Page last updated: 2024-12-05

4,4'-diaminodibenzyl

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

4,4'-Diaminodibenzyl (DADB) is a diamine compound with the chemical formula C14H16N2. It is a colorless solid that is soluble in organic solvents. DADB is synthesized through the reduction of 4,4'-dinitrodibenzyl, which can be obtained through the nitration of dibenzyl. DADB has been investigated for its potential applications in various fields, including: polymers, pharmaceuticals, and electronics. It has shown promising properties as a curing agent for epoxy resins, a precursor for the synthesis of polyamides, and a component in the development of organic semiconductors. Research into DADB focuses on exploring its reactivity, its ability to form complexes with metal ions, its potential as a building block for functional materials, and its use in the development of new technologies.'

4,4'-diaminodibenzyl: RN given refers to parent cpd [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID12138
CHEMBL ID1704183
SCHEMBL ID187043
MeSH IDM0097228

Synonyms (63)

Synonym
smr000476340
MLS001180989
4,4'-ethylenebis(aniline)
aniline, p,p'-ethylenedi-
brn 0394999
nsc 44062
nsc 60033
nsc 580
einecs 210-716-7
aniline, 4,4'-ethylenedi-
alpha,alpha'-bi-p-toluidine
4,4'-diaminodibenzyl
ccris 1004
BB 0221264
benzenamine, 4,4'-(1,2-ethanediyl)bis-
nsc-44062
nsc44062
nsc60033
nsc-60033
4-[2-(4-aminophenyl)ethyl]phenylamine
AH-034/32835045
OPREA1_504832
CBDIVE_013839
alpha, alpha-bi-p-toluidine
4-[2-(4-aminophenyl)ethyl]aniline
621-95-4
nsc580
.alpha.,.alpha.'-bi-p-toluidine
nsc-580
aniline,4'-ethylenedi-
1,2-bis(4-aminophenyl)ethane
4,4'-diaminobibenzyl
1,2-bis(p-aminophenyl)ethane
benzenamine,4'-(1,2-ethanediyl)bis-
4,4'-ethylenedianiline
4,4'-ethylenedianiline, technical, >=95% (nt)
STL089722
4,4'-ethane-1,2-diyldianiline
4,4'-diamino-1,2-diphenylethane
E0346
AKOS000120248
4-(4-aminophenethyl)benzenamine
A8596
4,4 inverted exclamation marka-ethylenedianiline
HMS2804F06
ec 210-716-7
4-13-00-00401 (beilstein handbook reference)
FT-0617109
SCHEMBL187043
DTXSID3060742
W-105034
CHEMBL1704183
AC-16755
4-[2-(4-aminophenyl)ethyl]phenylamine #
4,4-ethylenedianiline
mfcd00007923
AS-60549
a,a'-bi-p-toluidine
4,4'-(ethane-1,2-diyl)dianiline
F16584
EN300-18238
CS-0089167
Z256707848
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (3)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
USP1 protein, partialHomo sapiens (human)Potency11.22020.031637.5844354.8130AID743255
DNA polymerase iota isoform a (long)Homo sapiens (human)Potency89.12510.050127.073689.1251AID588590
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Other Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
FAD-linked sulfhydryl oxidase ALRHomo sapiens (human)AC501.90600.00503.212622.7870AID493248
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (11)

Assay IDTitleYearJournalArticle
AID1745845Primary qHTS for Inhibitors of ATXN expression
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID651635Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (14.29)18.2507
2000's2 (28.57)29.6817
2010's3 (42.86)24.3611
2020's1 (14.29)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.59

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.59 (24.57)
Research Supply Index2.20 (2.92)
Research Growth Index4.78 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.59)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other8 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]