Compounds > 4-dimethylaminobenzylamine
Page last updated: 2024-11-06

4-dimethylaminobenzylamine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

4-Dimethylaminobenzylamine, also known as N,N-dimethyl-4-aminobenzylamine, is a chemical compound that has garnered attention due to its structural similarity to the neurotransmitter dopamine. Its potential as a precursor for the synthesis of various pharmaceutical agents, including antipsychotics and antidepressants, has driven research interest. This compound is also explored for its potential as a catalyst in organic reactions, particularly in the synthesis of polymers and other organic molecules. While there is no specific information on its effects or importance in the context of human health, its structural similarity to dopamine suggests potential interactions with the dopaminergic system, making it a subject of further investigation.'

Cross-References

ID SourceID
PubMed CID80826
SCHEMBL ID295816
MeSH IDM0109502

Synonyms (42)

Synonym
n-[4-(aminomethyl)phenyl]-n,n-dimethylamine
EN300-13350
4-dimethylaminobenzylamine
19293-58-4
4-(n,n-dimethylamino)benzylamine
para-dimethylaminobenzylamine
EU-0033353
STK503378
4-(aminomethyl)-n,n-dimethylaniline
C90108
AKOS000264243
HMS1648B11
p-dimethylaminobenzylamine
benzenemethanamine, 4-(dimethylamino)-
einecs 229-033-0
nsc 207808
1,4-dichlorocyclohexane; 4-(dimethylamino)-benzylamine
A813619
4-(dimethylamino)benzylamine
[4-(aminomethyl)phenyl]dimethylamine
benzenemethanamine,4-(dimethylamino)-
FT-0637822
FS-1747
4-(aminomethyl)-n,n-dimethylbenzenamine
SCHEMBL295816
PDJZOFLRRJQYBF-UHFFFAOYSA-N
(4-dimethylaminophenyl)methylamine
mfcd00466364
gabapentinenacarbil
W-206422
4-(dimethylamino)-benzylamine
DTXSID30940965
AMY15242
BBL037746
CS-0096267
SB76599
SY069455
Z90122421
[[4-(dimethylamino)phenyl]methyl]amine
S273H97VEA
p-(n,n-dimethylamino)benzylamine
4-(dimethylamino)benzenemethanamine
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (2)

Assay IDTitleYearJournalArticle
AID588519A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities2011Antiviral research, Sep, Volume: 91, Issue:3
High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors.
AID540299A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis2010Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21
Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (12.50)18.7374
1990's2 (25.00)18.2507
2000's3 (37.50)29.6817
2010's2 (25.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.47

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.47 (24.57)
Research Supply Index2.20 (2.92)
Research Growth Index4.66 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.47)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other8 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
hydrogen
Hydrogen: The first chemical element in the periodic table with atomic symbol H, and atomic number 1. Protium (atomic weight 1) is by far the most common hydrogen isotope. Hydrogen also exists as the stable isotope DEUTERIUM (atomic weight 2) and the radioactive isotope TRITIUM (atomic weight 3). Hydrogen forms into a diatomic molecule at room temperature and appears as a highly flammable colorless and odorless gas.. dihydrogen : An elemental molecule consisting of two hydrogens joined by a single bond.		2.0410elemental hydrogen;
elemental molecule;
gas molecular entity		antioxidant;
electron donor;
food packaging gas;
fuel;
human metabolite
dihydroxyphenylalanine
Dihydroxyphenylalanine: A beta-hydroxylated derivative of phenylalanine. The D-form of dihydroxyphenylalanine has less physiologic activity than the L-form and is commonly used experimentally to determine whether the pharmacological effects of LEVODOPA are stereospecific.. dopa : A hydroxyphenylalanine carrying hydroxy substituents at positions 3 and 4 of the benzene ring.		2.4120hydroxyphenylalanine;
non-proteinogenic alpha-amino acid;
tyrosine derivative		human metabolite
putrescine
[no description available]		1.9810alkane-alpha,omega-diamineantioxidant;
fundamental metabolite
hydroxyindoleacetic acid
(5-hydroxyindol-3-yl)acetic acid : A member of the class of indole-3-acetic acids that is indole-3-acetic acid substituted by a hydroxy group at C-5.		210indole-3-acetic acidsdrug metabolite;
human metabolite;
mouse metabolite
clorgyline
Clorgyline: An antidepressive agent and monoamine oxidase inhibitor related to PARGYLINE.. clorgyline : An aromatic ether that is the 2,4-dichlorophenyl ether of 3-aminopropan-1-ol in which the nitrogen is substituted by a methyl group and a prop-1-yn-3-yl group. A monoamine oxidase inhibitor, it was formerly used as an antidepressant.		1.9610aromatic ether;
dichlorobenzene;
terminal acetylenic compound;
tertiary amino compound		antidepressant;
EC 1.4.3.4 (monoamine oxidase) inhibitor
2-phenylpyridine
2-phenylpyridine: structure given in first source		2.0410
5-hydroxyindole
[no description available]		710hydroxyindoleshuman metabolite
osmium
Osmium: A very hard, gray, toxic, and nearly infusible metal element, atomic number 76, atomic weight 190.2, symbol Os.		2.0410iron group element atom;
platinum group metal atom
selegiline
Selegiline: A selective, irreversible inhibitor of Type B monoamine oxidase that is used for the treatment of newly diagnosed patients with PARKINSON DISEASE, and for the treatment of depressive disorders. The compound without isomeric designation is Deprenyl.		1.9610selegiline;
terminal acetylenic compound		geroprotector
6-hydroxydopa
6-hydroxydopa: RN given refers to cpd without isomeric designation		1.9810non-proteinogenic alpha-amino acid
6-hydroxydopa quinone
6-hydroxydopa quinone: structure given in first source; quinoid cofactor of quinoproteins; RN given refers to the 4-hydroxy-3,6-dioxo- tautomer. L-topaquinone : A topaquinone that has S configuration.		2.0310
ConditionIndicatedRelationship StrengthStudiesTrials
Encephalitis, Polio
[description not available]		02.0610
Poliomyelitis
An acute infectious disease of humans, particularly children, caused by any of three serotypes of human poliovirus (POLIOVIRUS). Usually the infection is limited to the gastrointestinal tract and nasopharynx, and is often asymptomatic. The central nervous system, primarily the spinal cord, may be affected, leading to rapidly progressive paralysis, coarse FASCICULATION and hyporeflexia. Motor neurons are primarily affected. Encephalitis may also occur. The virus replicates in the nervous system, and may cause significant neuronal loss, most notably in the spinal cord. A rare related condition, nonpoliovirus poliomyelitis, may result from infections with nonpoliovirus enteroviruses. (From Adams et al., Principles of Neurology, 6th ed, pp764-5)		02.0610