Compounds > tolvaptan
Page last updated: 2024-09-05

tolvaptan and digoxin

tolvaptan has been researched along with digoxin in 3 studies

Compound Research Comparison

Studies
(tolvaptan)		Trials
(tolvaptan)		Recent Studies (post-2010)
(tolvaptan)		Studies
(digoxin)		Trials
(digoxin)		Recent Studies (post-2010) (digoxin)
96717278611,4839581,289

Protein Interaction Comparison

ProteinTaxonomytolvaptan (IC50)digoxin (IC50)
STAT3, partialHomo sapiens (human)1.862
Sodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)0.32
Sodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)0.335
Sodium/potassium-transporting ATPase subunit alpha-2Rattus norvegicus (Norway rat)0.22
Sodium/potassium-transporting ATPase subunit alpha-3 Rattus norvegicus (Norway rat)0.22
Sodium/potassium-transporting ATPase subunit beta-1 Rattus norvegicus (Norway rat)0.0055
Replicase polyprotein 1abSevere acute respiratory syndrome coronavirus 20.19
Sodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)0.335
Sodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)0.335
Sodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)0.335
Sodium/potassium-transporting ATPase subunit alpha-1Canis lupus familiaris (dog)0.5
Nuclear receptor ROR-gammaHomo sapiens (human)3.4798
Sodium/potassium-transporting ATPase subunit beta-3Homo sapiens (human)0.335
Sodium/potassium-transporting ATPase subunit gammaHomo sapiens (human)0.335
Sodium/potassium-transporting ATPase subunit alpha-4Homo sapiens (human)0.335
Sodium/potassium-transporting ATPase subunit alpha-4Rattus norvegicus (Norway rat)0.0055
Solute carrier organic anion transporter family member 1B1Homo sapiens (human)3.2359

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's3 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Bricmont, P; Furukawa, M; Kashiyama, E; Mallikaarjun, S; Ninomiya, S; Ohzone, Y; Shoaf, SE1
Butler, J; Gheorghiade, M; Greene, SJ; Harinstein, ME; Konstam, MA; Maggioni, AP; Subačius, H; Swedberg, K; Vaduganathan, M; Zannad, F1

Reviews

1 review(s) available for tolvaptan and digoxin

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Trials

2 trial(s) available for tolvaptan and digoxin

ArticleYear
In vitro P-glycoprotein interactions and steady-state pharmacokinetic interactions between tolvaptan and digoxin in healthy subjects.
    Journal of clinical pharmacology, 2011, Volume: 51, Issue:5

    Topics: Administration, Oral; Adolescent; Adult; Analysis of Variance; Animals; Antidiuretic Hormone Receptor Antagonists; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzazepines; Cardiotonic Agents; Digoxin; Drug Administration Schedule; Drug Interactions; Female; Florida; Hormone Antagonists; Humans; LLC-PK1 Cells; Male; Metabolic Clearance Rate; Models, Biological; Swine; Tolvaptan; Transfection; Young Adult

2011
Prognostic value of monocyte count in patients hospitalized for heart failure with reduced ejection fraction (from the EVEREST Trial).
    The American journal of cardiology, 2012, Dec-01, Volume: 110, Issue:11

    Topics: Angiotensin-Converting Enzyme Inhibitors; Antidiuretic Hormone Receptor Antagonists; Benzazepines; Cardiotonic Agents; Digoxin; Double-Blind Method; Follow-Up Studies; Heart Failure; Hospital Mortality; Humans; Inpatients; Kaplan-Meier Estimate; Leukocyte Count; Monocytes; Prognosis; Prospective Studies; Stroke Volume; Survival Rate; Tolvaptan

2012