Page last updated: 2024-12-05

1,1,1-trichloro-2,2,2-trifluoroethane

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

1,1,1-trichloro-2,2,2-trifluoroethane, also known as **Freon 113**, is a chlorofluorocarbon (CFC) that was once widely used as a refrigerant, solvent, and propellant.

**Here's why it's important for research:**

* **Historical Significance:** Freon 113 was a major contributor to ozone depletion in the atmosphere. Its study and eventual phasing out played a crucial role in understanding the dangers of CFCs and led to the development of international agreements like the Montreal Protocol.
* **Environmental Chemistry Research:** Freon 113 is a valuable model compound for research on the atmospheric chemistry of CFCs, including:
* **Ozone depletion:** Studying its breakdown in the stratosphere helped scientists understand how CFCs destroy the ozone layer.
* **Atmospheric transport and persistence:** Research on Freon 113's distribution and lifespan in the atmosphere provided valuable insights into the fate of other persistent organic pollutants.
* **Toxicology and Health Effects:** Freon 113 has been studied for its potential health effects, including its impacts on the respiratory system and liver. This research is crucial for understanding the risks associated with exposure to CFCs.
* **Material Science:** Freon 113 has been used as a solvent in a variety of industrial processes, including the production of polymers and electronics. Research into its properties and applications continues to be relevant.

**However, due to its detrimental impact on the ozone layer, Freon 113 is now banned in most countries. Its production and use are heavily restricted.**

**Current Research:**

While the primary use of Freon 113 is now largely historical, research continues in areas like:

* **Atmospheric monitoring:** Scientists are tracking the remaining amounts of Freon 113 in the atmosphere to understand its long-term fate and assess the effectiveness of the Montreal Protocol.
* **Developing alternative solvents:** Research is ongoing to find environmentally friendly replacements for Freon 113 in industrial processes.

In summary, Freon 113, despite its past use as a harmful chemical, remains relevant for research due to its historical significance, role in environmental chemistry, and ongoing studies into its long-term impact.

Cross-References

ID SourceID
PubMed CID9635
SCHEMBL ID63592
MeSH IDM0047666

Synonyms (47)

Synonym
AKOS015848819
354-58-5
ethane, 1,1,1-trichloro-2,2,2-trifluoro-
1,1,1-trichloro-2,2,2-trifluoroethane
inchi=1/c2cl3f3/c3-1(4,5)2(6,7)
trichlorotrifluoroethane
freon ft
brn 1699455
hsdb 6501
1,1,1-trifluorotrichloroethane
1,1,1-trichlorotrifluoroethane
einecs 206-564-6
f 113a
cfc 113a
t-wd602
fc 113a
precision cleaning agent
NCGC00248515-01
dtxcid307148
tox21_200079
cas-354-58-5
dtxsid5027148 ,
NCGC00257633-01
T1032 ,
einecs 247-758-0
cfc-113a
ec 206-564-6
unii-07h0r79ho0
07h0r79ho0 ,
FT-0605935
freon-ft
r-113a
1,1,1-trichloro-2,2,2-trifluoroethane [hsdb]
freon-113a
freon 113a
SCHEMBL63592
cf3ccl3
1,1,1-trifluoro-2,2,2-trichloroethane
1,1,1,-trichloro-2,2,2-trifluoroethane
1,1,1-trichloro-2,2,2-trifluoro-ethane
2,2,2-trichloro-1,1,1-trifluoro-ethane
1,1,1-trichlorotrifluoroethane, 99%
mfcd00000797
1,1,1-trichlorotrifluoroethane 10 microg/ml in methanol
Q15927952
E77595
AS-75494
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (21)

TimeframeStudies, This Drug (%)All Drugs %
pre-199010 (47.62)18.7374
1990's6 (28.57)18.2507
2000's1 (4.76)29.6817
2010's4 (19.05)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 37.53

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index37.53 (24.57)
Research Supply Index3.26 (2.92)
Research Growth Index4.95 (4.65)
Search Engine Demand Index48.45 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (37.53)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews3 (12.00%)6.00%
Case Studies4 (16.00%)4.05%
Observational0 (0.00%)0.25%
Other18 (72.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]