1,1,1-trichloro-2,2,2-trifluoroethane

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

1,1,1-trichloro-2,2,2-trifluoroethane, also known as **Freon 113**, is a chlorofluorocarbon (CFC) that was once widely used as a refrigerant, solvent, and propellant.

**Here's why it's important for research:**

* **Historical Significance:** Freon 113 was a major contributor to ozone depletion in the atmosphere. Its study and eventual phasing out played a crucial role in understanding the dangers of CFCs and led to the development of international agreements like the Montreal Protocol.
* **Environmental Chemistry Research:** Freon 113 is a valuable model compound for research on the atmospheric chemistry of CFCs, including:
* **Ozone depletion:** Studying its breakdown in the stratosphere helped scientists understand how CFCs destroy the ozone layer.
* **Atmospheric transport and persistence:** Research on Freon 113's distribution and lifespan in the atmosphere provided valuable insights into the fate of other persistent organic pollutants.
* **Toxicology and Health Effects:** Freon 113 has been studied for its potential health effects, including its impacts on the respiratory system and liver. This research is crucial for understanding the risks associated with exposure to CFCs.
* **Material Science:** Freon 113 has been used as a solvent in a variety of industrial processes, including the production of polymers and electronics. Research into its properties and applications continues to be relevant.

**However, due to its detrimental impact on the ozone layer, Freon 113 is now banned in most countries. Its production and use are heavily restricted.**

**Current Research:**

While the primary use of Freon 113 is now largely historical, research continues in areas like:

* **Atmospheric monitoring:** Scientists are tracking the remaining amounts of Freon 113 in the atmosphere to understand its long-term fate and assess the effectiveness of the Montreal Protocol.
* **Developing alternative solvents:** Research is ongoing to find environmentally friendly replacements for Freon 113 in industrial processes.

In summary, Freon 113, despite its past use as a harmful chemical, remains relevant for research due to its historical significance, role in environmental chemistry, and ongoing studies into its long-term impact.

Cross-References

ID Source	ID
PubMed CID	9635
SCHEMBL ID	63592
MeSH ID	M0047666

Synonyms (47)

Synonym
AKOS015848819
354-58-5
ethane, 1,1,1-trichloro-2,2,2-trifluoro-
1,1,1-trichloro-2,2,2-trifluoroethane
inchi=1/c2cl3f3/c3-1(4,5)2(6,7)
trichlorotrifluoroethane
freon ft
brn 1699455
hsdb 6501
1,1,1-trifluorotrichloroethane
1,1,1-trichlorotrifluoroethane
einecs 206-564-6
f 113a
cfc 113a
t-wd602
fc 113a
precision cleaning agent
NCGC00248515-01
dtxcid307148
tox21_200079
cas-354-58-5
dtxsid5027148 ,
NCGC00257633-01
T1032 ,
einecs 247-758-0
cfc-113a
ec 206-564-6
unii-07h0r79ho0
07h0r79ho0 ,
FT-0605935
freon-ft
r-113a
1,1,1-trichloro-2,2,2-trifluoroethane [hsdb]
freon-113a
freon 113a
SCHEMBL63592
cf3ccl3
1,1,1-trifluoro-2,2,2-trichloroethane
1,1,1,-trichloro-2,2,2-trifluoroethane
1,1,1-trichloro-2,2,2-trifluoro-ethane
2,2,2-trichloro-1,1,1-trifluoro-ethane
1,1,1-trichlorotrifluoroethane, 99%
mfcd00000797
1,1,1-trichlorotrifluoroethane 10 microg/ml in methanol
Q15927952
E77595
AS-75494

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (21)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	10 (47.62)	18.7374
1990's	6 (28.57)	18.2507
2000's	1 (4.76)	29.6817
2010's	4 (19.05)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 37.53

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	37.53 (24.57)
Research Supply Index	3.26 (2.92)
Research Growth Index	4.95 (4.65)
Search Engine Demand Index	48.45 (26.88)
Search Engine Supply Index	2.00 (0.95)

This Compound (37.53)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	3 (12.00%)	6.00%
Case Studies	4 (16.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	18 (72.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
methane Methane: The simplest saturated hydrocarbon. It is a colorless, flammable gas, slightly soluble in water. It is one of the chief constituents of natural gas and is formed in the decomposition of organic matter. (Grant & Hackh's Chemical Dictionary, 5th ed). methane : A one-carbon compound in which the carbon is attached by single bonds to four hydrogen atoms. It is a colourless, odourless, non-toxic but flammable gas (b.p. -161degreeC).	1.96	1	alkane; gas molecular entity; mononuclear parent hydride; one-carbon compound	bacterial metabolite; fossil fuel; greenhouse gas
methanol Methanol: A colorless, flammable liquid used in the manufacture of FORMALDEHYDE and ACETIC ACID, in chemical synthesis, antifreeze, and as a solvent. Ingestion of methanol is toxic and may cause blindness.. primary alcohol : A primary alcohol is a compound in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it.. methanol : The primary alcohol that is the simplest aliphatic alcohol, comprising a methyl and an alcohol group.	3.5	2	alkyl alcohol; one-carbon compound; primary alcohol; volatile organic compound	amphiprotic solvent; Escherichia coli metabolite; fuel; human metabolite; mouse metabolite; Mycoplasma genitalium metabolite
1-propanol 1-Propanol: A colorless liquid made by oxidation of aliphatic hydrocarbons that is used as a solvent and chemical intermediate.. propan-1-ol : The parent member of the class of propan-1-ols that is propane in which a hydrogen of one of the methyl groups is replaced by a hydroxy group.	1.95	1	propan-1-ols; short-chain primary fatty alcohol	metabolite; protic solvent
toluene methylbenzene : Any alkylbenzene that is benzene substituted with one or more methyl groups.	1.97	1	methylbenzene; toluenes; volatile organic compound	cholinergic antagonist; fuel additive; neurotoxin; non-polar solvent
atrazine [no description available]	1.98	1	chloro-1,3,5-triazine; diamino-1,3,5-triazine	environmental contaminant; herbicide; xenobiotic
ether Ether: A mobile, very volatile, highly flammable liquid used as an inhalation anesthetic and as a solvent for waxes, fats, oils, perfumes, alkaloids, and gums. It is mildly irritating to skin and mucous membranes.. ether : An organooxygen compound with formula ROR, where R is not hydrogen.. diethyl ether : An ether in which the oxygen atom is linked to two ethyl groups.	1.96	1	ether; volatile organic compound	inhalation anaesthetic; non-polar solvent; refrigerant
chloroform Chloroform: A commonly used laboratory solvent. It was previously used as an anesthetic, but was banned from use in the U.S. due to its suspected carcinogenicity.. chloroform : A one-carbon compound that is methane in which three of the hydrogens are replaced by chlorines.	1.96	1	chloromethanes; one-carbon compound	carcinogenic agent; central nervous system drug; inhalation anaesthetic; non-polar solvent; refrigerant
1,1,1-trichloroethane Trichloroethanes: Chlorinated ethanes which are used extensively as industrial solvents. They have been utilized in numerous home-use products including spot remover preparations and inhalant decongestant sprays. These compounds cause central nervous system and cardiovascular depression and are hepatotoxic. Include 1,1,1- and 1,1,2-isomers.. 1,1,1-trichloroethane : A member of the class of chloroethanes carrying three chloro substituents at position 1.	1.97	1	chloroethanes	polar solvent
methylene chloride Methylene Chloride: A chlorinated hydrocarbon that has been used as an inhalation anesthetic and acts as a narcotic in high concentrations. Its primary use is as a solvent in manufacturing and food technology.. dichloromethane : A member of the class of chloromethanes that is methane in which two of the hydrogens have been replaced by chlorine. A dense, non-flammible colourless liquid at room temperature (b.p. 40degreeC, d = 1.33) which is immiscible with water, it is widely used as a solvent, a paint stripper, and for the removal of caffeine from coffee and tea.	1.96	1	chloromethanes; volatile organic compound	carcinogenic agent; polar aprotic solvent; refrigerant
nitromethane nitromethane: structure. nitromethane : A primary nitroalkane that is methane in which one of the hydrogens is replace by a nitro group. A polar solvent (b.p. 101 degreeC), it is an important starting material in organic synthesis. It is also used as a fuel for rockets and radio-controlled models.	1.96	1	primary nitroalkane; volatile organic compound	EC 4.3.1.3 (histidine ammonia-lyase) inhibitor; explosive; NMR chemical shift reference compound; polar aprotic solvent
trichlorofluoromethane trichlorofluoromethane: refrigerant, aerosol propellant; RN given refers to parent cpd; structure. trichlorofluoromethane : A one-carbon compound that is methane in which the hydrogens have been replaced by three chlorine and one fluorine atom.	3.27	1	chlorofluorocarbon; halomethane	environmental contaminant; NMR chemical shift reference compound; NMR solvent; refrigerant
dichlorodifluoromethane dichlorodifluoromethane: refrigerant,aerosol propellant	3.52	2
1,1,2-trichloro-1,2,2-trifluoroethane [no description available]	3.27	1	chlorofluorocarbon; haloalkane	NMR solvent; refrigerant
freon 114 Freon 114: InChIKey: DDMOUSALMHHKOS-UHFFFAOYSA-N	3.27	1
trichloroethylene Trichloroethylene: A highly volatile inhalation anesthetic used mainly in short surgical procedures where light anesthesia with good analgesia is required. It is also used as an industrial solvent. Prolonged exposure to high concentrations of the vapor can lead to cardiotoxicity and neurological impairment.. triol : A chemical compound containing three hydroxy groups.	2.41	2	chloroethenes	inhalation anaesthetic; mouse metabolite
3-xylene m-xylene : A xylene carrying methyl groups at positions 1 and 3.	1.97	1	xylene
diethylhexyl phthalate Diethylhexyl Phthalate: An ester of phthalic acid. It appears as a light-colored, odorless liquid and is used as a plasticizer for many resins and elastomers.. bis(2-ethylhexyl) phthalate : A phthalate ester that is the bis(2-ethylhexyl) ester of benzene-1,2-dicarboxylic acid.	1.98	1	diester; phthalate ester	androstane receptor agonist; apoptosis inhibitor; plasticiser
ethyl acetate ethyl acetate : The acetate ester formed between acetic acid and ethanol.	1.96	1	acetate ester; ethyl ester; volatile organic compound	EC 3.4.19.3 (pyroglutamyl-peptidase I) inhibitor; metabolite; polar aprotic solvent; Saccharomyces cerevisiae metabolite
2,2-dichloro-1,1,1-trifluoroethane 2,2-dichloro-1,1,1-trifluoroethane: structure given in first source. hydrochlorofluorocarbon : An organochlorine compound derived from methane, ethane or propane that contains atoms of hydrogen, chlorine, fluorine, and carbon only.	3.27	1
pentafluoroethane [no description available]	3.27	1
1,1,1-trifluoroethane [no description available]	3.27	1
norflurane norflurane: may replace R 12 as air-conditioning refrigerant; structure given in first source	3.27	1
methyl tert-butyl ether methyl tert-butyl ether: used to dissolve gallstones; gasoline additive. methyl tert-butyl ether : An ether having methyl and tert-butyl as the two alkyl components.	1.96	1	ether	fuel additive; metabolite; non-polar solvent
1,1-dichloro-1-fluoroethane [no description available]	3.27	1
1,1,1,2-tetrafluoro-2-chloroethane 1,1,1,2-tetrafluoro-2-chloroethane: refrigerant	3.27	1
fluorides [no description available]	1.97	1	halide anion; monoatomic fluorine
phenyl acetate phenyl acetate: The ester formed between phenol and acetic acid. Don't confuse with phenylacetic acid derivatives listed under PHENYLACETATES.. phenyl acetate : An acetate ester obtained by the formal condensation of phenol with acetic acid.	1.96	1	benzenes; phenyl acetates
tetrachloroethylene Tetrachloroethylene: A chlorinated hydrocarbon used as an industrial solvent and cooling liquid in electrical transformers. It is a potential carcinogen.	2.41	2	chlorocarbon; chloroethenes	nephrotoxic agent
1,1,1,3,3-pentafluoropropane [no description available]	3.27	1
hydroxyl radical Hydroxyl Radical: The univalent radical OH. Hydroxyl radical is a potent oxidizing agent.	1.98	1	oxygen hydride; oxygen radical; reactive oxygen species
2,3,3,3-tetrafluoropropene 2,3,3,3-tetrafluoropropene: structure in first source	3.27	1
silicon Silicon: A trace element that constitutes about 27.6% of the earth's crust in the form of SILICON DIOXIDE. It does not occur free in nature. Silicon has the atomic symbol Si, atomic number 14, and atomic weight [28.084; 28.086].	3.19	1	carbon group element atom; metalloid atom; nonmetal atom
phosphatidylcholines Phosphatidylcholines: Derivatives of PHOSPHATIDIC ACIDS in which the phosphoric acid is bound in ester linkage to a CHOLINE moiety.	1.97	1	1,2-diacyl-sn-glycero-3-phosphocholine

Condition	Relationship Strength	Studies
Diseases, Occupational [description not available]	2.88	4
Atherosclerotic Parkinsonism [description not available]	1.96	1
Parkinson Disease, Secondary Conditions which feature clinical manifestations resembling primary Parkinson disease that are caused by a known or suspected condition. Examples include parkinsonism caused by vascular injury, drugs, trauma, toxin exposure, neoplasms, infections and degenerative or hereditary conditions. Clinical features may include bradykinesia, rigidity, parkinsonian gait, and masked facies. In general, tremor is less prominent in secondary parkinsonism than in the primary form. (From Joynt, Clinical Neurology, 1998, Ch38, pp39-42)	1.96	1
Arrhythmia [description not available]	1.98	1
Arrhythmias, Cardiac Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by the abnormalities in HEART RATE, disorders of electrical impulse generation, or impulse conduction.	1.98	1
Body Weight The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.	1.97	1
Adenoma, Basal Cell [description not available]	1.97	1
Island Cell Tumor [description not available]	1.97	1
Adenoma A benign epithelial tumor with a glandular organization.	1.97	1
Adenoma, Islet Cell A benign tumor of the pancreatic ISLET CELLS. Usually it involves the INSULIN-producing PANCREATIC BETA CELLS, as in INSULINOMA, resulting in HYPERINSULINISM.	1.97	1
Clerambault Syndrome [description not available]	1.97	1
Hyperlipemia [description not available]	1.96	1
Hyperlipidemias Conditions with excess LIPIDS in the blood.	1.96	1
Asystole [description not available]	1.96	1
Heart Arrest Cessation of heart beat or MYOCARDIAL CONTRACTION. If it is treated within a few minutes, heart arrest can be reversed in most cases to normal cardiac rhythm and effective circulation.	1.96	1

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