Compounds > notoamide b

Page last updated: 2024-11-12

notoamide b

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

notoamide B: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	16127923
CHEMBL ID	2042022
MeSH ID	M0510811

Synonyms (6)

Synonym
(-)-notoamide b
CHEMBL2042022
notoamide b
(1's,3r,7's,9's)-7,7,10',10'-tetramethylspiro[1h-pyrano[2,3-g]indole-3,11'-3,13-diazatetracyclo[5.5.2.01,9.03,7]tetradecane]-2,2',14'-trione
937791-52-1
DTXSID801046203

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (14)

Assay ID	Title	Year	Journal	Article
AID667073	Antifungal activity against Candida albicans DAY185 assessed as inhibition of biofilm formation after 48 hrs by XTT assay	2012	Journal of natural products, Apr-27, Volume: 75, Issue:4	Waikialoid A suppresses hyphal morphogenesis and inhibits biofilm development in pathogenic Candida albicans.
AID735803	Cytotoxicity against human HL60 cells assessed as inhibition of cell viability by MTT assay	2013	Journal of natural products, Apr-26, Volume: 76, Issue:4	Bioactive indole alkaloids and phenyl ether derivatives from a marine-derived Aspergillus sp. Fungus.
AID1634821	Activation of Escherichia coli BLR (DE3) ClpP using bovine milk FITC-beta casein as substrate assessed as change in relative fluorescent units at 50 uM preincubated for 15 mins followed by substrate addition measured every 30 mins for 6 hrs by fluorescenc	2016	Journal of natural products, Apr-22, Volume: 79, Issue:4	Sclerotiamide: The First Non-Peptide-Based Natural Product Activator of Bacterial Caseinolytic Protease P.
AID735808	Antibacterial activity against Vibrio anguillarum ATCC 19019 assessed as growth inhibition	2013	Journal of natural products, Apr-26, Volume: 76, Issue:4	Bioactive indole alkaloids and phenyl ether derivatives from a marine-derived Aspergillus sp. Fungus.
AID735809	Antibacterial activity against Escherichia coli ATCC 25922 assessed as growth inhibition	2013	Journal of natural products, Apr-26, Volume: 76, Issue:4	Bioactive indole alkaloids and phenyl ether derivatives from a marine-derived Aspergillus sp. Fungus.
AID735813	Antibacterial activity against Bacillus cereus ACCC 11077 assessed as growth inhibition	2013	Journal of natural products, Apr-26, Volume: 76, Issue:4	Bioactive indole alkaloids and phenyl ether derivatives from a marine-derived Aspergillus sp. Fungus.
AID735811	Antibacterial activity against Staphylococcus epidermidis ATCC 12228 assessed as growth inhibition	2013	Journal of natural products, Apr-26, Volume: 76, Issue:4	Bioactive indole alkaloids and phenyl ether derivatives from a marine-derived Aspergillus sp. Fungus.
AID735807	Antibacterial activity against Vibrio parahaemolyticus ATCC 17802 assessed as growth inhibition	2013	Journal of natural products, Apr-26, Volume: 76, Issue:4	Bioactive indole alkaloids and phenyl ether derivatives from a marine-derived Aspergillus sp. Fungus.
AID735806	Antibacterial activity against Pseudomonas putida ATCC 17848 assessed as growth inhibition	2013	Journal of natural products, Apr-26, Volume: 76, Issue:4	Bioactive indole alkaloids and phenyl ether derivatives from a marine-derived Aspergillus sp. Fungus.
AID1465315	Inhibition of RANKL-induced formation of multinuclear osteoclasts in mouse RAW264 cells at 10 ug/ml after 4 days by p-NPP substrate based absorbance method	2017	Bioorganic & medicinal chemistry letters, 11-15, Volume: 27, Issue:22	Enantioselective inhibitory abilities of enantiomers of notoamides against RANKL-induced formation of multinuclear osteoclasts.
AID735810	Antibacterial activity against Staphylococcus aureus ATCC 27154 assessed as growth inhibition	2013	Journal of natural products, Apr-26, Volume: 76, Issue:4	Bioactive indole alkaloids and phenyl ether derivatives from a marine-derived Aspergillus sp. Fungus.
AID667072	Antifungal activity against Candida albicans DAY185 assessed as lowest compound concentration causing =>80% reduction in cell viability after 48 hrs by XTT assay	2012	Journal of natural products, Apr-27, Volume: 75, Issue:4	Waikialoid A suppresses hyphal morphogenesis and inhibits biofilm development in pathogenic Candida albicans.
AID735812	Antibacterial activity against Micrococcus tetragenus ATCC 13623 assessed as growth inhibition	2013	Journal of natural products, Apr-26, Volume: 76, Issue:4	Bioactive indole alkaloids and phenyl ether derivatives from a marine-derived Aspergillus sp. Fungus.
AID735804	Cytotoxicity against human K562 cells assessed as inhibition of cell viability by MTT assay	2013	Journal of natural products, Apr-26, Volume: 76, Issue:4	Bioactive indole alkaloids and phenyl ether derivatives from a marine-derived Aspergillus sp. Fungus.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (14)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	3 (21.43)	29.6817
2010's	10 (71.43)	24.3611
2020's	1 (7.14)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.12

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	12.12 (24.57)
Research Supply Index	2.71 (2.92)
Research Growth Index	4.83 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (12.12)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	1 (7.14%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	13 (92.86%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
ciprofloxacin Ciprofloxacin: A broad-spectrum antimicrobial carboxyfluoroquinoline.. ciprofloxacin : A quinolone that is quinolin-4(1H)-one bearing cyclopropyl, carboxylic acid, fluoro and piperazin-1-yl substituents at positions 1, 3, 6 and 7, respectively.	2.08	1	0	aminoquinoline; cyclopropanes; fluoroquinolone antibiotic; N-arylpiperazine; quinolinemonocarboxylic acid; quinolone antibiotic; quinolone; zwitterion	antibacterial drug; antiinfective agent; antimicrobial agent; DNA synthesis inhibitor; EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor; environmental contaminant; topoisomerase IV inhibitor; xenobiotic
farnesol Farnesol: A colorless liquid extracted from oils of plants such as citronella, neroli, cyclamen, and tuberose. It is an intermediate step in the biological synthesis of cholesterol from mevalonic acid in vertebrates. It has a delicate odor and is used in perfumery. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed). (2-trans,6-trans)-farnesol : The (2-trans,6-trans)-stereoisomer of farnesol.. farnesol : A farnesane sesquiterpenoid that is dodeca-2,6,10-triene substituted by methyl groups at positions 3, 7 and 11 and a hydroxy group at position 1.	2.07	1	0	farnesol	plant metabolite
stephacidin a stephacidin A: from Aspergillus ochraceus; structure in first source	4.67	8	0
sclerotiamide sclerotiamide: related to the paraherquamides; isolated from the sclerotia of Aspergillus sclerotiorum; structure given in first source	7.78	3	0
avrainvillamide avrainvillamide: from Aspergillus sp.; structure in first source	2.07	1	0	1-benzopyran
diorcinol diorcinol : An aromatic ether that is diphenyl ether in which both phenyl groups are substituted at position 3 by a hydroxy group and at position 5 by a methyl group.	2.08	1	0	aromatic ether; phenols	fungal metabolite; marine metabolite; metabolite
versicolamide b versicolamide B: isolated from Aspergillus versicolor; structure in first source	7.75	3	0
stephacidin b stephacidin B: from Aspergillus ochraceus; structure in first source	2.03	1	0