roseophilin

Description

roseophilin: isolated from Streptomyces griseovirdis; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	135408964
CHEMBL ID	2010153
SCHEMBL ID	1417359
MeSH ID	M0363683

Synonyms (6)

Synonym
NCI60_017647 ,
NEURO_000359
roseophilin
SCHEMBL1417359
CHEMBL2010153
Q7368629

Research Excerpts

Overview

Roseophilin is a unique metabolite containing two pyrrole and one furan ring. structurally related to tripyrrole antibiotics, prodigiosins.

Excerpt	Reference
"Roseophilin is a unique metabolite containing two pyrrole and one furan ring and is structurally related to tripyrrole antibiotics, prodigiosins. "	( A prodigiosin from the roseophilin producer Streptomyces griseoviridis. Hayakawa, Y; Kawasaki, T; Sakurai, F, 2008)

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (20)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	1 (5.00)	18.2507
2000's	12 (60.00)	29.6817
2010's	6 (30.00)	24.3611
2020's	1 (5.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	2 (10.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	18 (90.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
pyrroles 1H-pyrrole : A tautomer of pyrrole that has the double bonds at positions 2 and 4.. pyrrole : A five-membered monocyclic heteroarene comprising one NH and four CH units which forms the parent compound of the pyrrole group of compounds. Its five-membered ring structure has three tautomers. A 'closed class'.. azole : Any monocyclic heteroarene consisting of a five-membered ring containing nitrogen. Azoles can also contain one or more other non-carbon atoms, such as nitrogen, sulfur or oxygen.	6	20	pyrrole; secondary amine
cyclopentane Cyclopentanes: A group of alicyclic hydrocarbons with the general formula R-C5H9.. cyclopentanes : Cyclopentane and its derivatives formed by substitution.	2.43	2	cycloalkane; cyclopentanes; volatile organic compound	non-polar solvent
pyrrolnitrin Pyrrolnitrin: 3-Chloro-4-(3-chloro-2-nitrophenyl)pyrrole. Antifungal antibiotic isolated from Pseudomonas pyrrocinia. It is effective mainly against Trichophyton, Microsporium, Epidermophyton, and Penicillium.. pyrrolnitrin : A member of the class of pyrroles carrying chloro and 3-chloro-2-nitrophenyl substituents at positions 3 and 4 respectively.	3.27	1	alkaloid; C-nitro compound; monochlorobenzenes; pyrroles	antifungal drug; bacterial metabolite
scandium Scandium: An element of the rare earth family of metals. It has the atomic symbol Sc, atomic number 21, and atomic weight 45.	2.05	1	d-block element atom; rare earth metal atom; scandium group element atom
alkenes [no description available]	2.31	1
spirastrellolide f methyl ester spirastrellolide F methyl ester: structure in first source	2.31	1
heme Heme: The color-furnishing portion of hemoglobin. It is found free in tissues and as the prosthetic group in many hemeproteins.. ferroheme : Any iron(II)--porphyrin coordination complex.. ferroheme b : Heme b in which the iron has oxidation state +2.. heme : A heme is any tetrapyrrolic chelate of iron.	3.27	1
prodigiosin Prodigiosin: 4-Methoxy-5-((5-methyl-4-pentyl-2H-pyrrol-2-ylidene)methyl)- 2,2'-bi-1H-pyrrole. A toxic, bright red tripyrrole pigment from Serratia marcescens and others. It has antibacterial, anticoccidial, antimalarial, and antifungal activities, but is used mainly as a biochemical tool.. prodigiosin : A member of the class of tripyrroles that is a red-coloured pigment with antibiotic properties produced by Serratia marcescens.	5.15	8
butyl-meta-cycloheptylprodiginine butyl-meta-cycloheptylprodiginine: from actinomycete strain B 4358; structure given in first source	3.27	1
prodiginine prodiginine: prodigiosin-like pigments with antimicrobial & antimalarial activity; RN is from 9th CI; cpd not in Chemline 9/10/82	3.27	1
metacycloprodigiosin metacycloprodigiosin: a red pigment; produced by microbes including Streptomyces and Serratia	3.27	1
marineosin a marineosin A: cytotoxic spiroaminal from a marine-derived actinomycete; structure in first source. marineosin A : A macrocycle isolated from a marine sediment-derived actinomycete, Streptomyces sp. It exhibits cytotoxicity against colon tumour cell lines.	3.27	1	azaspiro compound; ether; macrocycle; oxaspiro compound; pyrroles	antineoplastic agent; metabolite

chemdatabank.com