Page last updated: 2024-12-10

rgh 0205

Description

RGH 0205: RN given refers to all (L)-isomer [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Synonym
thymotrinanum [inn-latin]
arg-lys-asp
thymotrinan [inn]
arginyl-lysyl-aspartic acid
timotrinan [inn-spanish]
l-aspartic acid, n-(n(sup 2)-l-arginyl-l-lysyl)-
rgh 0205
n-(n(sup 2)-l-arginyl-l-lysyl)-l-aspartic acid
rgh-0205
thymotrinan
85465-82-3
CHEBI:159125
(2s)-2-[[(2s)-6-amino-2-[[(2s)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]butanedioic acid
CHEMBL2105488
thymotrinanum
timotrinan
unii-29oe04a6c9
29oe04a6c9 ,
SCHEMBL62515
DTXSID60234687
SCHEMBL15532089
thymopoietin ii (32-34)
(s)-2-((s)-6-amino-2-((s)-2-amino-5-guanidinopentanamido)hexanamido)succinic acid
l-arginyl-l-lysyl-l-aspartic acid
rgh 0205; tp 3
Q27254434
HY-106765
CS-0026503
AKOS040754202

Excerpt	Reference	Relevance
" toxicity test on Wobe:BEAGLE dogs given daily doses of 6, 20 and 60 mg/kg of either test compound, no adverse reaction occurred."	( Preclinical toxicity studies with two thymopoietin-like peptides. Bodrogligeti, I; Cholnoky, E; Iván, E; Juhász-Nagy, A; Német, L, 1985)	0.27

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Class	Description
oligopeptide	A peptide containing a relatively small number of amino acids.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	5 (83.33)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (16.67)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	6 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
diazepam Diazepam: A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity.. diazepam : A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a chloro group at position 7, a methyl group at position 1 and a phenyl group at position 5.	1.97	1	1,4-benzodiazepinone; organochlorine compound	anticonvulsant; anxiolytic drug; environmental contaminant; sedative; xenobiotic
mannitol [no description available]	2	1	mannitol	allergen; antiglaucoma drug; compatible osmolytes; Escherichia coli metabolite; food anticaking agent; food bulking agent; food humectant; food stabiliser; food thickening agent; hapten; metabolite; osmotic diuretic; sweetening agent
thymopentin Thymopentin: Synthetic pentapeptide corresponding to the amino acids 32-36 of thymopoietin and exhibiting the full biological activity of the natural hormone. It is an immunomodulator which has been studied for possible use in the treatment of rheumatoid arthritis, AIDS, and other primary immunodeficiencies.	2.66	3	oligopeptide
oxazolone Oxazolone: Immunologic adjuvant and sensitizing agent.	1.96	1
thymocartin [no description available]	2.89	4

Condition	Relationship Strength	Studies
Delayed Hypersensitivity [description not available]	1.96	1
Acute Liver Injury, Drug-Induced [description not available]	1.96	1
Eye Disorders [description not available]	1.96	1
Blood Diseases [description not available]	1.96	1
Nervous System Disorders [description not available]	1.96	1
Eye Diseases Diseases affecting the eye.	1.96	1
Hematologic Diseases Disorders of the blood and blood forming tissues.	1.96	1
Kidney Diseases Pathological processes of the KIDNEY or its component tissues.	1.96	1
Nervous System Diseases Diseases of the central and peripheral nervous system. This includes disorders of the brain, spinal cord, cranial nerves, peripheral nerves, nerve roots, autonomic nervous system, neuromuscular junction, and muscle.	1.96	1
Chemical and Drug Induced Liver Injury A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.	1.96	1