Page last updated: 2024-12-05

1,1,1-trifluoroethane

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

1,1,1-trifluoroethane, also known as HFC-143a, is a colorless, odorless, non-flammable gas. It is primarily synthesized through the hydrochlorofluorocarbon (HCFC) process, where HCFC-22 (chlorodifluoromethane) is reacted with hydrogen in the presence of a catalyst. 1,1,1-trifluoroethane is used as a propellant in aerosols, a refrigerant in air conditioning systems, and as a blowing agent in the production of foams. Its high thermal stability and low ozone depletion potential (ODP) make it a suitable alternative to chlorofluorocarbons (CFCs) and hydrochlorofluorocarbons (HCFCs). 1,1,1-trifluoroethane has been studied extensively due to its potential environmental impact as a greenhouse gas, with a global warming potential (GWP) of 4,660 over a 100-year timeframe. This has led to research on alternative refrigerants with lower GWPs. In addition, its potential effects on human health, particularly respiratory irritation, have been investigated. Despite its potential drawbacks, 1,1,1-trifluoroethane remains a widely used compound in various applications.'

Cross-References

ID SourceID
PubMed CID9868
MeSH IDM0273539

Synonyms (41)

Synonym
methylfluoroform
ethane, 1,1,1-trifluoro-
fluorocarbon fc143a
r 143
r 143a
fc143a
brn 1731552
1,1,1-trifluoroethane
1,1,1-trifluoroform
ccris 7696
einecs 206-996-5
hfc-143a
4-01-00-00122 (beilstein handbook reference)
ec 206-996-5
84581c5prn ,
hsdb 8301
unii-84581c5prn
420-46-2
1,1,1-tris(fluoranyl)ethane
A825732
AKOS006228174
1,1,1-trifluoroethane, compressed or refrigerant gas r 143a [un2035] [flammable gas]
r143
1,1,1-trifluoroethane, compressed or refrigerant gas r 143a
einecs 248-764-6
un2035
r143 [un2035] [flammable gas]
27987-06-0
trifluoroethane
FT-0605952
ch3cf3
fc 143a
freon 143a
DTXSID9042047
mfcd00013575
r143a
Q161267
1,1,1-trifluoroethane (fc-143a)
1,1,1-trifluoro-ethane
11,1,1-trifluoroethane
1,1,1-trifluoroethane 100 microg/ml in methanol

Research Excerpts

Dosage Studied

ExcerptRelevanceReference
"8% for historical control values), the lack of a clear dose-response relationship, and the lack of other developmental effects, these findings were not considered related to HFC-143a exposure."( Acute, subchronic, and developmental toxicity and genotoxicity of 1,1,1-trifluoroethane (HFC-143a).
Brock, WJ; Farr, CH; Millischer, RJ; Rusch, GM; Trochimowicz, HJ, 1996
)
0.53
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (16.67)18.7374
1990's1 (16.67)18.2507
2000's1 (16.67)29.6817
2010's3 (50.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 44.75

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index44.75 (24.57)
Research Supply Index2.30 (2.92)
Research Growth Index4.66 (4.65)
Search Engine Demand Index62.21 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (44.75)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials2 (28.57%)5.53%
Reviews1 (14.29%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other4 (57.14%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]