Page last updated: 2024-12-05
1,1,1-trifluoroethane
1,1,1-trifluoroethane, also known as HFC-143a, is a colorless, odorless, non-flammable gas. It is primarily synthesized through the hydrochlorofluorocarbon (HCFC) process, where HCFC-22 (chlorodifluoromethane) is reacted with hydrogen in the presence of a catalyst. 1,1,1-trifluoroethane is used as a propellant in aerosols, a refrigerant in air conditioning systems, and as a blowing agent in the production of foams. Its high thermal stability and low ozone depletion potential (ODP) make it a suitable alternative to chlorofluorocarbons (CFCs) and hydrochlorofluorocarbons (HCFCs). 1,1,1-trifluoroethane has been studied extensively due to its potential environmental impact as a greenhouse gas, with a global warming potential (GWP) of 4,660 over a 100-year timeframe. This has led to research on alternative refrigerants with lower GWPs. In addition, its potential effects on human health, particularly respiratory irritation, have been investigated. Despite its potential drawbacks, 1,1,1-trifluoroethane remains a widely used compound in various applications.'
Cross-References
| ID Source | ID |
|---|
| PubMed CID | 9868 |
| MeSH ID | M0273539 |
Synonyms (41)
| Synonym |
|---|
| methylfluoroform |
| ethane, 1,1,1-trifluoro- |
| fluorocarbon fc143a |
| r 143 |
| r 143a |
| fc143a |
| brn 1731552 |
| 1,1,1-trifluoroethane |
| 1,1,1-trifluoroform |
| ccris 7696 |
| einecs 206-996-5 |
| hfc-143a |
| 4-01-00-00122 (beilstein handbook reference) |
| ec 206-996-5 |
| 84581c5prn , |
| hsdb 8301 |
| unii-84581c5prn |
| 420-46-2 |
| 1,1,1-tris(fluoranyl)ethane |
| A825732 |
| AKOS006228174 |
| 1,1,1-trifluoroethane, compressed or refrigerant gas r 143a [un2035] [flammable gas] |
| r143 |
| 1,1,1-trifluoroethane, compressed or refrigerant gas r 143a |
| einecs 248-764-6 |
| un2035 |
| r143 [un2035] [flammable gas] |
| 27987-06-0 |
| trifluoroethane |
| FT-0605952 |
| ch3cf3 |
| fc 143a |
| freon 143a |
| DTXSID9042047 |
| mfcd00013575 |
| r143a |
| Q161267 |
| 1,1,1-trifluoroethane (fc-143a) |
| 1,1,1-trifluoro-ethane |
| 11,1,1-trifluoroethane |
| 1,1,1-trifluoroethane 100 microg/ml in methanol |
Research Excerpts
Dosage Studied
| Excerpt | Relevance | Reference |
|---|
| "8% for historical control values), the lack of a clear dose-response relationship, and the lack of other developmental effects, these findings were not considered related to HFC-143a exposure." | ( Acute, subchronic, and developmental toxicity and genotoxicity of 1,1,1-trifluoroethane (HFC-143a).
Brock, WJ; Farr, CH; Millischer, RJ; Rusch, GM; Trochimowicz, HJ, 1996) | 0.53 |
Research
Studies (6)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|
| pre-1990 | 1 (16.67) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 3 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Market Indicators
Research Demand Index: 44.75
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.
| Metric | This Compound (vs All) |
|---|
| Research Demand Index | 44.75 (24.57) | | Research Supply Index | 2.30 (2.92) | | Research Growth Index | 4.66 (4.65) | | Search Engine Demand Index | 62.21 (26.88) | | Search Engine Supply Index | 2.00 (0.95) |
| |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|
| Trials | 2 (28.57%) | 5.53% |
| Reviews | 1 (14.29%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 4 (57.14%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |