Page last updated: 2024-12-10
nsc73306
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
Related Conditions
Protein Interactions
Research Growth
Cross-References
ID Source | ID |
---|---|
PubMed CID | 3003794 |
SCHEMBL ID | 14075836 |
SCHEMBL ID | 469855 |
MeSH ID | M0499348 |
Synonyms (20)
Synonym |
---|
NCI60_041604 |
NCIMECH_000014 , |
79560-74-0 |
nsc-73304 |
NSC73306 , |
nsc73304 |
1-[(z)-(5,7-dichloro-2-oxo-indolin-3-ylidene)amino]-3-(4-methoxyphenyl)thiourea |
5,7-dichloro-1h-indole-2,3-dione 3-(n-(4-methoxyphenyl)thiosemicarbazone) |
NCIOPEN2_008732 |
AKOS000963121 |
CCG-35327 |
SCHEMBL14075836 |
SCHEMBL469855 |
DTXSID70417681 |
G3GZ237PUT , |
2-(5,7-dichloro-1,2-dihydro-2-oxo-3h-indol-3-ylidene)-n-(4-methoxyphenyl)hydrazinecarbothioamide |
1043426-80-7 |
hydrazinecarbothioamide, 2-(5,7-dichloro-1,2-dihydro-2-oxo-3h-indol-3-ylidene)-n-(4-methoxyphenyl)- |
unii-g3gz237put |
874650-89-2 |
Research Excerpts
Overview
NSC73306 is a thiosemicarbazone compound that displays greater toxicity against cells expressing functional P-gp than against other cells.
Excerpt | Reference | Relevance |
---|---|---|
"NSC73306 is a thiosemicarbazone compound that displays greater toxicity against cells expressing functional P-gp than against other cells." | ( Uptake of compounds that selectively kill multidrug-resistant cells: the copper transporter SLC31A1 (CTR1) increases cellular accumulation of the thiosemicarbazone NSC73306. Fung, KL; Gottesman, MM; Hall, MD; Pixley, JN; Pluchino, KM; Pouliot, LM; Tepede, AK, 2014) | 1.32 |
Dosage Studied
Excerpt | Relevance | Reference |
---|---|---|
" TSC-H, TSC-F, and TSC-Cl exhibited a bell-shaped dose-response curve for the induction of apoptosis in K562 cells due to the change from apoptosis to necrosis as the principal mechanism of cell death at the highest tested doses." | ( Thiosemicarbazone p-Substituted Acetophenone Derivatives Promote the Loss of Mitochondrial Δψ, GSH Depletion, and Death in K562 Cells. Basso, EA; Fernandes, CS; Kaiser, CR; Nantes, IL; Pessoto, FS; Prieto, T; Silva, AP; Yokomizo, CH, 2015) | 0.42 |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Research
Studies (6)
Timeframe | Studies, This Drug (%) | All Drugs % |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 3 (50.00) | 29.6817 |
2010's | 3 (50.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Study Types
Publication Type | This drug (%) | All Drugs (%) |
---|---|---|
Trials | 0 (0.00%) | 5.53% |
Reviews | 0 (0.00%) | 6.00% |
Case Studies | 0 (0.00%) | 4.05% |
Observational | 0 (0.00%) | 0.25% |
Other | 6 (100.00%) | 84.16% |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |