Page last updated: 2024-10-06

Nicotinate metabolism

Proteins (22)

ProteinSynonymsTaxonomy
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2EC 3.2.2.6; ADP-ribosyl cyclase 2; Bone marrow stromal antigen 1; BST-1; Cyclic ADP-ribose hydrolase 2; cADPr hydrolase 2Homo sapiens (human)
Prostaglandin G/H synthase 2EC 1.14.99.1; Cyclooxygenase-2; COX-2; PHS II; Prostaglandin H2 synthase 2; PGH synthase 2; PGHS-2; Prostaglandin-endoperoxide synthase 2Homo sapiens (human)
Glutamine-dependent NAD(+) synthetaseEC 6.3.5.1; NAD(+) synthase [glutamine-hydrolyzing]; NAD(+) synthetaseHomo sapiens (human)
NAD kinaseEC 2.7.1.23; Poly(P)/ATP NAD kinaseHomo sapiens (human)
Nicotinamide phosphoribosyltransferaseNAmPRTase; Nampt; EC 2.4.2.12; Pre-B-cell colony-enhancing factor 1; Pre-B cell-enhancing factor; VisfatinHomo sapiens (human)
Nicotinamide N-methyltransferaseEC 2.1.1.1Homo sapiens (human)
Nicotinate phosphoribosyltransferaseNAPRTase; EC 6.3.4.21; FHA-HIT-interacting protein; Nicotinate phosphoribosyltransferase domain-containing protein 1Homo sapiens (human)
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1NMN/NaMN adenylyltransferase 1; EC 2.7.7.1; EC 2.7.7.18; Nicotinamide-nucleotide adenylyltransferase 1; NMN adenylyltransferase 1; Nicotinate-nucleotide adenylyltransferase 1; NaMN adenylyltransferase 1Homo sapiens (human)
5'-nucleotidase5'-NT; EC 3.1.3.5; Ecto-5'-nucleotidaseHomo sapiens (human)
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1EC 3.2.2.6; 2'-phospho-ADP-ribosyl cyclase; 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase; 2.4.99.20; 2'-phospho-cyclic-ADP-ribose transferase; ADP-ribosyl cyclase 1; ADPRC 1; Cyclic ADP-ribose hydrolase 1; cADPr hydrolase 1; T10Homo sapiens (human)
RenalaseEC 1.6.3.5; Monoamine oxidase-C; MAO-CHomo sapiens (human)
NAD kinase 2, mitochondrialEC 2.7.1.23; Mitochondrial NAD kinase; NAD kinase domain-containing protein 1, mitochondrialHomo sapiens (human)
Nicotinamide riboside kinase 2NRK 2; NmR-K 2; EC 2.7.1.22; Integrin beta-1-binding protein 3; Muscle integrin-binding protein; MIBP; Nicotinic acid riboside kinase 2; 2.7.1.173; Ribosylnicotinamide kinase 2; RNK 2; Ribosylnicotinic acid kinase 2Homo sapiens (human)
Nicotinamide riboside kinase 1NRK 1; NmR-K 1; EC 2.7.1.22; Nicotinic acid riboside kinase 1; 2.7.1.173; Ribosylnicotinamide kinase 1; RNK 1; Ribosylnicotinic acid kinase 1Homo sapiens (human)
ATP-dependent (S)-NAD(P)H-hydrate dehydrataseEC 4.2.1.93; ATP-dependent NAD(P)HX dehydratase; Carbohydrate kinase domain-containing protein; NAD(P)HX dehydrataseHomo sapiens (human)
NAD(P)H-hydrate epimeraseEC 5.1.99.6; Apolipoprotein A-I-binding protein; AI-BP; NAD(P)HX epimerase; YjeF N-terminal domain-containing protein 1; YjeF_N1Homo sapiens (human)
Nicotinate-nucleotide pyrophosphorylase [carboxylating]EC 2.4.2.19; Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase; QPRTaseHomo sapiens (human)
Sodium-coupled monocarboxylate transporter 1Apical iodide transporter; Electrogenic sodium monocarboxylate cotransporter; Sodium iodide-related cotransporter; Solute carrier family 5 member 8Homo sapiens (human)
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3NMN/NaMN adenylyltransferase 3; Nicotinamide-nucleotide adenylyltransferase 3; NMN adenylyltransferase 3; Nicotinate-nucleotide adenylyltransferase 3; NaMN adenylyltransferase 3; 2.7.7.18; Pyridine nucleotide adenylyltransferase 3; PNAT-3; 2.7.7.1Homo sapiens (human)
NAD-capped RNA hydrolase NUDT12DeNADding enzyme NUDT12; EC 3.6.1.-; NADH pyrophosphatase NUDT12; 3.6.1.22; Nucleoside diphosphate-linked moiety X motif 12; Nudix motif 12Homo sapiens (human)
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2NMN/NaMN adenylyltransferase 2; EC 2.7.7.1; EC 2.7.7.18; Nicotinamide mononucleotide adenylyltransferase 2; NMN adenylyltransferase 2; Nicotinate-nucleotide adenylyltransferase 2; NaMN adenylyltransferase 2Homo sapiens (human)
Solute carrier family 22 member 13Organic cation transporter-like 3; ORCTL-3Homo sapiens (human)

Compounds (32)

CompoundDescription
hydronium ion
NADH
Carbon DioxideA colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals.
ZincA metallic element of atomic number 30 and atomic weight 65.38. It is a necessary trace element in the diet, forming an essential part of many enzymes, and playing an important role in protein synthesis and in cell division. Zinc deficiency is associated with ANEMIA, short stature, HYPOGONADISM, impaired WOUND HEALING, and geophagia. It is known by the symbol Zn.
Orthophosphate
epoprostenolA prostaglandin that is a powerful vasodilator and inhibits platelet aggregation. It is biosynthesized enzymatically from PROSTAGLANDIN ENDOPEROXIDES in human vascular tissue. The sodium salt has been also used to treat primary pulmonary hypertension (HYPERTENSION, PULMONARY).
adenosine diphosphateAdenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.
Hydrogen PeroxideA strong oxidizing agent used in aqueous solution as a ripening agent, bleach, and topical anti-infective. It is relatively unstable and solutions deteriorate over time unless stabilized by the addition of acetanilide or similar organic materials.
MagnesiumA metallic element that has the atomic symbol Mg, atomic number 12, and atomic weight 24.31. It is important for the activity of many enzymes, especially those involved in OXIDATIVE PHOSPHORYLATION.
SodiumA member of the alkali group of metals. It has the atomic symbol Na, atomic number 11, and atomic weight 23.
niacinamideAn important compound functioning as a component of the coenzyme NAD. Its primary significance is in the prevention and/or cure of blacktongue and PELLAGRA. Most animals cannot manufacture this compound in amounts sufficient to prevent nutritional deficiency and it therefore must be supplemented through dietary intake.
Nico-400
niacinA water-soluble vitamin of the B complex occurring in various animal and plant tissues. It is required by the body for the formation of coenzymes NAD and NADP. It has PELLAGRA-curative, vasodilating, and antilipemic properties.
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
OxygenAn element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.
adenosine monophosphateAdenine nucleotide containing one phosphate group esterified to the sugar moiety in the 2'-, 3'-, or 5'-position.
nadA coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed)
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
nicotinate ribonucleoside
nicotinamide-beta-riboside
prostaglandin h2A cyclic endoperoxide intermediate produced by the action of CYCLOOXYGENASE on ARACHIDONIC ACID. It is further converted by a series of specific enzymes to the series 2 prostaglandins.
n(1)-methylnicotinamideRN given refers to parent cpd
prostaglandin g2
glutamate
Quinolinate
adenosine triphosphateAn adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
polyglutamineRN given for (D)-isomer
nicotinic acid adenine dinucleotideintermediate in the biosynthesis of NAD
s-adenosylmethioninePhysiologic methyl radical donor involved in enzymatic transmethylation reactions and present in all living organisms. It possesses anti-inflammatory activity and has been used in treatment of chronic liver disease. (From Merck, 11th ed)
Nicotinamide Mononucleotide3-Carbamoyl-1-beta-D-ribofuranosyl pyridinium hydroxide-5'phosphate, inner salt. A nucleotide in which the nitrogenous base, nicotinamide, is in beta-N-glycosidic linkage with the C-1 position of D-ribose. Synonyms: Nicotinamide Ribonucleotide; NMN.
Flavin-Adenine DinucleotideA condensation product of riboflavin and adenosine diphosphate. The coenzyme of various aerobic dehydrogenases, e.g., D-amino acid oxidase and L-amino acid oxidase. (Lehninger, Principles of Biochemistry, 1982, p972)
creolinfrom refined coal tar oils