Page last updated: 2024-10-06

Tryptophan catabolism

Proteins (14)

ProteinSynonymsTaxonomy
2-amino-3-carboxymuconate-6-semialdehyde decarboxylaseEC 4.1.1.45; Picolinate carboxylaseHomo sapiens (human)
Indoleamine 2,3-dioxygenase 1IDO-1; EC 1.13.11.52; Indoleamine-pyrrole 2,3-dioxygenaseHomo sapiens (human)
Indoleamine 2,3-dioxygenase 2IDO-2; EC 1.13.11.-; Indoleamine 2,3-dioxygenase-like protein 1; Indoleamine-pyrrole 2,3-dioxygenase-like protein 1Homo sapiens (human)
Large neutral amino acids transporter small subunit 14F2 light chain; 4F2 LC; 4F2LC; CD98 light chain; Integral membrane protein E16; E16; L-type amino acid transporter 1; hLAT1; Solute carrier family 7 member 5; y+ system cationic amino acid transporterHomo sapiens (human)
KynureninaseEC 3.7.1.3; L-kynurenine hydrolaseHomo sapiens (human)
Kynurenine--oxoglutarate transaminase 3EC 2.6.1.7; Cysteine-S-conjugate beta-lyase 2; 4.4.1.13; Kynurenine aminotransferase 3; Kynurenine aminotransferase III; KATIII; Kynurenine--glyoxylate transaminase; 2.6.1.63; Kynurenine--oxoglutarate transaminase IIIHomo sapiens (human)
Tryptophan 2,3-dioxygenaseTDO; EC 1.13.11.11; Tryptamin 2,3-dioxygenase; Tryptophan oxygenase; TO; TRPO; Tryptophan pyrrolase; TryptophanaseHomo sapiens (human)
Kynurenine--oxoglutarate transaminase 1EC 2.6.1.7; Cysteine-S-conjugate beta-lyase; 4.4.1.13; Glutamine transaminase K; GTK; Glutamine--phenylpyruvate transaminase; 2.6.1.64; Kynurenine aminotransferase 1; Kynurenine aminotransferase I; KATI; Kynurenine--oxoglutarate transaminase IHomo sapiens (human)
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrialKAT/AadAT; 2-aminoadipate aminotransferase; 2-aminoadipate transaminase; 2.6.1.39; Alpha-aminoadipate aminotransferase; AadAT; Kynurenine aminotransferase II; Kynurenine--oxoglutarate aminotransferase II; Kynurenine--oxoglutarate transaminase 2; 2.6.1.7; Homo sapiens (human)
Kynurenine formamidaseKFA; KFase; EC 3.5.1.9; Arylformamidase; N-formylkynurenine formamidase; FKFHomo sapiens (human)
Kynurenine 3-monooxygenaseEC 1.14.13.9; Kynurenine 3-hydroxylaseHomo sapiens (human)
3-hydroxyanthranilate 3,4-dioxygenaseEC 1.13.11.6; 3-hydroxyanthranilate oxygenase; 3-HAO; h3HAO; 3-hydroxyanthranilic acid dioxygenase; HADHomo sapiens (human)
4F2 cell-surface antigen heavy chain4F2hc; 4F2 heavy chain antigen; Lymphocyte activation antigen 4F2 large subunit; Solute carrier family 3 member 2Homo sapiens (human)
Proton-coupled amino acid transporter 4Proton/amino acid transporter 4; Solute carrier family 36 member 4Homo sapiens (human)

Compounds (19)

CompoundDescription
hydronium ion
NADH
ironA metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBINS; CYTOCHROMES; and IRON-BINDING PROTEINS. It plays a role in cellular redox reactions and in the transport of OXYGEN.
Carbon DioxideA colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals.
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
OxygenAn element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.
Pyruvic AcidAn intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed)
3-hydroxykynurenine, (L)-isomer
nadA coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed)
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
kynurenineA metabolite of the essential amino acid tryptophan metabolized via the tryptophan-kynurenine pathway.
alpha-Ketoglutarate
formate
kynurenic acidA broad-spectrum excitatory amino acid antagonist used as a research tool.
glutamate
3-hydroxyanthranilic acidAn oxidation product of tryptophan metabolism. It may be a free radical scavenger and a carcinogen.
N'-formylkynureninea photochemical breakdown product of tryptophan in proteins; RN given refers to parent cpd without isomeric designation
hemeThe color-furnishing portion of hemoglobin. It is found free in tissues and as the prosthetic group in many hemeproteins.