A kynurenine--oxoglutarate transaminase 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6YP21]
EC 2.6.1.7;
Cysteine-S-conjugate beta-lyase 2;
4.4.1.13;
Kynurenine aminotransferase 3;
Kynurenine aminotransferase III;
KATIII;
Kynurenine--glyoxylate transaminase;
2.6.1.63;
Kynurenine--oxoglutarate transaminase III
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| pf-04859989 | Homo sapiens (human) | IC50 | 10.0200 | 2 | 2 |
This protein enables 6 target(s):
| Target | Category | Definition |
|---|---|---|
| RNA binding | molecular function | Binding to an RNA molecule or a portion thereof. [GOC:jl, GOC:mah] |
| kynurenine-oxoglutarate transaminase activity | molecular function | Catalysis of the reaction: L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate. [EC:2.6.1.7] |
| pyridoxal phosphate binding | molecular function | Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. [GOC:mah, ISBN:0198506732] |
| protein homodimerization activity | molecular function | Binding to an identical protein to form a homodimer. [GOC:jl] |
| kynurenine-glyoxylate transaminase activity | molecular function | Catalysis of the reaction: L-kynurenine + glyoxylate = 4-(2-aminophenyl)-2,4-dioxobutanoate + glycine. [EC:2.6.1.63, RHEA:19249] |
| cysteine-S-conjugate beta-lyase activity | molecular function | Catalysis of the reaction: S-substituted L-cysteine + H2O = a thiol + NH4+ + pyruvate. [RHEA:18121] |
This protein is active in 2 target(s):
| Target | Category | Definition |
|---|---|---|
| cytoplasm | cellular component | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684] |
| mitochondrion | cellular component | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. [GOC:giardia, ISBN:0198506732] |
This protein is involved in 5 target(s):
| Target | Category | Definition |
|---|---|---|
| 2-oxoglutarate metabolic process | biological process | The chemical reactions and pathways involving oxoglutarate, the dianion of 2-oxoglutaric acid. It is a key constituent of the TCA cycle and a key intermediate in amino-acid metabolism. [ISBN:0198506732] |
| amino acid metabolic process | biological process | The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups. [ISBN:0198506732] |
| biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. [GOC:curators, ISBN:0198547684] |
| kynurenine metabolic process | biological process | The chemical reactions and pathways involving kynurenine, the amino acid 3-(2-aminobenzoyl)-alanine. [CHEBI:28683, GOC:mah, GOC:rph] |
| L-kynurenine catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of L-kynurenine, the L-enantiomer of the amino acid kynurenine (3-(2-aminobenzoyl)-alanine). [GOC:yaf] |