Compounds > praelolide
Page last updated: 2024-11-12

praelolide

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

praelolide: diterpene lactone from gorgonian Menella praelonga; molecular formula C28-H35-O12-Cl; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID14264086
CHEMBL ID500581
MeSH IDM0142032

Synonyms (3)

Synonym
praelolide
CHEMBL500581
[(1r,2s,3s,4r,7s,8r,9r,10s,11s,13s,14r,17r)-2,9,10-triacetyloxy-13-chloro-8,17-dimethyl-12-methylidene-16-oxospiro[15,18-dioxatetracyclo[9.6.1.01,14.03,8]octadecane-4,2'-oxirane]-7-yl] acetate

Research Excerpts

Overview

Praelolide is a new compound which was isolated out from the gorgonian, Menella praelonga (Ridley), collected from the South Sea of China at Zhanjiang, Guangdong.

ExcerptReferenceRelevance
"Praelolide is a new compound which was isolated out from the gorgonian, Menella praelonga (Ridley), collected from the South Sea of China at Zhanjiang, Guangdong. "( Molecular structure and absolute configuration of the diterpene lactone, praelolide.
Dai, JB; Fang, Z; Liang, DC; Long, KH; Luo, YK; Rao, ZH; Wan, ZL, 1985)		1.94
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (10)

Assay IDTitleYearJournalArticle
AID666774Antibacterial activity against Escherichia coli at 2 mg/ml by agar diffusion test2012Bioorganic & medicinal chemistry letters, Jul-01, Volume: 22, Issue:13
Bioactive briarane diterpenoids from the South China Sea gorgonian Dichotella gemmacea.
AID378376Cytotoxicity against mouse P388 cells1999Journal of natural products, Feb, Volume: 62, Issue:2
Absolute structures of new briarane diterpenoids from junceella fragilis
AID666773Cytotoxicity against human MG63 cells by MTT assay2012Bioorganic & medicinal chemistry letters, Jul-01, Volume: 22, Issue:13
Bioactive briarane diterpenoids from the South China Sea gorgonian Dichotella gemmacea.
AID378377Cytotoxicity against human A549 cells1999Journal of natural products, Feb, Volume: 62, Issue:2
Absolute structures of new briarane diterpenoids from junceella fragilis
AID666772Cytotoxicity against human A549 cells by MTT assay2012Bioorganic & medicinal chemistry letters, Jul-01, Volume: 22, Issue:13
Bioactive briarane diterpenoids from the South China Sea gorgonian Dichotella gemmacea.
AID666777Antifungal activity against Septoria tritici at 2 mg/ml by agar diffusion test2012Bioorganic & medicinal chemistry letters, Jul-01, Volume: 22, Issue:13
Bioactive briarane diterpenoids from the South China Sea gorgonian Dichotella gemmacea.
AID666776Antifungal activity against Microbotryum violaceum at 2 mg/ml by agar diffusion test2012Bioorganic & medicinal chemistry letters, Jul-01, Volume: 22, Issue:13
Bioactive briarane diterpenoids from the South China Sea gorgonian Dichotella gemmacea.
AID378379Cytotoxicity against human SK MEL28 cells1999Journal of natural products, Feb, Volume: 62, Issue:2
Absolute structures of new briarane diterpenoids from junceella fragilis
AID666775Antibacterial activity against Bacillus megaterium at 2 mg/ml by agar diffusion test2012Bioorganic & medicinal chemistry letters, Jul-01, Volume: 22, Issue:13
Bioactive briarane diterpenoids from the South China Sea gorgonian Dichotella gemmacea.
AID378378Cytotoxicity against human HT-29 cells1999Journal of natural products, Feb, Volume: 62, Issue:2
Absolute structures of new briarane diterpenoids from junceella fragilis
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (12.50)18.7374
1990's2 (25.00)18.2507
2000's2 (25.00)29.6817
2010's2 (25.00)24.3611
2020's1 (12.50)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other8 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
ketoconazole
1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine : A dioxolane that is 1,3-dioxolane which is substituted at positions 2, 2, and 4 by imidazol-1-ylmethyl, 2,4-dichlorophenyl, and [para-(4-acetylpiperazin-1-yl)phenoxy]methyl groups, respectively.		2.0710dichlorobenzene;
dioxolane;
ether;
imidazoles;
N-acylpiperazine;
N-arylpiperazine
penicillin g
Penicillin G: A penicillin derivative commonly used in the form of its sodium or potassium salts in the treatment of a variety of infections. It is effective against most gram-positive bacteria and against gram-negative cocci. It has also been used as an experimental convulsant because of its actions on GAMMA-AMINOBUTYRIC ACID mediated synaptic transmission.. benzylpenicillin : A penicillin in which the substituent at position 6 of the penam ring is a phenylacetamido group.		2.0710penicillin allergen;
penicillin		antibacterial drug;
drug allergen;
epitope
streptomycin
[no description available]		2.0710antibiotic antifungal drug;
antibiotic fungicide;
streptomycins		antibacterial drug;
antifungal agrochemical;
antimicrobial agent;
antimicrobial drug;
bacterial metabolite;
protein synthesis inhibitor
junceellin
junceellin: from gorgonian, Gorgonella umbraculum; structure in first source		2.730
ConditionIndicatedRelationship StrengthStudiesTrials
Leukemia P388
An experimental lymphocytic leukemia originally induced in DBA/2 mice by painting with methylcholanthrene.		02.0110