A ribonuclease pancreatic that is encoded in the genome of human. [PRO:DNx, UniProtKB:P07998]
EC 4.6.1.18;
HP-RNase;
RIB-1;
RNase UpI-1;
Ribonuclease 1;
RNase 1;
Ribonuclease A;
RNase A
Timeframe | Studies on this Protein(%) | All Drugs % |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 1 (100.00) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
---|---|---|---|---|---|
3'-cmp | Homo sapiens (human) | IC50 | 312.0000 | 1 | 1 |
3'-cmp | Homo sapiens (human) | Ki | 103.0000 | 1 | 1 |
This protein enables 5 target(s):
Target | Category | Definition |
---|---|---|
nucleic acid binding | molecular function | Binding to a nucleic acid. [GOC:jl] |
ribonuclease A activity | molecular function | Catalysis of the endonucleolytic cleavage of RNA to 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending in C-P or U-P with 2',3'-cyclic phosphate intermediates. [EC:4.6.1.18] |
RNA nuclease activity | molecular function | Catalysis of the hydrolysis of phosphodiester bonds in chains of RNA. [GOC:mah, ISBN:0198547684] |
protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
lyase activity | molecular function | Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. [ISBN:0198547684] |
This protein is located in 1 target(s):
Target | Category | Definition |
---|---|---|
extracellular exosome | cellular component | A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] |
This protein is involved in 1 target(s):
Target | Category | Definition |
---|---|---|
defense response to Gram-positive bacterium | biological process | Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism. [GOC:ai] |