Page last updated: 2024-11-12
praelolide
Description
Research Excerpts
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Description
praelolide: diterpene lactone from gorgonian Menella praelonga; molecular formula C28-H35-O12-Cl; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
| ID Source | ID |
|---|---|
| PubMed CID | 14264086 |
| CHEMBL ID | 500581 |
| MeSH ID | M0142032 |
Synonyms (3)
| Synonym |
|---|
| praelolide |
| CHEMBL500581 |
| [(1r,2s,3s,4r,7s,8r,9r,10s,11s,13s,14r,17r)-2,9,10-triacetyloxy-13-chloro-8,17-dimethyl-12-methylidene-16-oxospiro[15,18-dioxatetracyclo[9.6.1.01,14.03,8]octadecane-4,2'-oxirane]-7-yl] acetate |
Research Excerpts
Overview
Praelolide is a new compound which was isolated out from the gorgonian, Menella praelonga (Ridley), collected from the South Sea of China at Zhanjiang, Guangdong.
| Excerpt | Reference | Relevance |
|---|---|---|
| "Praelolide is a new compound which was isolated out from the gorgonian, Menella praelonga (Ridley), collected from the South Sea of China at Zhanjiang, Guangdong. " | ( Molecular structure and absolute configuration of the diterpene lactone, praelolide. Dai, JB; Fang, Z; Liang, DC; Long, KH; Luo, YK; Rao, ZH; Wan, ZL, 1985) | 1.94 |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Bioassays (10)
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID666774 | Antibacterial activity against Escherichia coli at 2 mg/ml by agar diffusion test | 2012 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 22, Issue:13 | Bioactive briarane diterpenoids from the South China Sea gorgonian Dichotella gemmacea. |
| AID378376 | Cytotoxicity against mouse P388 cells | 1999 | Journal of natural products, Feb, Volume: 62, Issue:2 | Absolute structures of new briarane diterpenoids from junceella fragilis |
| AID666773 | Cytotoxicity against human MG63 cells by MTT assay | 2012 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 22, Issue:13 | Bioactive briarane diterpenoids from the South China Sea gorgonian Dichotella gemmacea. |
| AID378377 | Cytotoxicity against human A549 cells | 1999 | Journal of natural products, Feb, Volume: 62, Issue:2 | Absolute structures of new briarane diterpenoids from junceella fragilis |
| AID666772 | Cytotoxicity against human A549 cells by MTT assay | 2012 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 22, Issue:13 | Bioactive briarane diterpenoids from the South China Sea gorgonian Dichotella gemmacea. |
| AID666777 | Antifungal activity against Septoria tritici at 2 mg/ml by agar diffusion test | 2012 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 22, Issue:13 | Bioactive briarane diterpenoids from the South China Sea gorgonian Dichotella gemmacea. |
| AID666776 | Antifungal activity against Microbotryum violaceum at 2 mg/ml by agar diffusion test | 2012 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 22, Issue:13 | Bioactive briarane diterpenoids from the South China Sea gorgonian Dichotella gemmacea. |
| AID378379 | Cytotoxicity against human SK MEL28 cells | 1999 | Journal of natural products, Feb, Volume: 62, Issue:2 | Absolute structures of new briarane diterpenoids from junceella fragilis |
| AID666775 | Antibacterial activity against Bacillus megaterium at 2 mg/ml by agar diffusion test | 2012 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 22, Issue:13 | Bioactive briarane diterpenoids from the South China Sea gorgonian Dichotella gemmacea. |
| AID378378 | Cytotoxicity against human HT-29 cells | 1999 | Journal of natural products, Feb, Volume: 62, Issue:2 | Absolute structures of new briarane diterpenoids from junceella fragilis |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
Research
Studies (8)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 1 (12.50) | 18.7374 |
| 1990's | 2 (25.00) | 18.2507 |
| 2000's | 2 (25.00) | 29.6817 |
| 2010's | 2 (25.00) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 8 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||