Page last updated: 2024-12-05

1,1-dichloro-1-fluoroethane

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

1,1-Dichloro-1-fluoroethane (HCFC-141b) is a colorless, odorless gas that is commonly used as a blowing agent in the production of rigid polyurethane foam. It is also used as a refrigerant and solvent. 1,1-Dichloro-1-fluoroethane is a member of the hydrochlorofluorocarbon (HCFC) family, which are ozone-depleting substances. As a result, its production and use have been phased out in many countries under the Montreal Protocol. However, it still has some applications in developing countries. 1,1-Dichloro-1-fluoroethane can be synthesized by reacting 1,1,1-trichloroethane with hydrogen fluoride in the presence of a catalyst. It is a relatively stable compound, but it can decompose in the presence of heat or light. The decomposition products include hydrogen chloride, chlorine, and fluoromethane. 1,1-Dichloro-1-fluoroethane is a potent greenhouse gas, with a global warming potential (GWP) of 1430. This means that it is 1430 times more effective at trapping heat in the atmosphere than carbon dioxide. It is also a toxic substance, and exposure to high concentrations can cause respiratory problems, dizziness, and even death. Research on 1,1-Dichloro-1-fluoroethane is primarily focused on developing alternative blowing agents that are less harmful to the environment. The development of new blowing agents is important because they are used in a wide variety of products, including refrigerators, freezers, and insulation. The goal is to find blowing agents that have a low GWP and are non-toxic. In addition, there is ongoing research on the potential for 1,1-Dichloro-1-fluoroethane to be used as a feedstock for the production of other chemicals. This is because it contains both chlorine and fluorine atoms, which are valuable in the chemical industry.'

Cross-References

ID SourceID
PubMed CID15586
SCHEMBL ID27944
MeSH IDM0186909

Synonyms (42)

Synonym
ec 404-080-1
o1a3asy5pw ,
4-01-00-00134 (beilstein handbook reference)
unii-o1a3asy5pw
1717-00-6
freon-141
isotron 141b
refrigerant 141b
cfc-141
hcfc-141b
hcfc 141b
ccris 7208
dichlorofluoroethane
r 141b
brn 1731585
cfc 141b
hsdb 6757
solkane 141b
1,1-dichloro-1-fluoroethane
ethane, 1,1-dichloro-1-fluoro-
inchi=1/c2h3cl2f/c1-2(3,4)5/h1h3
frchksnazzfgca-uhfffaoysa-
1,1-dichloro-1-fluoro-ethane
A811341
r-141b
1-fluoro-1,1-dichloroethane
D2139
AKOS006229792
FT-0606096
dichloro-1-fluoroethane, 1,1-
rc-14
cfc-141b
refrigerant-141b
1,1-dichloro-1-fluoroethane [hsdb]
SCHEMBL27944
genetron 141b
freon 141b
DTXSID2020422
mfcd00042461
1,1-dichloro-1-fluoroethane 100 microg/ml in methanol
Q385448
1,1-dichloro-1-fluoroethane 100 amicrog/ml in methanol

Research Excerpts

Toxicity

ExcerptReferenceRelevance
" Skin application of HCFC-141b to rabbits at 2000 mg/kg body weight produced no adverse effects."( Acute and subchronic toxicity of 1,1-dichloro-1-fluoroethane (HCFC-141b).
Brock, WJ; Farr, C; Kawano, T; Millischer, RJ; Rusch, GM; Trochimowicz, HJ, 1995
)
0.57
" Also, no other toxic effects would be anticipated."( Safety assessment of HCFC-141b: use as a blowing agent for insulation in building construction and refrigeration.
Boberg, RE; Machado, RJ; Turnbull, D, 1994
)
0.29

Pharmacokinetics

ExcerptReferenceRelevance
"A physiologically based pharmacokinetic model was used to determine the in vivo metabolic constants of the candidate chlorofluorocarbon replacement 1,1-dichloro-1-fluoroethane (HCFC-141b)."( Gas-uptake pharmacokinetics and biotransformation of 1,1-dichloro-1-fluoroethane (HCFC-141b).
Anders, MW; Loizou, GD,
)
0.58
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (24)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's11 (45.83)18.2507
2000's10 (41.67)29.6817
2010's3 (12.50)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 29.32

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index29.32 (24.57)
Research Supply Index3.33 (2.92)
Research Growth Index4.29 (4.65)
Search Engine Demand Index36.71 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (29.32)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews4 (14.81%)6.00%
Case Studies1 (3.70%)4.05%
Observational0 (0.00%)0.25%
Other22 (81.48%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]