Page last updated: 2024-11-12

notoamide b

Description

notoamide B: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID16127923
CHEMBL ID2042022
MeSH IDM0510811

Synonyms (6)

Synonym
(-)-notoamide b
CHEMBL2042022
notoamide b
(1's,3r,7's,9's)-7,7,10',10'-tetramethylspiro[1h-pyrano[2,3-g]indole-3,11'-3,13-diazatetracyclo[5.5.2.01,9.03,7]tetradecane]-2,2',14'-trione
937791-52-1
DTXSID801046203
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (14)

Assay IDTitleYearJournalArticle
AID667073Antifungal activity against Candida albicans DAY185 assessed as inhibition of biofilm formation after 48 hrs by XTT assay2012Journal of natural products, Apr-27, Volume: 75, Issue:4
Waikialoid A suppresses hyphal morphogenesis and inhibits biofilm development in pathogenic Candida albicans.
AID735803Cytotoxicity against human HL60 cells assessed as inhibition of cell viability by MTT assay2013Journal of natural products, Apr-26, Volume: 76, Issue:4
Bioactive indole alkaloids and phenyl ether derivatives from a marine-derived Aspergillus sp. Fungus.
AID1634821Activation of Escherichia coli BLR (DE3) ClpP using bovine milk FITC-beta casein as substrate assessed as change in relative fluorescent units at 50 uM preincubated for 15 mins followed by substrate addition measured every 30 mins for 6 hrs by fluorescenc2016Journal of natural products, Apr-22, Volume: 79, Issue:4
Sclerotiamide: The First Non-Peptide-Based Natural Product Activator of Bacterial Caseinolytic Protease P.
AID735808Antibacterial activity against Vibrio anguillarum ATCC 19019 assessed as growth inhibition2013Journal of natural products, Apr-26, Volume: 76, Issue:4
Bioactive indole alkaloids and phenyl ether derivatives from a marine-derived Aspergillus sp. Fungus.
AID735809Antibacterial activity against Escherichia coli ATCC 25922 assessed as growth inhibition2013Journal of natural products, Apr-26, Volume: 76, Issue:4
Bioactive indole alkaloids and phenyl ether derivatives from a marine-derived Aspergillus sp. Fungus.
AID735813Antibacterial activity against Bacillus cereus ACCC 11077 assessed as growth inhibition2013Journal of natural products, Apr-26, Volume: 76, Issue:4
Bioactive indole alkaloids and phenyl ether derivatives from a marine-derived Aspergillus sp. Fungus.
AID735811Antibacterial activity against Staphylococcus epidermidis ATCC 12228 assessed as growth inhibition2013Journal of natural products, Apr-26, Volume: 76, Issue:4
Bioactive indole alkaloids and phenyl ether derivatives from a marine-derived Aspergillus sp. Fungus.
AID735807Antibacterial activity against Vibrio parahaemolyticus ATCC 17802 assessed as growth inhibition2013Journal of natural products, Apr-26, Volume: 76, Issue:4
Bioactive indole alkaloids and phenyl ether derivatives from a marine-derived Aspergillus sp. Fungus.
AID735806Antibacterial activity against Pseudomonas putida ATCC 17848 assessed as growth inhibition2013Journal of natural products, Apr-26, Volume: 76, Issue:4
Bioactive indole alkaloids and phenyl ether derivatives from a marine-derived Aspergillus sp. Fungus.
AID1465315Inhibition of RANKL-induced formation of multinuclear osteoclasts in mouse RAW264 cells at 10 ug/ml after 4 days by p-NPP substrate based absorbance method2017Bioorganic & medicinal chemistry letters, 11-15, Volume: 27, Issue:22
Enantioselective inhibitory abilities of enantiomers of notoamides against RANKL-induced formation of multinuclear osteoclasts.
AID735810Antibacterial activity against Staphylococcus aureus ATCC 27154 assessed as growth inhibition2013Journal of natural products, Apr-26, Volume: 76, Issue:4
Bioactive indole alkaloids and phenyl ether derivatives from a marine-derived Aspergillus sp. Fungus.
AID667072Antifungal activity against Candida albicans DAY185 assessed as lowest compound concentration causing =>80% reduction in cell viability after 48 hrs by XTT assay2012Journal of natural products, Apr-27, Volume: 75, Issue:4
Waikialoid A suppresses hyphal morphogenesis and inhibits biofilm development in pathogenic Candida albicans.
AID735812Antibacterial activity against Micrococcus tetragenus ATCC 13623 assessed as growth inhibition2013Journal of natural products, Apr-26, Volume: 76, Issue:4
Bioactive indole alkaloids and phenyl ether derivatives from a marine-derived Aspergillus sp. Fungus.
AID735804Cytotoxicity against human K562 cells assessed as inhibition of cell viability by MTT assay2013Journal of natural products, Apr-26, Volume: 76, Issue:4
Bioactive indole alkaloids and phenyl ether derivatives from a marine-derived Aspergillus sp. Fungus.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (14)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (21.43)29.6817
2010's10 (71.43)24.3611
2020's1 (7.14)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.12

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.12 (24.57)
Research Supply Index2.71 (2.92)
Research Growth Index4.83 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.12)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (7.14%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other13 (92.86%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
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