Assay ID | Title | Year | Journal | Article |
AID1543981 | Binding affinity to recombinant Helicobacter pylori MTAN expressed in Escherichia coli BL21(DE3) assessed as equilibrium dissociation constant using MTA as substrate measured after 2 hrs in presence of xanthine oxidase | 2019 | Journal of medicinal chemistry, 04-11, Volume: 62, Issue:7
| Selective Inhibitors of Helicobacter pylori Methylthioadenosine Nucleosidase and Human Methylthioadenosine Phosphorylase. |
AID507713 | Inhibition of MTAP in human FaDu cells by ESI-MS analysis | 2009 | Nature chemical biology, Apr, Volume: 5, Issue:4
| Transition state analogs of 5'-methylthioadenosine nucleosidase disrupt quorum sensing. |
AID507720 | Inhibition of Vibrio cholerae N16961 MTAN-mediated autoinducer-1 production assessed as inhibition of light induction in quorum-sensing Vibrio harveyi BB170 by luminescence induction assay | 2009 | Nature chemical biology, Apr, Volume: 5, Issue:4
| Transition state analogs of 5'-methylthioadenosine nucleosidase disrupt quorum sensing. |
AID677884 | Inhibition of Neisseria meningitidis MTAN assessed as reduction in methylthioadenosine phosphorolysis/hydrolysi | 2012 | Bioorganic & medicinal chemistry, Sep-01, Volume: 20, Issue:17
| Transition state analogue inhibitors of human methylthioadenosine phosphorylase and bacterial methylthioadenosine/S-adenosylhomocysteine nucleosidase incorporating acyclic ribooxacarbenium ion mimics. |
AID677808 | Inhibition of human MTAP assessed as reduction in methylthioadenosine phosphorolysis/hydrolysis | 2012 | Bioorganic & medicinal chemistry, Sep-01, Volume: 20, Issue:17
| Transition state analogue inhibitors of human methylthioadenosine phosphorylase and bacterial methylthioadenosine/S-adenosylhomocysteine nucleosidase incorporating acyclic ribooxacarbenium ion mimics. |
AID317483 | Inhibition of Escherichia coli MTAN | 2008 | Journal of medicinal chemistry, Feb-28, Volume: 51, Issue:4
| Azetidine based transition state analogue inhibitors of N-ribosyl hydrolases and phosphorylases. |
AID1241015 | Inhibition of recombinant Escherichia coli MTAN expressed in Escherichia coli BL-21 DE3 using methylthioadenosine as substrate by xanthine oxidase coupling enzyme assay | 2015 | Bioorganic & medicinal chemistry, Sep-01, Volume: 23, Issue:17
| Tight binding enantiomers of pre-clinical drug candidates. |
AID507723 | Antibacterial activity MTAN-deficient Escherichia coli assessed as induction of growth deffect at 0.5 uM after 16 hrs | 2009 | Nature chemical biology, Apr, Volume: 5, Issue:4
| Transition state analogs of 5'-methylthioadenosine nucleosidase disrupt quorum sensing. |
AID1241014 | Inhibition of human MTAP using methylthioadenosine as substrate assessed as inhibition constant for slow onset inhibition of enzyme-inhibitor complex by xanthine oxidase coupling enzyme assay | 2015 | Bioorganic & medicinal chemistry, Sep-01, Volume: 23, Issue:17
| Tight binding enantiomers of pre-clinical drug candidates. |
AID1241017 | Binding affinity to recombinant Escherichia coli MTAN expressed in Escherichia coli BL-21 DE3 at 225 uM by isothermal titration calorimetry | 2015 | Bioorganic & medicinal chemistry, Sep-01, Volume: 23, Issue:17
| Tight binding enantiomers of pre-clinical drug candidates. |
AID507721 | Inhibition of Vibrio cholerae N16961 MTAN-mediated autoinducer-2 production assessed as inhibition of light induction in quorum-sensing Vibrio harveyi BB120 at 1 uM by luminescence induction assay | 2009 | Nature chemical biology, Apr, Volume: 5, Issue:4
| Transition state analogs of 5'-methylthioadenosine nucleosidase disrupt quorum sensing. |
AID507740 | Binding affinity to His-tagged Vibrio cholerae recombinant MTAN expressed in Escherichia coli B21 | 2009 | Nature chemical biology, Apr, Volume: 5, Issue:4
| Transition state analogs of 5'-methylthioadenosine nucleosidase disrupt quorum sensing. |
AID507717 | Inhibition of Vibrio cholera N16961 MTAN -mediated adenine production by reverse-phase HPLC | 2009 | Nature chemical biology, Apr, Volume: 5, Issue:4
| Transition state analogs of 5'-methylthioadenosine nucleosidase disrupt quorum sensing. |
AID317484 | Inhibition of Streptococcus pneumoniae MTAN | 2008 | Journal of medicinal chemistry, Feb-28, Volume: 51, Issue:4
| Azetidine based transition state analogue inhibitors of N-ribosyl hydrolases and phosphorylases. |
AID507722 | Antibacterial activity Escherichia coli O157:H7 EDL933 assessed as induction of growth deffect at 0.5 uM after 16 hrs | 2009 | Nature chemical biology, Apr, Volume: 5, Issue:4
| Transition state analogs of 5'-methylthioadenosine nucleosidase disrupt quorum sensing. |
AID1241013 | Inhibition of human MTAP using methylthioadenosine as substrate by xanthine oxidase coupling enzyme assay | 2015 | Bioorganic & medicinal chemistry, Sep-01, Volume: 23, Issue:17
| Tight binding enantiomers of pre-clinical drug candidates. |
AID507724 | Inhibition of Escherichia coli O157:H7 EDL933 MTAN-mediated autoinducer-2 production assessed as inhibition of light induction in quorum-sensing Vibrio harveyi BB120 by luminescence induction assay | 2009 | Nature chemical biology, Apr, Volume: 5, Issue:4
| Transition state analogs of 5'-methylthioadenosine nucleosidase disrupt quorum sensing. |
AID507714 | Inhibition of MTAP in human CRL2522 cells by by ESI-MS analysis | 2009 | Nature chemical biology, Apr, Volume: 5, Issue:4
| Transition state analogs of 5'-methylthioadenosine nucleosidase disrupt quorum sensing. |
AID507718 | Inhibition of Vibrio cholerae N16961 MTAN-mediated autoinducer-1 production assessed as inhibition of light induction in quorum-sensing Vibrio harveyi BB120 by luminescence induction assay | 2009 | Nature chemical biology, Apr, Volume: 5, Issue:4
| Transition state analogs of 5'-methylthioadenosine nucleosidase disrupt quorum sensing. |
AID507710 | Inhibition of Vibrio cholerae N16961 MTAN-mediated autoinducer-1 production assessed as inhibition of light induction in quorum-sensing Vibrio harveyi BB120 at 1 uM by luminescence induction assay | 2009 | Nature chemical biology, Apr, Volume: 5, Issue:4
| Transition state analogs of 5'-methylthioadenosine nucleosidase disrupt quorum sensing. |
AID507719 | Inhibition of Vibrio cholerae N16961 MTAN-mediated autoinducer-2 production assessed as inhibition of light induction in quorum-sensing Vibrio harveyi BB120 by luminescence induction assay | 2009 | Nature chemical biology, Apr, Volume: 5, Issue:4
| Transition state analogs of 5'-methylthioadenosine nucleosidase disrupt quorum sensing. |
AID507711 | Inhibition of Escherichia coli MTAN | 2009 | Nature chemical biology, Apr, Volume: 5, Issue:4
| Transition state analogs of 5'-methylthioadenosine nucleosidase disrupt quorum sensing. |
AID677883 | Inhibition of Escherichia coli MTAN assessed as reduction in methylthioadenosine phosphorolysis/hydrolysis | 2012 | Bioorganic & medicinal chemistry, Sep-01, Volume: 20, Issue:17
| Transition state analogue inhibitors of human methylthioadenosine phosphorylase and bacterial methylthioadenosine/S-adenosylhomocysteine nucleosidase incorporating acyclic ribooxacarbenium ion mimics. |
AID507716 | Antimicrobial activity against Vibrio cholerae N16961 assessed as effect on cell growth up to 1 uM | 2009 | Nature chemical biology, Apr, Volume: 5, Issue:4
| Transition state analogs of 5'-methylthioadenosine nucleosidase disrupt quorum sensing. |
AID1241016 | Inhibition of recombinant Escherichia coli MTAN expressed in Escherichia coli BL-21 DE3 using methylthioadenosine as substrate assessed as inhibition constant for slow onset inhibition of enzyme-inhibitor complex by xanthine oxidase coupling enzyme assay | 2015 | Bioorganic & medicinal chemistry, Sep-01, Volume: 23, Issue:17
| Tight binding enantiomers of pre-clinical drug candidates. |
AID317482 | Inhibition of human MTAP | 2008 | Journal of medicinal chemistry, Feb-28, Volume: 51, Issue:4
| Azetidine based transition state analogue inhibitors of N-ribosyl hydrolases and phosphorylases. |
AID507715 | Inhibition of His-tagged Vibrio cholerae recombinant MTAN expressed in Escherichia coli B21 by spectrophotometry | 2009 | Nature chemical biology, Apr, Volume: 5, Issue:4
| Transition state analogs of 5'-methylthioadenosine nucleosidase disrupt quorum sensing. |
AID1799419 | Enzyme Activity Assay from Article 10.1021/cb700166z: \\Picomolar inhibitors as transition-state probes of 5'-methylthioadenosine nucleosidases.\\ | 2007 | ACS chemical biology, Nov-20, Volume: 2, Issue:11
| Picomolar inhibitors as transition-state probes of 5'-methylthioadenosine nucleosidases. |
AID1799400 | MTAN Inhibition Assay from Article 10.1038/nchembio.153: \\Transition state analogs of 5'-methylthioadenosine nucleosidase disrupt quorum sensing.\\ | 2009 | Nature chemical biology, Apr, Volume: 5, Issue:4
| Transition state analogs of 5'-methylthioadenosine nucleosidase disrupt quorum sensing. |
AID1798157 | MTAP/MTAN Inhibition Assay from Article 10.1021/jm701265n: \\Azetidine based transition state analogue inhibitors of N-ribosyl hydrolases and phosphorylases.\\ | 2008 | Journal of medicinal chemistry, Feb-28, Volume: 51, Issue:4
| Azetidine based transition state analogue inhibitors of N-ribosyl hydrolases and phosphorylases. |
AID1347411 | qHTS to identify inhibitors of the type 1 interferon - major histocompatibility complex class I in skeletal muscle: primary screen against the NCATS Mechanism Interrogation Plate v5.0 (MIPE) Libary | 2020 | ACS chemical biology, 07-17, Volume: 15, Issue:7
| High-Throughput Screening to Identify Inhibitors of the Type I Interferon-Major Histocompatibility Complex Class I Pathway in Skeletal Muscle. |
AID1811 | Experimentally measured binding affinity data derived from PDB | 2005 | The Journal of biological chemistry, May-06, Volume: 280, Issue:18
| Structural rationale for the affinity of pico- and femtomolar transition state analogues of Escherichia coli 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase. |
AID977610 | Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB | 2005 | The Journal of biological chemistry, May-06, Volume: 280, Issue:18
| Structural rationale for the affinity of pico- and femtomolar transition state analogues of Escherichia coli 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase. |
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |