Compounds > verrucosin
Page last updated: 2024-11-12

verrucosin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

verrucosin: disrupts ion homeostasis in the presence of acridine orange; isolated from Virola oleifera; structure in first source; do not confuse with either verrucosin A or verrucosin B [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

FloraRankFlora DefinitionFamilyFamily Definition
Virolagenus[no description available]MyristicaceaeA family of flowering plants in the order Magnoliales. Many of the species are tropical and have fragrant wood and leaves.[MeSH]

Cross-References

ID SourceID
PubMed CID10736226
CHEMBL ID3601519
SCHEMBL ID893163
MeSH IDM0561342

Synonyms (7)

Synonym
SCHEMBL893163
CHEMBL3601519 ,
bdbm50242959
E88918
CS-0527353
HY-N10396
verrucosin
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (1)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Sialidase AStreptococcus pneumoniaeIC50 (µMol)37.20000.30005.050010.0000AID1467530
Sialidase AStreptococcus pneumoniaeKi21.90000.10002.92839.4000AID1467531
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (15)

Assay IDTitleYearJournalArticle
AID1467533Inhibition of Streptococcus pneumoniae sialidase NanC using 4-methylumbelliferyl-alpha-D-N-acetylneuraminic acid as substrate after 60 mins by FRET assay2017Bioorganic & medicinal chemistry letters, 07-15, Volume: 27, Issue:14
Sialidase inhibitory activity of diarylnonanoid and neolignan compounds extracted from the seeds of Myristica fragrans.
AID1239180Neuroprotective activity in mouse HT22 cells assessed as decrease of glutamate-induced decrease in Bcl-2 protein expression at 30 uM pretreated 30 mins before glutamate challenge measured after 12 hrs by Western blotting assay2015Journal of natural products, Aug-28, Volume: 78, Issue:8
Neolignans from Aristolochia fordiana Prevent Oxidative Stress-Induced Neuronal Death through Maintaining the Nrf2/HO-1 Pathway in HT22 Cells.
AID1467529Inhibition of Streptococcus pneumoniae sialidase NanB using 4-methylumbelliferyl-alpha-D-N-acetylneuraminic acid as substrate after 60 mins by FRET assay2017Bioorganic & medicinal chemistry letters, 07-15, Volume: 27, Issue:14
Sialidase inhibitory activity of diarylnonanoid and neolignan compounds extracted from the seeds of Myristica fragrans.
AID1467530Inhibition of Streptococcus pneumoniae sialidase NanA using 4-methylumbelliferyl-alpha-D-N-acetylneuraminic acid as substrate after 60 mins by FRET assay2017Bioorganic & medicinal chemistry letters, 07-15, Volume: 27, Issue:14
Sialidase inhibitory activity of diarylnonanoid and neolignan compounds extracted from the seeds of Myristica fragrans.
AID1239174Neuroprotective activity in mouse HT22 cells assessed as protection against glutamate-induced cell death pretreated 30 mins before glutamate challenge measured after 24 hrs by MTT assay2015Journal of natural products, Aug-28, Volume: 78, Issue:8
Neolignans from Aristolochia fordiana Prevent Oxidative Stress-Induced Neuronal Death through Maintaining the Nrf2/HO-1 Pathway in HT22 Cells.
AID1239172Neuroprotective activity in mouse HT22 cells assessed as protection against glutamate-induced cell death at 1 to 30 uM pretreated 30 mins before glutamate challenge measured after 24 hrs by MTT assay2015Journal of natural products, Aug-28, Volume: 78, Issue:8
Neolignans from Aristolochia fordiana Prevent Oxidative Stress-Induced Neuronal Death through Maintaining the Nrf2/HO-1 Pathway in HT22 Cells.
AID1239176Cytotoxicity against mouse HT22 cells assessed as induction of cell proliferation at 30 uM after 24 hrs by MTT assay2015Journal of natural products, Aug-28, Volume: 78, Issue:8
Neolignans from Aristolochia fordiana Prevent Oxidative Stress-Induced Neuronal Death through Maintaining the Nrf2/HO-1 Pathway in HT22 Cells.
AID1239177Neuroprotective activity in mouse HT22 cells assessed as decrease of glutamate-induced ROS production at 30 uM pretreated 30 mins before glutamate challenge measured after 12 hrs using H2DCF-DA staining by fluorescence assay2015Journal of natural products, Aug-28, Volume: 78, Issue:8
Neolignans from Aristolochia fordiana Prevent Oxidative Stress-Induced Neuronal Death through Maintaining the Nrf2/HO-1 Pathway in HT22 Cells.
AID1239178Neuroprotective activity in mouse HT22 cells assessed as decrease of glutamate-induced decrease in Nrf2/HO-1 protein expression at 30 uM pretreated 30 mins before glutamate challenge measured after 12 hrs by Western blotting assay2015Journal of natural products, Aug-28, Volume: 78, Issue:8
Neolignans from Aristolochia fordiana Prevent Oxidative Stress-Induced Neuronal Death through Maintaining the Nrf2/HO-1 Pathway in HT22 Cells.
AID1467531Noncompetitive inhibition of Streptococcus pneumoniae sialidase NanA using 4-methylumbelliferyl-alpha-D-N-acetylneuraminic acid as substrate after 60 mins by Lineweaver-Burk plot/Dixon plot analysis2017Bioorganic & medicinal chemistry letters, 07-15, Volume: 27, Issue:14
Sialidase inhibitory activity of diarylnonanoid and neolignan compounds extracted from the seeds of Myristica fragrans.
AID1239171Cytotoxicity against mouse HT22 cells assessed as cell viability at 30 uM after 24 hrs by MTT assay2015Journal of natural products, Aug-28, Volume: 78, Issue:8
Neolignans from Aristolochia fordiana Prevent Oxidative Stress-Induced Neuronal Death through Maintaining the Nrf2/HO-1 Pathway in HT22 Cells.
AID1327072Antagonist activity at human EGFP-fused CCR3 expressed in mouse L1.2 cells assessed as inhibition of CCL11-induced chemotaxis at 1 uM measured after 1.5 hrs by PicoGreen dsDNA reagent-based assay2016Journal of natural products, 08-26, Volume: 79, Issue:8
Neolignans from the Arils of Myristica fragrans as Potent Antagonists of CC Chemokine Receptor 3.
AID1239179Effect on Nrf2/HO-1 protein expression in mouse HT22 cells at 30 uM after 24 hrs by Western blotting assay2015Journal of natural products, Aug-28, Volume: 78, Issue:8
Neolignans from Aristolochia fordiana Prevent Oxidative Stress-Induced Neuronal Death through Maintaining the Nrf2/HO-1 Pathway in HT22 Cells.
AID1239175Neuroprotective activity in mouse HT22 cells assessed as protection against glutamate-induced change in cell morphology at 1 to 30 uM pretreated 30 mins before glutamate challenge measured after 24 hrs by MTT assay2015Journal of natural products, Aug-28, Volume: 78, Issue:8
Neolignans from Aristolochia fordiana Prevent Oxidative Stress-Induced Neuronal Death through Maintaining the Nrf2/HO-1 Pathway in HT22 Cells.
AID1239173Neuroprotective activity in mouse HT22 cells assessed as decrease of glutamate-induced increase in LDH level at 10 to 30 uM pretreated 30 mins before glutamate challenge measured after 24 hrs2015Journal of natural products, Aug-28, Volume: 78, Issue:8
Neolignans from Aristolochia fordiana Prevent Oxidative Stress-Induced Neuronal Death through Maintaining the Nrf2/HO-1 Pathway in HT22 Cells.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's5 (83.33)24.3611
2020's1 (16.67)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 35.39

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index35.39 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.57 (4.65)
Search Engine Demand Index91.05 (26.88)
Search Engine Supply Index4.00 (0.95)

This Compound (35.39)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
myristicin
myristicin: asaricin is an isomer; structure; a methylene dioxy version of elemicin;		2.5420organic molecular entitymetabolite
acridine orange
Acridine Orange: A cationic cytochemical stain specific for cell nuclei, especially DNA. It is used as a supravital stain and in fluorescence cytochemistry. It may cause mutations in microorganisms.. acridine orange : Fluorescent dye useful for cell cycle determination. It is cell-permeable, and interacts with DNA and RNA by intercalation or electrostatic attractions respectively.. acridine orange free base : A member of the class of aminoacridines that is acridine carrying two dimethylamino substituents at positions 3 and 6. The hydrochloride salt is the fluorescent dye 'acridine orange', used for cell cycle determination.		2.0610aminoacridines;
aromatic amine;
tertiary amino compound		fluorochrome;
histological dye
2-deoxy-2,3-dehydro-n-acetylneuraminic acid
2-deoxy-2,3-dehydro-N-acetylneuraminic acid: also known as NeuAc2en, but this is also synonym for another compound. 2-deoxy-2,3-dehydro-N-acetylneuraminic acid : N-Acetylneuraminic acid reduced across the 2,3-bond with loss of the hydroxy group at C-2; it is a minor component of body fluids although abundant in sialuria.		2.1510N-acetylneuraminic acids
malabaricone c
malabaricone C: from maize (Myristica fragrans); structure given in first source		2.1510butanonemetabolite
nectandrin-b
nectandrin-B: antifungal lignan from the seeds of Myristica fragrans; structure in first source		2.5220
malabaricone b
malabaricone B: from maize (Myristica fragrans); structure given in first source		2.1510
4-allyl-2,6-dimethoxyphenol
4-allyl-2,6-dimethoxyphenol: structure in first source. 4-allyl-2,6-dimethoxyphenol : A member of the class of phenols that is phenol substituted by an allyl group at position 4 and methoxy groups at positions 2 and 6 respectively.		2.1510dimethoxybenzene;
phenols;
phenylpropanoid
lignans
Lignans: A class of dibenzylbutane derivatives which occurs in higher plants and in fluids (bile, serum, urine, etc.) in man and other animals. These compounds, which have a potential anti-cancer role, can be synthesized in vitro by human fecal flora. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)		3.0440
Licarin A
[no description available]		2.1510benzofurans
eupomatenoid 6
eupomatenoid 6: RN given for (E)-isomer; structure in first source. rataniaphenol II : A member of the class of benzofurans that is 1-benzofuran substituted by a 4-hydroxyphenyl group at position 2, a methyl group at position 3 and a prop-1-en-1-yl group at position 5. It is a lignan derivative isolated from the roots of Krameria lappacea.		2.1110benzofurans;
phenols		anti-inflammatory agent;
cyclooxygenase 1 inhibitor;
cyclooxygenase 2 inhibitor;
NF-kappaB inhibitor;
plant metabolite
sb 328437
SB 328437: a CC chemokine receptor-3 antagonist that inhibits binding of eotaxin and monocyte chemotactic protein-4 to eosinophils; structure in first source		2.1310
ConditionIndicatedRelationship StrengthStudiesTrials
Bilharziasis
[description not available]		02.4110
Schistosoma mansoni Infection
[description not available]		02.4110
Schistosomiasis
Infection with flukes (trematodes) of the genus SCHISTOSOMA. Three species produce the most frequent clinical diseases: SCHISTOSOMA HAEMATOBIUM (endemic in Africa and the Middle East), SCHISTOSOMA MANSONI (in Egypt, northern and southern Africa, some West Indies islands, northern 2/3 of South America), and SCHISTOSOMA JAPONICUM (in Japan, China, the Philippines, Celebes, Thailand, Laos). S. mansoni is often seen in Puerto Ricans living in the United States.		02.4110
Schistosomiasis mansoni
Schistosomiasis caused by Schistosoma mansoni. It is endemic in Africa, the Middle East, South America, and the Caribbean and affects mainly the bowel, spleen, and liver.		02.4110