nicotinamide riboside catabolic process

Definition

Target type: biologicalprocess

The chemical reactions and pathways resulting in the breakdown of nicotinamide riboside, the product of the formation of a glycosidic bond between ribose and nicotinamide. [ISBN:0198506732]

Nicotinamide riboside (NR) catabolism is a metabolic pathway that breaks down NR into nicotinamide (NAM), a precursor for the essential coenzyme NAD+. This process is crucial for maintaining NAD+ levels, which are essential for various cellular processes, including energy production, DNA repair, and signaling.

NR catabolism is initiated by the enzyme nicotinamide riboside kinase (NRK), which phosphorylates NR to nicotinamide mononucleotide (NMN). NMN is then further metabolized to NAM by the enzyme nicotinamide mononucleotide adenylyltransferase (NMNAT).

The breakdown of NR to NAM is tightly regulated. When NAD+ levels are low, NRK activity is increased, leading to increased NR catabolism and NAD+ synthesis. Conversely, when NAD+ levels are high, NRK activity is inhibited, reducing NR catabolism.

NR catabolism can also be influenced by other factors, such as dietary intake of NR, age, and disease state. For example, dietary supplementation with NR has been shown to increase NAD+ levels and improve metabolic health.

In summary, NR catabolism is an essential process for maintaining NAD+ levels, which are crucial for various cellular functions. The process is tightly regulated and influenced by various factors, including dietary intake, age, and disease state.'
"

Proteins (2)

Compounds (27)