Page last updated: 2024-10-15

marineosin a

Description

marineosin A: cytotoxic spiroaminal from a marine-derived actinomycete; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

marineosin A : A macrocycle isolated from a marine sediment-derived actinomycete, Streptomyces sp. It exhibits cytotoxicity against colon tumour cell lines. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID135960042
CHEMBL ID1221447
CHEBI ID66676
MeSH IDM0538508

Synonyms (5)

Synonym
marineosin a
chebi:66676 ,
CHEMBL1221447
(1r,3s,3'r,4as,15as)-3'-methoxy-3-methyl-5'-(1h-pyrrol-2-yl)-3',4,4',4a,5,6,7,8,9,10,11,15a-dodecahydro-3h-spiro[12,15-epiminocyclotrideca[c]pyran-1,2'-pyrrole]
Q27135296
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (2)

RoleDescription
metaboliteAny intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.
antineoplastic agentA substance that inhibits or prevents the proliferation of neoplasms.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (5)

ClassDescription
azaspiro compoundAn azaspiro compound is a spiro compound in which at least one of the cyclic components is a nitrogen heterocyle.
oxaspiro compoundA spiro compound in which at least one of the cyclic components is an oxygen heterocyle.
etherAn organooxygen compound with formula ROR, where R is not hydrogen.
pyrrolesAn azole that includes only one N atom and no other heteroatom as a part of the aromatic skeleton.
macrocycleA cyclic compound containing nine or more atoms as part of the cyclic system.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (2)

Assay IDTitleYearJournalArticle
AID501424Antiproliferative activity against human HCT116 cells after 48 hrs by WST-1 assay2010Bioorganic & medicinal chemistry letters, Sep-01, Volume: 20, Issue:17
Total synthesis and biological evaluation of tambjamine K and a library of unnatural analogs.
AID501425Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by WST-1 assay2010Bioorganic & medicinal chemistry letters, Sep-01, Volume: 20, Issue:17
Total synthesis and biological evaluation of tambjamine K and a library of unnatural analogs.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (12.50)29.6817
2010's7 (87.50)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (12.50%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other7 (87.50%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]