Picloram-methyl is a herbicide that is widely used for controlling broadleaf weeds in agricultural and non-agricultural settings. It is a synthetic compound with the chemical name 4-amino-3,5,6-trichloro-2-pyridinecarboxylic acid methyl ester. It is typically formulated as an amine salt and is applied as a granular or liquid formulation. Picloram-methyl is a systemic herbicide, meaning that it is absorbed by plants and translocated throughout the plant. It disrupts plant growth by inhibiting the synthesis of essential amino acids. Picloram-methyl is known for its persistence in the environment, with a half-life of several months to several years, depending on soil conditions and climate. Due to its persistence, it can accumulate in soil and water, posing potential risks to human and animal health. It has been found to contaminate groundwater and surface water, affecting aquatic life and human health. It has also been associated with adverse effects on human health, including cancer. Its persistence and potential for environmental and health impacts have led to concerns regarding its use and disposal. Researchers study picloram-methyl to investigate its environmental fate and transport, develop strategies for reducing its persistence and risk to human and environmental health, and explore alternative herbicides with lower environmental impact.'
picloram-methyl : A methyl ester resulting from the formal condensation of the carboxy group of picloram with methanol. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]
| ID Source | ID |
|---|---|
| PubMed CID | 84224 |
| CHEMBL ID | 1321408 |
| CHEBI ID | 145557 |
| SCHEMBL ID | 1614180 |
| Synonym |
|---|
| 2-pyridinecarboxylic acid, 4-amino-3,5,6-trichloro-, methyl ester |
| picolinic acid, 4-amino-3,5,6-trichloro-, methyl ester |
| methyl 4-amino-3,5,6-trichloropyridine-2-carboxylate |
| STK448063 |
| smr000348919 |
| MLS001005673 , |
| 4-amino-3,5,6-trichloropicolinic acid methyl ester |
| picloram methyl ester |
| picloram-methyl |
| 4-amino-3,5,6-trichloro-2-pyridinecarboxylic acid methyl ester |
| 14143-55-6 |
| methyl 4-amino-3,5,6-trichloro-2-pyridinecarboxylate |
| methyl 4-amino-3,5,6-trichloropicolinate |
| CHEBI:145557 |
| AKOS001026959 |
| NCGC00245990-01 |
| HMS2731A10 |
| unii-30933810wn |
| picloram-methyl [iso] |
| 30933810wn , |
| methyl 4-amino-3,5,6-trichloro-2-picolinate |
| SCHEMBL1614180 |
| cyanine863 |
| cid_84224 |
| 4-amino-3,5,6-trichloro-picolinic acid methyl ester |
| bdbm63676 |
| methyl 4-azanyl-3,5,6-tris(chloranyl)pyridine-2-carboxylate |
| AE-641/03316048 |
| CHEMBL1321408 |
| picloram-methyl ester |
| methyl 4-amino-3,5,6-trichloro-2-pyridinecarboxylate # |
| RJQUHEYNLDNJLN-UHFFFAOYSA-N |
| pichloram methyl ester |
| J-007500 |
| CS-0206074 |
| Q27255934 |
| BS-21443 |
| DTXSID30864470 |
| E85568 |
| EN300-2008395 |
| Role | Description |
|---|---|
| herbicide | A substance used to destroy plant pests. |
| [role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Class | Description |
|---|---|
| aminopyridine | Compounds containing a pyridine skeleton substituted by one or more amine groups. |
| chloropyridine | Compounds containing a pyridine nucleus substituted with one or more chlorine atoms. |
| methyl ester | Any carboxylic ester resulting from the formal condensation of a carboxy group with methanol. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Protein | Taxonomy | Measurement | Average (µ) | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| glp-1 receptor, partial | Homo sapiens (human) | Potency | 11.2202 | 0.0184 | 6.8060 | 14.1254 | AID624417 |
| ClpP | Bacillus subtilis | Potency | 31.6228 | 1.9953 | 22.6730 | 39.8107 | AID651965 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 89.1251 | 0.0501 | 27.0736 | 89.1251 | AID588590 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Hsf1 protein | Mus musculus (house mouse) | EC50 (µMol) | 195.0000 | 0.1600 | 24.4900 | 236.5000 | AID2382 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID504810 | Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7 | A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID651635 | Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression | |||
| AID504812 | Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7 | A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID1745845 | Primary qHTS for Inhibitors of ATXN expression | |||
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 3 (60.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.56) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 5 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||