Compounds > 1,1,1-trifluoroethane
Page last updated: 2024-12-05

1,1,1-trifluoroethane

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

1,1,1-trifluoroethane, also known as HFC-143a, is a colorless, odorless, non-flammable gas. It is primarily synthesized through the hydrochlorofluorocarbon (HCFC) process, where HCFC-22 (chlorodifluoromethane) is reacted with hydrogen in the presence of a catalyst. 1,1,1-trifluoroethane is used as a propellant in aerosols, a refrigerant in air conditioning systems, and as a blowing agent in the production of foams. Its high thermal stability and low ozone depletion potential (ODP) make it a suitable alternative to chlorofluorocarbons (CFCs) and hydrochlorofluorocarbons (HCFCs). 1,1,1-trifluoroethane has been studied extensively due to its potential environmental impact as a greenhouse gas, with a global warming potential (GWP) of 4,660 over a 100-year timeframe. This has led to research on alternative refrigerants with lower GWPs. In addition, its potential effects on human health, particularly respiratory irritation, have been investigated. Despite its potential drawbacks, 1,1,1-trifluoroethane remains a widely used compound in various applications.'

Cross-References

ID SourceID
PubMed CID9868
MeSH IDM0273539

Synonyms (41)

Synonym
methylfluoroform
ethane, 1,1,1-trifluoro-
fluorocarbon fc143a
r 143
r 143a
fc143a
brn 1731552
1,1,1-trifluoroethane
1,1,1-trifluoroform
ccris 7696
einecs 206-996-5
hfc-143a
4-01-00-00122 (beilstein handbook reference)
ec 206-996-5
84581c5prn ,
hsdb 8301
unii-84581c5prn
420-46-2
1,1,1-tris(fluoranyl)ethane
A825732
AKOS006228174
1,1,1-trifluoroethane, compressed or refrigerant gas r 143a [un2035] [flammable gas]
r143
1,1,1-trifluoroethane, compressed or refrigerant gas r 143a
einecs 248-764-6
un2035
r143 [un2035] [flammable gas]
27987-06-0
trifluoroethane
FT-0605952
ch3cf3
fc 143a
freon 143a
DTXSID9042047
mfcd00013575
r143a
Q161267
1,1,1-trifluoroethane (fc-143a)
1,1,1-trifluoro-ethane
11,1,1-trifluoroethane
1,1,1-trifluoroethane 100 microg/ml in methanol

Research Excerpts

Dosage Studied

ExcerptRelevanceReference
"8% for historical control values), the lack of a clear dose-response relationship, and the lack of other developmental effects, these findings were not considered related to HFC-143a exposure."( Acute, subchronic, and developmental toxicity and genotoxicity of 1,1,1-trifluoroethane (HFC-143a).
Brock, WJ; Farr, CH; Millischer, RJ; Rusch, GM; Trochimowicz, HJ, 1996)		0.53
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (16.67)18.7374
1990's1 (16.67)18.2507
2000's1 (16.67)29.6817
2010's3 (50.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 44.75

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index44.75 (24.57)
Research Supply Index2.30 (2.92)
Research Growth Index4.66 (4.65)
Search Engine Demand Index62.21 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (44.75)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials2 (28.57%)5.53%
Reviews1 (14.29%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other4 (57.14%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
halothane
[no description available]		6.9310haloalkane;
organobromine compound;
organochlorine compound;
organofluorine compound		inhalation anaesthetic
1,1-difluoroethane
[no description available]		2.110
trichlorofluoromethane
trichlorofluoromethane: refrigerant, aerosol propellant; RN given refers to parent cpd; structure. trichlorofluoromethane : A one-carbon compound that is methane in which the hydrogens have been replaced by three chlorine and one fluorine atom.		3.2710chlorofluorocarbon;
halomethane		environmental contaminant;
NMR chemical shift reference compound;
NMR solvent;
refrigerant
dichlorodifluoromethane
dichlorodifluoromethane: refrigerant,aerosol propellant		3.2710
1,1,2-trichloro-1,2,2-trifluoroethane
[no description available]		3.2710chlorofluorocarbon;
haloalkane		NMR solvent;
refrigerant
freon 114
Freon 114: InChIKey: DDMOUSALMHHKOS-UHFFFAOYSA-N		3.2710
2,2-dichloro-1,1,1-trifluoroethane
2,2-dichloro-1,1,1-trifluoroethane: structure given in first source. hydrochlorofluorocarbon : An organochlorine compound derived from methane, ethane or propane that contains atoms of hydrogen, chlorine, fluorine, and carbon only.		3.2710
pentafluoroethane
[no description available]		8.620
1,1,1-trichloro-2,2,2-trifluoroethane
[no description available]		3.2710
norflurane
norflurane: may replace R 12 as air-conditioning refrigerant; structure given in first source		3.8930
1,1-dichloro-1-fluoroethane
[no description available]		3.2710
1,1,1,2-tetrafluoro-2-chloroethane
1,1,1,2-tetrafluoro-2-chloroethane: refrigerant		3.2710
1,1,1,3,3-pentafluoropropane
[no description available]		8.8930
fibrinogen
Fibrinogen: Plasma glycoprotein clotted by thrombin, composed of a dimer of three non-identical pairs of polypeptide chains (alpha, beta, gamma) held together by disulfide bonds. Fibrinogen clotting is a sol-gel change involving complex molecular arrangements: whereas fibrinogen is cleaved by thrombin to form polypeptides A and B, the proteolytic action of other enzymes yields different fibrinogen degradation products.. D-iditol : The D-enantiomer of iditol.		3.4211iditolfungal metabolite
2,3,3,3-tetrafluoropropene
2,3,3,3-tetrafluoropropene: structure in first source		3.2710
ConditionIndicatedRelationship StrengthStudiesTrials
Abnormalities, Drug-Induced
Congenital abnormalities caused by medicinal substances or drugs of abuse given to or taken by the mother, or to which she is inadvertently exposed during the manufacture of such substances. The concept excludes abnormalities resulting from exposure to non-medicinal chemicals in the environment.		01.9910