| Assay ID | Title | Year | Journal | Article |
|---|
| AID1506534 | Displacement of [3H]PK11195 from human wild type TSPO expressed in HEK293T cell membranes after 90 mins by scintillation counting method | 2017 | MedChemComm, Jan-01, Volume: 8, Issue:1
| Determination and reduction of translocator protein (TSPO) ligand rs6971 discrimination. |
| AID712218 | Displacement of [11C]-PK-11195 from TPSO in Sprague-Dawley rat brain homogenate after 30 mins by gamma counting | 2011 | Journal of medicinal chemistry, Sep-08, Volume: 54, Issue:17
| Synthesis and evaluation of novel carbon-11 labeled oxopurine analogues for positron emission tomography imaging of translocator protein (18 kDa) in peripheral organs. |
| AID1506538 | Antiproliferative activity against HEK293T cells expressing human wild type TSPO after 48 hrs by BrdU incorporation assay | 2017 | MedChemComm, Jan-01, Volume: 8, Issue:1
| Determination and reduction of translocator protein (TSPO) ligand rs6971 discrimination. |
| AID415744 | Displacement of [11C]PK11195 from PBR receptor in rat brain membrane | 2009 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 19, Issue:6
| [18F]FEAC and [18F]FEDAC: Two novel positron emission tomography ligands for peripheral-type benzodiazepine receptor in the brain. |
| AID626991 | Antianxiety activity in mouse assessed as increase in time spent in illuminated area at 1 mg/kg, po by light/dark box test (Rvb = 116.4 +/- 7.5 sec) | 2011 | Journal of medicinal chemistry, Oct-27, Volume: 54, Issue:20
| Synthesis and structure-activity relationship studies in translocator protein ligands based on a pyrazolo[3,4-b]quinoline scaffold. |
| AID712219 | Lipophilicity, log D of the compound in octanol-phosphate buffer at pH 7.4 by shake flask method | 2011 | Journal of medicinal chemistry, Sep-08, Volume: 54, Issue:17
| Synthesis and evaluation of novel carbon-11 labeled oxopurine analogues for positron emission tomography imaging of translocator protein (18 kDa) in peripheral organs. |
| AID415746 | Displacement of [11C]flumazenil from CBR receptor in rat brain membrane | 2009 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 19, Issue:6
| [18F]FEAC and [18F]FEDAC: Two novel positron emission tomography ligands for peripheral-type benzodiazepine receptor in the brain. |
| AID1506536 | Cytotoxicity against HEK293T cells expressing human TSPO A147T mutant assessed as decrease in cell viability after 48 hrs by CellTiter blue assay | 2017 | MedChemComm, Jan-01, Volume: 8, Issue:1
| Determination and reduction of translocator protein (TSPO) ligand rs6971 discrimination. |
| AID1506533 | Selectivity ratio of Ki for human TSPO A147T mutant to Ki for human wild type TSPO | 2017 | MedChemComm, Jan-01, Volume: 8, Issue:1
| Determination and reduction of translocator protein (TSPO) ligand rs6971 discrimination. |
| AID1506535 | Displacement of [3H]PK11195 from human TSPO A147T mutant expressed in HEK293T cell membranes after 90 mins by scintillation counting method | 2017 | MedChemComm, Jan-01, Volume: 8, Issue:1
| Determination and reduction of translocator protein (TSPO) ligand rs6971 discrimination. |
| AID1506537 | Selectivity ratio of IC50 for HEK293T cells expressing human TSPO A147T mutant assessed as decrease in cell viability to IC50 for HEK293T cells expressing human wild type TSPO assessed as decrease in cell viability | 2017 | MedChemComm, Jan-01, Volume: 8, Issue:1
| Determination and reduction of translocator protein (TSPO) ligand rs6971 discrimination. |
| AID1506539 | Antiproliferative activity against HEK293T cells expressing human TSPO A147T mutant after 48 hrs by BrdU incorporation assay | 2017 | MedChemComm, Jan-01, Volume: 8, Issue:1
| Determination and reduction of translocator protein (TSPO) ligand rs6971 discrimination. |
| AID1506541 | Ratio of Ki for displacement of [3H]PK11195 from human brain TSPO isolated from low affinity binder patient to Ki for [3H]PK11195 from human brain TSPO isolated from high affinity binder patient | 2017 | MedChemComm, Jan-01, Volume: 8, Issue:1
| Determination and reduction of translocator protein (TSPO) ligand rs6971 discrimination. |
| AID1506532 | Cytotoxicity against HEK293T cells expressing human wild type TSPO assessed as decrease in cell viability after 48 hrs by CellTiter blue assay | 2017 | MedChemComm, Jan-01, Volume: 8, Issue:1
| Determination and reduction of translocator protein (TSPO) ligand rs6971 discrimination. |
| AID626988 | Antianxiety activity in mouse assessed as increase in time spent in illuminated area at 3 mg/kg, po after 30 mins by light/dark box test (Rvb = 116.4 +/- 7.5 sec) | 2011 | Journal of medicinal chemistry, Oct-27, Volume: 54, Issue:20
| Synthesis and structure-activity relationship studies in translocator protein ligands based on a pyrazolo[3,4-b]quinoline scaffold. |
| AID626989 | Antianxiety activity in mouse assessed as increase in time spent in illuminated area at 10 mg/kg, po after 30 mins by light/dark box test (Rvb = 116.4 +/- 7.5 sec) | 2011 | Journal of medicinal chemistry, Oct-27, Volume: 54, Issue:20
| Synthesis and structure-activity relationship studies in translocator protein ligands based on a pyrazolo[3,4-b]quinoline scaffold. |
| AID415747 | Distribution coefficient, log D in octanol/phosphate buffer at pH 7.4 by shaking flask method | 2009 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 19, Issue:6
| [18F]FEAC and [18F]FEDAC: Two novel positron emission tomography ligands for peripheral-type benzodiazepine receptor in the brain. |
| AID1296008 | Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening | 2020 | SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
| Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening. |
| AID1346986 | P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1347159 | Primary screen GU Rhodamine qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1346987 | P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1347160 | Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |