Page last updated: 2024-08-08 00:33:49

Ribonuclease pancreatic

A ribonuclease pancreatic that is encoded in the genome of human. [PRO:DNx, UniProtKB:P07998]

Synonyms

EC 4.6.1.18;
HP-RNase;
RIB-1;
RNase UpI-1;
Ribonuclease 1;
RNase 1;
Ribonuclease A;
RNase A

Research

Bioassay Publications (1)

TimeframeStudies on this Protein(%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (100.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Compounds (1)

Drugs with Inhibition Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
3'-cmpHomo sapiens (human)IC50312.000011
3'-cmpHomo sapiens (human)Ki103.000011

Enables

This protein enables 5 target(s):

TargetCategoryDefinition
nucleic acid bindingmolecular functionBinding to a nucleic acid. [GOC:jl]
ribonuclease A activitymolecular functionCatalysis of the endonucleolytic cleavage of RNA to 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending in C-P or U-P with 2',3'-cyclic phosphate intermediates. [EC:4.6.1.18]
RNA nuclease activitymolecular functionCatalysis of the hydrolysis of phosphodiester bonds in chains of RNA. [GOC:mah, ISBN:0198547684]
protein bindingmolecular functionBinding to a protein. [GOC:go_curators]
lyase activitymolecular functionCatalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. [ISBN:0198547684]

Located In

This protein is located in 1 target(s):

TargetCategoryDefinition
extracellular exosomecellular componentA vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]

Involved In

This protein is involved in 1 target(s):

TargetCategoryDefinition
defense response to Gram-positive bacteriumbiological processReactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism. [GOC:ai]