-01, Volume: 21, Issue:11
Osteogenic activity of diphenyl ether-type cyclic diarylheptanoids derived from Acer nikoense.
AID598743Induction of cells differentiation in mouse MC3T3-E1 cells assessed as increase in mineralization after 14 days by Alizarin Red S staining2011Bioorganic & medicinal chemistry letters, Jun-01, Volume: 21, Issue:11
Osteogenic activity of diphenyl ether-type cyclic diarylheptanoids derived from Acer nikoense.
AID459758Inhibition of human SGLT2 expressed in COS1 cells assessed as [14C]methyl-alpha-D-glucopyranoside uptake at 50 uM2010Bioorganic & medicinal chemistry letters, Feb-01, Volume: 20, Issue:3
Cyclic diarylheptanoids as Na+-glucose cotransporter (SGLT) inhibitors from Acer nikoense.
AID598715Induction of osteogenesis in mouse MC3T3-E1 cells assessed as cell differentiation at 30 uM after 6 days by alkaline phosphatase activity assay2011Bioorganic & medicinal chemistry letters, Jun-01, Volume: 21, Issue:11
Osteogenic activity of diphenyl ether-type cyclic diarylheptanoids derived from Acer nikoense.
AID598716Cytotoxicity against mouse MC3T3-E1 cells at 30 uM after 6 days2011Bioorganic & medicinal chemistry letters, Jun-01, Volume: 21, Issue:11
Osteogenic activity of diphenyl ether-type cyclic diarylheptanoids derived from Acer nikoense.
AID598741Induction of osteogenesis in mouse MC3T3-E1 cells assessed as increase in alkaline phosphatase activity after 6 days2011Bioorganic & medicinal chemistry letters, Jun-01, Volume: 21, Issue:11
Osteogenic activity of diphenyl ether-type cyclic diarylheptanoids derived from Acer nikoense.
AID332311Inhibition of LPS-induced NO production in ddY mouse peritoneal macrophages at 100 uM by Griess reagent method2003Journal of natural products, Jan, Volume: 66, Issue:1
Structures of new cyclic diarylheptanoids and inhibitors of nitric oxide production from Japanese folk medicine Acer nikoense.
AID332310Inhibition of LPS-induced NO production in ddY mouse peritoneal macrophages at 30 uM by Griess reagent method2003Journal of natural products, Jan, Volume: 66, Issue:1
Structures of new cyclic diarylheptanoids and inhibitors of nitric oxide production from Japanese folk medicine Acer nikoense.
AID332308Inhibition of LPS-induced NO production in ddY mouse peritoneal macrophages at 3 uM by Griess reagent method2003Journal of natural products, Jan, Volume: 66, Issue:1
Structures of new cyclic diarylheptanoids and inhibitors of nitric oxide production from Japanese folk medicine Acer nikoense.
AID598746Induction of osteogenesis in mouse MC3T3-E1 cells assessed as increase in alkaline phosphatase activity at 30 uM after 6 days in presence of 5 uM SB203580 p38 MAPK inhibitor2011Bioorganic & medicinal chemistry letters, Jun-01, Volume: 21, Issue:11
Osteogenic activity of diphenyl ether-type cyclic diarylheptanoids derived from Acer nikoense.
AID332309Inhibition of LPS-induced NO production in ddY mouse peritoneal macrophages at 10 uM by Griess reagent method2003Journal of natural products, Jan, Volume: 66, Issue:1
Structures of new cyclic diarylheptanoids and inhibitors of nitric oxide production from Japanese folk medicine Acer nikoense.
AID459759Inhibition of human SGLT1 expressed in COS1 cells assessed as [14C]methyl-alpha-D-glucopyranoside uptake at 50 uM2010Bioorganic & medicinal chemistry letters, Feb-01, Volume: 20, Issue:3
Cyclic diarylheptanoids as Na+-glucose cotransporter (SGLT) inhibitors from Acer nikoense.
AID332312Inhibition of LPS-induced NO production in ddY mouse peritoneal macrophages by Griess reagent method2003Journal of natural products, Jan, Volume: 66, Issue:1
Structures of new cyclic diarylheptanoids and inhibitors of nitric oxide production from Japanese folk medicine Acer nikoense.
AID598742Induction of osteogenesis in mouse primary calvarial cells assessed as increase in alkaline phosphatase activity measured by ALP staining after 14 days2011Bioorganic & medicinal chemistry letters, Jun-01, Volume: 21, Issue:11
Osteogenic activity of diphenyl ether-type cyclic diarylheptanoids derived from Acer nikoense.
AID598744Induction of osteogenesis in mouse MC3T3-E1 cells assessed as increase in alkaline phosphatase activity at 30 uM after 6 days in presence of 50 ng/ml noggin BMP antagonist2011Bioorganic & medicinal chemistry letters, Jun-01, Volume: 21, Issue:11
Osteogenic activity of diphenyl ether-type cyclic diarylheptanoids derived from Acer nikoense.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (20.00)29.6817
2010's4 (80.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.84

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.84 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.63 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.84)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
phlorhizin
[no description available]		2.0510aryl beta-D-glucoside;
dihydrochalcones;
monosaccharide derivative		antioxidant;
plant metabolite
catechin
Catechin: An antioxidant flavonoid, occurring especially in woody plants as both (+)-catechin and (-)-epicatechin (cis) forms.. catechin : Members of the class of hydroxyflavan that have a flavan-3-ol skeleton and its substituted derivatives.. rac-catechin : A racemate comprising equimolar amounts of (+)- and (-)-catechin. (+)-catechin : The (+)-enantiomer of catechin and a polyphenolic antioxidant plant metabolite.		2.0610catechinantioxidant;
plant metabolite
glutamic acid
Glutamic Acid: A non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in the CENTRAL NERVOUS SYSTEM.. glutamic acid : An alpha-amino acid that is glutaric acid bearing a single amino substituent at position 2.		2.1110glutamic acid;
glutamine family amino acid;
L-alpha-amino acid;
proteinogenic amino acid		Escherichia coli metabolite;
ferroptosis inducer;
micronutrient;
mouse metabolite;
neurotransmitter;
nutraceutical
ConditionIndicatedRelationship StrengthStudiesTrials