Compounds > 5-bromotryptophan
Page last updated: 2024-11-07

5-bromotryptophan

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

5-bromotryptophan: RN given refers to (DL)-isomer; RN for cpd without isomeric designation not available 1/91; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

5-bromotryptophan : A non-proteinogenic alpha-amino acid that is tryptophan in which the hydrogen at position 5 on the indole ring is replaced by a bromo group. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID644329
CHEMBL ID320227
SCHEMBL ID454983
MeSH IDM0182763

Synonyms (26)

Synonym
l-tryptophan, 5-bromo- (9ci)
25197-99-3
5-bromo-l-tryptophan
l-tryptophan, 5-bromo-
5-bromo-tryptophan
tryptophan, 5-bromo-, l- (8ci)
5-bromotryptophan
CHEMBL320227
(2s)-2-amino-3-(5-bromo-1h-indol-3-yl)propanoic acid
(s)-2-amino-3-(5-bromo-1h-indol-3-yl)propanoic acid
AKOS016003655
SCHEMBL454983
tryptophan, 5-bromo-
CS-B1055
5brw
mfcd06796707
(s)-2-amino-3-(5-bromo-1h-indol-3-yl)propanoicacid
KZDNJQUJBMDHJW-VIFPVBQESA-N
DS-17331
A1-29369
A877670
EN300-6472318
DTXSID201315301
HY-20897A
64X ,
PD171415
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (1)

Assay IDTitleYearJournalArticle
AID220533Inhibitory activity against aggregation of deoxy-HbS using CSAT assay1990Journal of medicinal chemistry, Dec, Volume: 33, Issue:12
Hemoglobin S antigelation agents based on 5-bromotryptophan with potential for sickle cell anemia.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's4 (80.00)18.2507
2000's1 (20.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
hydroxyproline
Hydroxyproline: A hydroxylated form of the imino acid proline. A deficiency in ASCORBIC ACID can result in impaired hydroxyproline formation.. hydroxyproline : A proline derivative that is proline substituted by at least one hydroxy group.		2.01104-hydroxyproline;
L-alpha-amino acid zwitterion		human metabolite;
mouse metabolite;
plant metabolite
tryptophan
Tryptophan: An essential amino acid that is necessary for normal growth in infants and for NITROGEN balance in adults. It is a precursor of INDOLE ALKALOIDS in plants. It is a precursor of SEROTONIN (hence its use as an antidepressant and sleep aid). It can be a precursor to NIACIN, albeit inefficiently, in mammals.. tryptophan : An alpha-amino acid that is alanine bearing an indol-3-yl substituent at position 3.		3.0850erythrose 4-phosphate/phosphoenolpyruvate family amino acid;
L-alpha-amino acid zwitterion;
L-alpha-amino acid;
proteinogenic amino acid;
tryptophan zwitterion;
tryptophan		antidepressant;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
Saccharomyces cerevisiae metabolite
Trp-Trp
tryptophyltryptophan: an antigelation agent. Trp-Trp : A dipeptide formed from two L-tryptophan residues.		1.9710dipeptideMycoplasma genitalium metabolite
ConditionIndicatedRelationship StrengthStudiesTrials
HbS Disease
[description not available]		01.9710
Anemia, Sickle Cell
A disease characterized by chronic hemolytic anemia, episodic painful crises, and pathologic involvement of many organs. It is the clinical expression of homozygosity for hemoglobin S.		01.9710
Sensitivity and Specificity
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)		02.0110