Compounds > praelolide
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praelolide

Description

praelolide: diterpene lactone from gorgonian Menella praelonga; molecular formula C28-H35-O12-Cl; structure given in first source [MeSH]

Cross-References

ID SourceID
PubMed CID14264086
CHEMBL ID500581
MeSH IDM0142032

Synonyms (3)

Synonym
praelolide
CHEMBL500581
[(1r,2s,3s,4r,7s,8r,9r,10s,11s,13s,14r,17r)-2,9,10-triacetyloxy-13-chloro-8,17-dimethyl-12-methylidene-16-oxospiro[15,18-dioxatetracyclo[9.6.1.01,14.03,8]octadecane-4,2'-oxirane]-7-yl] acetate

Bioassays (10)

Assay IDTitleYearJournalArticle
AID666774Antibacterial activity against Escherichia coli at 2 mg/ml by agar diffusion test2012Bioorganic & medicinal chemistry letters, Jul-01, Volume: 22, Issue:13
ISSN: 1464-3405		Bioactive briarane diterpenoids from the South China Sea gorgonian Dichotella gemmacea.
AID378376Cytotoxicity against mouse P388 cells1999Journal of natural products, Feb, Volume: 62, Issue:2
ISSN: 1520-6025		Absolute structures of new briarane diterpenoids from junceella fragilis
AID666773Cytotoxicity against human MG63 cells by MTT assay2012Bioorganic & medicinal chemistry letters, Jul-01, Volume: 22, Issue:13
ISSN: 1464-3405		Bioactive briarane diterpenoids from the South China Sea gorgonian Dichotella gemmacea.
AID378377Cytotoxicity against human A549 cells1999Journal of natural products, Feb, Volume: 62, Issue:2
ISSN: 1520-6025		Absolute structures of new briarane diterpenoids from junceella fragilis
AID666772Cytotoxicity against human A549 cells by MTT assay2012Bioorganic & medicinal chemistry letters, Jul-01, Volume: 22, Issue:13
ISSN: 1464-3405		Bioactive briarane diterpenoids from the South China Sea gorgonian Dichotella gemmacea.
AID666777Antifungal activity against Septoria tritici at 2 mg/ml by agar diffusion test2012Bioorganic & medicinal chemistry letters, Jul-01, Volume: 22, Issue:13
ISSN: 1464-3405		Bioactive briarane diterpenoids from the South China Sea gorgonian Dichotella gemmacea.
AID666776Antifungal activity against Microbotryum violaceum at 2 mg/ml by agar diffusion test2012Bioorganic & medicinal chemistry letters, Jul-01, Volume: 22, Issue:13
ISSN: 1464-3405		Bioactive briarane diterpenoids from the South China Sea gorgonian Dichotella gemmacea.
AID378379Cytotoxicity against human SK MEL28 cells1999Journal of natural products, Feb, Volume: 62, Issue:2
ISSN: 1520-6025		Absolute structures of new briarane diterpenoids from junceella fragilis
AID666775Antibacterial activity against Bacillus megaterium at 2 mg/ml by agar diffusion test2012Bioorganic & medicinal chemistry letters, Jul-01, Volume: 22, Issue:13
ISSN: 1464-3405		Bioactive briarane diterpenoids from the South China Sea gorgonian Dichotella gemmacea.
AID378378Cytotoxicity against human HT-29 cells1999Journal of natural products, Feb, Volume: 62, Issue:2
ISSN: 1520-6025		Absolute structures of new briarane diterpenoids from junceella fragilis

Research

Studies (8)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (12.50)18.7374
1990's2 (25.00)18.2507
2000's2 (25.00)29.6817
2010's2 (25.00)24.3611
2020's1 (12.50)2.80

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other8 (100.00%)84.16%
SubstanceStudiesClassesRolesFirst YearLast YearAverage AgeRelationship StrengthTrialspre-19901990's2000's2010'spost-2020
ketoconazole
1
dichlorobenzene;
dioxolane;
ether;
imidazoles;
N-acylpiperazine;
N-arylpiperazine		2012201212.0medium000010
penicillin g
1
penicillin allergen;
penicillin		antibacterial drug;
drug allergen;
epitope		2012201212.0medium000010
streptomycin
1
antibiotic antifungal drug;
antibiotic fungicide;
streptomycins		antibacterial drug;
antifungal agrochemical;
antimicrobial agent;
antimicrobial drug;
bacterial metabolite;
protein synthesis inhibitor		2012201212.0medium000010
SubstanceStudiesClassesRolesFirst YearLast YearAverage AgeRelationship StrengthTrialspre-19901990's2000's2010'spost-2020
junceellin
3
1998200422.3high001200
ConditionIndicatedStudiesFirst YearLast YearAverage AgeRelationship StrengthTrialspre-19901990's2000's2010'spost-2020
Leukemia P3880
1
2003200321.0high000100