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tas 301

Description

TAS 301: an inhibitor of smooth muscle cell migration and proliferation; structure in first source [MeSH]

3-[bis(4-methoxyphenyl)methylidene]-1H-indol-2-one : no description available [CHeBI]

Cross-References

ID Source	ID
PubMed CID	9885087
CHEMBL ID	1377300
SCHEMBL ID	725960
CHEBI ID	92970
MeSH ID	M0291519

Synonyms (33)

Synonym
BRD-K55454768-001-01-8
NCGC00165914-01
HSCI1_000146
tas-301
tas 301
3-bis-(4-methoxphenyl)methylene-2-indolinone
193620-69-8
S6424
3-[bis-(4-methoxy-phenyl)-methylene]-1,3-dihydro-indol-2-one
3-[bis(4-methoxyphenyl)methylene]-oxindole
KUEYYIJXBRWZIB-UHFFFAOYSA-N
SCHEMBL725960
CS-5012
3-[bis(4-methoxyphenyl)methylene]-1,3-dihydro-2h-indol-2-one
AC-35429
CHEMBL1377300
HY-18965
AKOS024458201
DTXSID80432401
mfcd05865245
J-690254
(3r)-3-benzyl-n,n',n'-trimethyl-3-piperidinecarbohydrazide hydrochloride
EX-A801
tas301
3-[bis(4-methoxyphenyl)methylidene]-2,3-dihydro-1h-indol-2-one
CHEBI:92970
tas-301, >=95% (hplc), solid
BCP16653
3-[bis(4-methoxyphenyl)methylidene]-1h-indol-2-one
Q27164703
FT-0700251
3-(bis(4-methoxyphenyl)methylene)indolin-2-one
AS-55912

Drug Classes (1)

Class	Description
diarylmethane	Any compound containing two aryl groups connected by a single C atom.

Protein Targets (2)

Potency Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	Homo sapiens (human)	Potency	15.8489	AID2517
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	Homo sapiens (human)	Potency	5.0119	AID485290

Research

Studies (6)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	1 (16.67)	18.2507
2000's	5 (83.33)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	6 (100.00%)	84.16%

Substance	Classes	Roles	Relationship Strength
b 844-39	diarylmethane		low
3-[(4-chlorophenyl)-phenylmethoxy]-8-methyl-8-azabicyclo[3.2.1]octane	diarylmethane		low
adiphenine	diarylmethane		low
3-(2'-aminobenzhydryloxy)tropane	diarylmethane		low
2,2-bis(4-glycidyloxyphenyl)propane	diarylmethane		low
benproperine	diarylmethane		low
cogentin	diarylmethane		low
bifemelane	diarylmethane		low
bisacodyl	diarylmethane		low
chlorcyclizine	diarylmethane		low
cifenline	diarylmethane		low
clidinium	diarylmethane		low
clofedanol	diarylmethane; tertiary amino compound	antitussive	low
clofoctol	diarylmethane		low
cloperastine	diarylmethane		low
r 59022	diarylmethane		low
dichlorophen	bridged diphenyl fungicide; diarylmethane		low
fendiline	diarylmethane		low
1-[bis(4-fluorophenyl)methyl]-4-(3-phenylprop-2-enyl)piperazine	diarylmethane		low
fluspirilene	diarylmethane		low
homochlorocyclizine	diarylmethane		low
isopropamide iodide	diarylmethane		low
lidoflazine	diarylmethane		low
lomerizine	diarylmethane		low
manidipine	diarylmethane		low
meclizine	diarylmethane		low
mepenzolate	diarylmethane		low
methadone	benzenes; diarylmethane; ketone; tertiary amino compound		low
mitotane	diarylmethane		low
no 711	diarylmethane		low
oxatomide	benzimidazoles; diarylmethane; N-alkylpiperazine	anti-allergic agent; anti-inflammatory agent; geroprotector; H1-receptor antagonist; serotonergic antagonist	low
pipenzolate	diarylmethane		low
piperidolate	diarylmethane		low
proadifen	diarylmethane		low
propiverine	diarylmethane		low
aurin	diarylmethane		low
dpi 201-106	diarylmethane		low
terfenadine	diarylmethane		low
isopropamide iodide	diarylmethane		low
mepenzolate bromide	diarylmethane		low
chlorphenoxamine	diarylmethane	anticoronaviral agent	low
chlorfenethol	diarylmethane		low
diphenadione	beta-triketone; diarylmethane		low
phenyltoloxamine	diarylmethane		low
n,n,n',n'-tetramethyl-4,4'-methylenedianiline	diarylmethane		low
diphenan	diarylmethane		low
diphenylmethane	diarylmethane		low
2,2'-methylenebis(4-methyl-6-tert-butylphenol)	diarylmethane		low
piperidolate hydrochloride	diarylmethane		low
benactyzine	diarylmethane		low
prenylamine	diarylmethane		low
isomethadone	diarylmethane		low
pipradrol	diarylmethane		low
normethadone	diarylmethane		low
captodiamine	diarylmethane		low
methadyl acetate	diarylmethane		low
benzomethamine	diarylmethane		low
chlorobenzilate	diarylmethane		low
dimenhydrinate	diarylmethane		low
poldine	diarylmethane		low
thiphenamil	diarylmethane		low
4-cumylphenol	diarylmethane		low
4,4'-bisphenol f	bisphenol; diarylmethane	environmental food contaminant; xenoestrogen	low
o,p'-ddt	diarylmethane		low
4,4'-methylene bis(2-methylaniline)	diarylmethane		low
dipipanone	diarylmethane		low
diphenamid	diarylmethane		low
paracymethadol	diarylmethane		low
bisphenol a-glycidyl methacrylate	diarylmethane		low
azacyclonol	diarylmethane		low
dimenoxadol	diarylmethane		low
amphenone b	diarylmethane		low
propinox	diarylmethane		low
embramine	diarylmethane		low
chlorophacinone	beta-triketone; diarylmethane		low
aminopentamide	diarylmethane		low
octocrylene	diarylmethane		low
terodiline	diarylmethane		low
tofenacin	diarylmethane		low
pipoxolan	diarylmethane		low
penfluridol	diarylmethane		low
emepronium	diarylmethane		low
levomethadyl acetate hydrochloride	diarylmethane		low
flumecinol	diarylmethane		low
setastine	diarylmethane		low
progabide	diarylmethane		low
beclobrate	diarylmethane		low
cetirizine dihydrochloride	diarylmethane		low
niguldipine	diarylmethane		low
terfenadine	diarylmethane		low
mandrax	diarylmethane		low
droprenylamine	diarylmethane		low
quifenadine	diarylmethane		low
carebastine	diarylmethane		low
lercanidipine	diarylmethane		low
diphenidol hydrochloride	diarylmethane		low
dioxadrol	diarylmethane		low
budipine	diarylmethane		low
epicainide	diarylmethane		low
butinoline	diarylmethane		low
denaverine	diarylmethane		low
lifarizine	diarylmethane		low
fenpiverinium	diarylmethane		low
2,2-methylenebis(4-chloro-3-methyl-isopropylphenol)	diarylmethane		low
amperozide	diarylmethane; monofluorobenzenes; N-alkylpiperazine; secondary carboxamide; ureas	anxiolytic drug; dopamine uptake inhibitor; geroprotector; second generation antipsychotic; serotonergic antagonist	low
2,2'-bisphenol f	diarylmethane		low
3-hydroxy-2,2-diphenylpropanoic acid	diarylmethane		low
1,1-Dichloro-2,2-bis(4-hydroxyphenyl)ethylene	diarylmethane		low
bisphenol f diglycidyl ether	aromatic ether; diarylmethane; epoxide		low
n-(4,4-diphenyl-3-butenyl)nipecotic acid	diarylmethane		low
methylene bis(methylanthranilate)	diarylmethane		low
tesmilifene	diarylmethane		low
pd 123177	diarylmethane		low
bw 373u86	diarylmethane		low
gilutensin hydrochloride	diarylmethane		low
4-(alpha-(4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl)-n,n-diethylbenzamide	diarylmethane		low
ae0047	diarylmethane		low
lercanidipine hydrochloride	diarylmethane		low
cloperastine hydrochloride	diarylmethane		low
1,1,1-trichloro-2-(4-hydroxyphenyl)-2-(4-methoxyphenyl)ethane	diarylmethane		low
2-[(4,6-dimethyl-2-pyrimidinyl)oxy]-3-methoxy-3,3-diphenylpropanoic acid	diarylmethane		low
ci 966	diarylmethane		low
Difeterol	diarylmethane		low
1,1-bis(4-hydroxyphenyl)cyclohexane	diarylmethane		low
2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene	diarylmethane		low
N-[2-(dimethylamino)ethyl]-2,2-diphenylacetamide	diarylmethane		low
propiverine hydrochloride	diarylmethane		low
gw 3965	diarylmethane		low
1,1-Bis(4-hydroxyphenyl)ethane	diarylmethane		low
uk 78282	diarylmethane		low
r 59949	diarylmethane		low
4-[1-(4-hydroxyphenyl)ethenyl]phenol	diarylmethane		low
5-[4-(diphenylmethyl)-1-piperazinyl]-2-(2-methoxyphenyl)-4-oxazolecarbonitrile	diarylmethane		low
flunarizine	diarylmethane		low
N-[4-[oxo-[(1-oxo-2,2-diphenylethyl)hydrazo]methyl]phenyl]propanamide	diarylmethane		low
[4-(diphenylmethyl)-1-piperazinyl]-[5-thiophen-2-yl-7-(trifluoromethyl)-3-pyrazolo[1,5-a]pyrimidinyl]methanone	diarylmethane		low
benztropine	diarylmethane		low
3-[[[(1-oxo-2,2-diphenylethyl)amino]-sulfanylidenemethyl]amino]benzoic acid	diarylmethane		low
3-bromo-5-[[4-[hydroxy(diphenyl)methyl]-1-piperidinyl]-oxomethyl]-2-pyranone	diarylmethane		low
2-(5-bromo-3-nitro-1,2,4-triazol-1-yl)-N-(diphenylmethyl)acetamide	diarylmethane		low
1,1-bis(4-chlorophenyl)-2-[(3-methoxyphenyl)methylamino]ethanol	diarylmethane		low
cinnarizine	diarylmethane; N-alkylpiperazine; olefinic compound	anti-allergic agent; antiemetic; calcium channel blocker; geroprotector; H1-receptor antagonist; histamine antagonist; muscarinic antagonist	low
levocetirizine	diarylmethane		low
amn082	benzenes; diamine; diarylmethane; secondary amino compound	metabotropic glutamate receptor agonist; neuroprotective agent	low
N-[2-[tert-butyl(methyl)amino]ethyl]-N-methyl-2,2-diphenylacetamide	diarylmethane		low
N-(4-fluorophenyl)-4-[hydroxy(diphenyl)methyl]-1-piperidinecarbothioamide	diarylmethane		low
4-oxo-3-[(1-oxo-2,2-diphenylethyl)amino]-2-sulfanylidene-1H-quinazoline-7-carboxylic acid methyl ester	diarylmethane		low
2,2-diphenylacetic acid (2,6-dimethylphenyl) ester	diarylmethane		low
1-ethyl-3-[(1-oxo-2,2-diphenylethyl)amino]thiourea	diarylmethane		low
2-(phenylmethyl)benzoic acid [2-[4-(difluoromethylthio)anilino]-2-oxoethyl] ester	diarylmethane		low
2-[2-[bis(4-methoxyphenyl)methylidene]hydrazinyl]benzoic acid	diarylmethane		low
N-[4-bromo-2-[[(2-hydrazinyl-2-oxoethyl)amino]-phenylmethyl]phenyl]-3-(4-morpholinyl)propanamide	diarylmethane		low
N-(4-ethoxyphenyl)-4-[hydroxy(diphenyl)methyl]-1-piperidinecarbothioamide	diarylmethane		low
4-[hydroxy(diphenyl)methyl]-N-(2-phenylethyl)-1-piperidinecarbothioamide	diarylmethane		low
3-(5-chloro-2-hydroxyphenyl)-3-phenyl-N-[(4-propan-2-yloxyphenyl)methyl]propanamide	diarylmethane		low
adrafinil	diarylmethane		low
zamifenacin	diarylmethane		low
2-(cyclohexylamino)-N-[(diphenylmethylene)amino]propanamide	diarylmethane		low
3-[[4-(diphenylmethyl)-1-piperazinyl]-oxomethyl]-7,8,9,10-tetrahydro-6H-azepino[2,1-b]quinazolin-12-one	diarylmethane		low
3-[bis(4-fluorophenyl)methoxy]-8-methyl-8-azabicyclo[3.2.1]octane	diarylmethane		low
flunarizine hydrochloride	diarylmethane		low
(2-amino-5-chlorophenyl)(phenyl)methanone oxime	diarylmethane		low
imidafenacin	diarylmethane		low
2-(3,3-diphenylpropylamino)acetamide	diarylmethane		low
cgk 733	diarylmethane		low
dexniguldipine	diarylmethane		low
lu 208075	diarylmethane		low
fesoterodine	diarylmethane		low
3-(diphenylmethylene)-1-[4-(4-phenyl-1-piperazinyl)butyl]pyrrolidine-2,5-dione	diarylmethane		low
pnu 200577	diarylmethane		low
gc 1 compound	diarylmethane		low
1,5-anhydro-1-(5-(4-ethoxybenzyl)-2-methoxy-4-methylphenyl)-1-thioglucitol	diarylmethane		low
[4-(diphenylmethyl)-1-piperazinyl]-(5-methyl-4-nitro-3-isoxazolyl)methanone	diarylmethane		low
1-(1,4-dioxan-2-yl)-N-[[3-(diphenylmethyl)-1,2,4-oxadiazol-5-yl]methyl]-N-methylmethanamine	diarylmethane		low
1-[4-(3-chlorophenyl)-1-piperazinyl]-3-(diphenylmethyl)oxy-2-propanol	diarylmethane		low
(8R)-3-[3-[[2-(4-chlorophenoxy)-1-oxoethyl]amino]phenyl]-7-(1-oxo-3,3-diphenylpropyl)-1-oxa-2,7-diazaspiro[4.4]non-2-ene-8-carboxamide	diarylmethane		low
3-(2-hydroxy-4,6-dimethoxyphenyl)-3-(4-methoxyphenyl)-1-(3-methyl-1-piperidinyl)-1-propanone	diarylmethane		low
2-[[[4-[[(diphenylmethyl)amino]-oxomethyl]-1H-imidazol-5-yl]-oxomethyl]amino]acetic acid tert-butyl ester	diarylmethane; tert-butyl ester		low
pf 04971729	diarylmethane		low
ML-210	C-nitro compound; diarylmethane; isoxazoles; monochlorobenzenes; N-acylpiperazine; N-alkylpiperazine; tertiary carboxamide	antineoplastic agent; EC 1.11.1.9 (glutathione peroxidase) inhibitor; ferroptosis inducer; prodrug	low

Substance	Studies	Classes	Roles	First Year	Last Year	Average Age	Relationship Strength	1990's
tetradecanoylphorbol acetate	1	acetate ester; diester; phorbol ester; tertiary alpha-hydroxy ketone; tetradecanoate ester	antineoplastic agent; apoptosis inducer; carcinogenic agent; mitogen; plant metabolite; protein kinase C agonist; reactive oxygen species generator	2000	2000	24.0	high	1
tranilast	1	amidobenzoic acid; cinnamamides; dimethoxybenzene; secondary carboxamide	anti-allergic agent; anti-asthmatic drug; antineoplastic agent; aryl hydrocarbon receptor agonist; calcium channel blocker; hepatoprotective agent; nephroprotective agent	1998	1998	26.0	high	1
transforming growth factor beta	1			2000	2000	24.0	high	1

Condition	Studies	First Year	Last Year	Average Age	Relationship Strength	1990's	2000's
Arterial Diseases, Carotid	1	2001	2001	23.0	medium	0	1
Carotid Artery Diseases	1	2001	2001	23.0	medium	0	1
Coronary Disease	1	2000	2000	24.0	medium	1	0
Coronary Heart Disease	1	2000	2000	24.0	medium	1	0
Recrudescence	1	2000	2000	24.0	medium	1	0

Bioavailability (2)

Article	Year
Highly stabilized amorphous 3-bis(4-methoxyphenyl)methylene-2-indolinone (TAS-301) in melt-adsorbed products with silicate compounds. Drug development and industrial pharmacy, , Volume: 29, Issue:5	2003
Improvement of solubility and oral bioavailability of a poorly water-soluble drug, TAS-301, by its melt-adsorption on a porous calcium silicate. Journal of pharmaceutical sciences, , Volume: 91, Issue:2	2002

Dosage (1)

Article	Year
Improvement of solubility and oral bioavailability of a poorly water-soluble drug, TAS-301, by its melt-adsorption on a porous calcium silicate. Journal of pharmaceutical sciences, , Volume: 91, Issue:2	2002