Ribonuclease pancreatic

A ribonuclease pancreatic that is encoded in the genome of human. [PRO:DNx, UniProtKB:P07998]

EC 4.6.1.18;
HP-RNase;
RIB-1;
RNase UpI-1;
Ribonuclease 1;
RNase 1;
Ribonuclease A;
RNase A

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
3'-cmp	Homo sapiens (human)	IC50	312.0000	1	1
3'-cmp	Homo sapiens (human)	Ki	103.0000	1	1

This protein enables 5 target(s):

Target	Category	Definition
nucleic acid binding	molecular function	Binding to a nucleic acid. [GOC:jl]
ribonuclease A activity	molecular function	Catalysis of the endonucleolytic cleavage of RNA to 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending in C-P or U-P with 2',3'-cyclic phosphate intermediates. [EC:4.6.1.18]
RNA nuclease activity	molecular function	Catalysis of the hydrolysis of phosphodiester bonds in chains of RNA. [GOC:mah, ISBN:0198547684]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
lyase activity	molecular function	Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. [ISBN:0198547684]

This protein is located in 1 target(s):

Target	Category	Definition
extracellular exosome	cellular component	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]

This protein is involved in 1 target(s):

Target	Category	Definition
defense response to Gram-positive bacterium	biological process	Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism. [GOC:ai]