Compounds > myrocin a
Page last updated: 2024-11-12

myrocin a

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

myrocin A: secondary metabolite from the marine endophytic fungus Apiospora montagnei; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID11394232
CHEMBL ID516554
CHEBI ID68199
MeSH IDM0470445

Synonyms (9)

Synonym
myrocin a
CHEMBL516554
chebi:68199 ,
(1r,2r,5s,11r,14r)-5-ethenyl-2,9-dihydroxy-5,11-dimethyl-3,8-dioxotetracyclo[8.5.0.01,14.02,7]pentadeca-6,9-diene-11-carboxylic acid
NCGC00380725-01
ncgc00380725-01_c20h22o6_cyclopropa[d]phenanthrene-3-carboxylic acid, 7-ethenyl-1,2,3,5,7,8,9,9a,10,10a-decahydro-4,9a-dihydroxy-3,7-dimethyl-5,9-dioxo-, (3r,7s,9ar,9br,10ar)-
Q27136693
AKOS040734461
723302-27-0

Research Excerpts

Bioavailability

ExcerptReferenceRelevance
"The ATP-binding cassette transporter P-glycoprotein (P-gp) is known to limit both brain penetration and oral bioavailability of many chemotherapy drugs."( A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Ambudkar, SV; Brimacombe, KR; Chen, L; Gottesman, MM; Guha, R; Hall, MD; Klumpp-Thomas, C; Lee, OW; Lee, TD; Lusvarghi, S; Robey, RW; Shen, M; Tebase, BG, 2019)		0.51
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (1)

RoleDescription
metaboliteAny intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (1)

ClassDescription
tertiary alcoholA tertiary alcohol is a compound in which a hydroxy group, -OH, is attached to a saturated carbon atom which has three other carbon atoms attached to it.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (37)

Assay IDTitleYearJournalArticle
AID1296008Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening2020SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening.
AID1346986P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen2019Molecular pharmacology, 11, Volume: 96, Issue:5
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID1347160Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors2020Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1347159Primary screen GU Rhodamine qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay2020Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1346987P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen2019Molecular pharmacology, 11, Volume: 96, Issue:5
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID612489Inhibition of wild type MET assessed as 33Pi incorporation after 60 mins by scintillation counting2011Bioorganic & medicinal chemistry, Aug-01, Volume: 19, Issue:15
Arthrinins A-D: novel diterpenoids and further constituents from the sponge derived fungus Arthrinium sp.
AID354475Antibacterial activity against Escherichia coli at 50 ug/disk by agar diffusion assay2004Journal of natural products, Jun, Volume: 67, Issue:6
New secondary metabolites from the marine endophytic fungus Apiospora montagnei.
AID612496Inhibition of recombinant VEGF-R2 assessed as 33Pi incorporation after 60 mins by scintillation counting2011Bioorganic & medicinal chemistry, Aug-01, Volume: 19, Issue:15
Arthrinins A-D: novel diterpenoids and further constituents from the sponge derived fungus Arthrinium sp.
AID354470Cytotoxicity against human HepG2 cells at 10 ug/ml2004Journal of natural products, Jun, Volume: 67, Issue:6
New secondary metabolites from the marine endophytic fungus Apiospora montagnei.
AID612494Inhibition of recombinant PRK1 assessed as 33Pi incorporation after 60 mins by scintillation counting2011Bioorganic & medicinal chemistry, Aug-01, Volume: 19, Issue:15
Arthrinins A-D: novel diterpenoids and further constituents from the sponge derived fungus Arthrinium sp.
AID612477Antiproliferative activity against human K562 cells after 24 hrs by MTT assay2011Bioorganic & medicinal chemistry, Aug-01, Volume: 19, Issue:15
Arthrinins A-D: novel diterpenoids and further constituents from the sponge derived fungus Arthrinium sp.
AID354476Antifungal activity against Microbotryum violaceum at 50 ug/disk by agar diffusion assay2004Journal of natural products, Jun, Volume: 67, Issue:6
New secondary metabolites from the marine endophytic fungus Apiospora montagnei.
AID612483Inhibition of recombinant ARK5 assessed as 33Pi incorporation after 60 mins by scintillation counting2011Bioorganic & medicinal chemistry, Aug-01, Volume: 19, Issue:15
Arthrinins A-D: novel diterpenoids and further constituents from the sponge derived fungus Arthrinium sp.
AID612485Inhibition of recombinant AXL assessed as 33Pi incorporation after 60 mins by scintillation counting2011Bioorganic & medicinal chemistry, Aug-01, Volume: 19, Issue:15
Arthrinins A-D: novel diterpenoids and further constituents from the sponge derived fungus Arthrinium sp.
AID354468Cytotoxicity against human HM02 cells at 10 ug/ml2004Journal of natural products, Jun, Volume: 67, Issue:6
New secondary metabolites from the marine endophytic fungus Apiospora montagnei.
AID612481Inhibition of recombinant AKT1 assessed as 33Pi incorporation after 60 mins by scintillation counting2011Bioorganic & medicinal chemistry, Aug-01, Volume: 19, Issue:15
Arthrinins A-D: novel diterpenoids and further constituents from the sponge derived fungus Arthrinium sp.
AID612492Inhibition of recombinant PIM1 assessed as 33Pi incorporation after 60 mins by scintillation counting2011Bioorganic & medicinal chemistry, Aug-01, Volume: 19, Issue:15
Arthrinins A-D: novel diterpenoids and further constituents from the sponge derived fungus Arthrinium sp.
AID611589Antiangiogenesis activity in HUVEC assessed as inhibition of VEGF-induced cell proliferation after 72 hrs by MTT assay2011Journal of natural products, Jul-22, Volume: 74, Issue:7
Chemical constituents of a marine fungus, Arthrinium sacchari.
AID612482Inhibition of recombinant ALK assessed as 33Pi incorporation after 60 mins by scintillation counting2011Bioorganic & medicinal chemistry, Aug-01, Volume: 19, Issue:15
Arthrinins A-D: novel diterpenoids and further constituents from the sponge derived fungus Arthrinium sp.
AID612484Inhibition of recombinant Aurora-b assessed as 33Pi incorporation after 60 mins by scintillation counting2011Bioorganic & medicinal chemistry, Aug-01, Volume: 19, Issue:15
Arthrinins A-D: novel diterpenoids and further constituents from the sponge derived fungus Arthrinium sp.
AID612488Inhibition of wild type MEK1 assessed as 33Pi incorporation after 60 mins by scintillation counting2011Bioorganic & medicinal chemistry, Aug-01, Volume: 19, Issue:15
Arthrinins A-D: novel diterpenoids and further constituents from the sponge derived fungus Arthrinium sp.
AID354474Antibacterial activity against Bacillus megaterium at 50 ug/disk by agar diffusion assay2004Journal of natural products, Jun, Volume: 67, Issue:6
New secondary metabolites from the marine endophytic fungus Apiospora montagnei.
AID612497Inhibition of VEGF-A induced HUVEC cell sprouting after 24 hrs by angiogenesis assay2011Bioorganic & medicinal chemistry, Aug-01, Volume: 19, Issue:15
Arthrinins A-D: novel diterpenoids and further constituents from the sponge derived fungus Arthrinium sp.
AID611590Antiangiogenesis activity in HUAEC assessed as inhibition of VEGF-induced cell proliferation after 72 hrs by MTT assay2011Journal of natural products, Jul-22, Volume: 74, Issue:7
Chemical constituents of a marine fungus, Arthrinium sacchari.
AID354478Antifungal activity against Mycotypha microspora at 50 ug/disk by agar diffusion assay2004Journal of natural products, Jun, Volume: 67, Issue:6
New secondary metabolites from the marine endophytic fungus Apiospora montagnei.
AID354472Cytotoxicity against human MCF7 cells at 10 ug/ml2004Journal of natural products, Jun, Volume: 67, Issue:6
New secondary metabolites from the marine endophytic fungus Apiospora montagnei.
AID612479Antiproliferative activity against human A2780 cells after 24 hrs by MTT assay2011Bioorganic & medicinal chemistry, Aug-01, Volume: 19, Issue:15
Arthrinins A-D: novel diterpenoids and further constituents from the sponge derived fungus Arthrinium sp.
AID612495Inhibition of recombinant SRC assessed as 33Pi incorporation after 60 mins by scintillation counting2011Bioorganic & medicinal chemistry, Aug-01, Volume: 19, Issue:15
Arthrinins A-D: novel diterpenoids and further constituents from the sponge derived fungus Arthrinium sp.
AID612490Inhibition of recombinant NEK2 assessed as 33Pi incorporation after 60 mins by scintillation counting2011Bioorganic & medicinal chemistry, Aug-01, Volume: 19, Issue:15
Arthrinins A-D: novel diterpenoids and further constituents from the sponge derived fungus Arthrinium sp.
AID612486Inhibition of recombinant FAK assessed as 33Pi incorporation after 60 mins by scintillation counting2011Bioorganic & medicinal chemistry, Aug-01, Volume: 19, Issue:15
Arthrinins A-D: novel diterpenoids and further constituents from the sponge derived fungus Arthrinium sp.
AID612487Inhibition of recombinant IGF1-R assessed as 33Pi incorporation after 60 mins by scintillation counting2011Bioorganic & medicinal chemistry, Aug-01, Volume: 19, Issue:15
Arthrinins A-D: novel diterpenoids and further constituents from the sponge derived fungus Arthrinium sp.
AID612491Inhibition of recombinant NEK6 assessed as 33Pi incorporation after 60 mins by scintillation counting2011Bioorganic & medicinal chemistry, Aug-01, Volume: 19, Issue:15
Arthrinins A-D: novel diterpenoids and further constituents from the sponge derived fungus Arthrinium sp.
AID354477Antifungal activity against Eurotium repens at 50 ug/disk by agar diffusion assay2004Journal of natural products, Jun, Volume: 67, Issue:6
New secondary metabolites from the marine endophytic fungus Apiospora montagnei.
AID612455Antiproliferative activity against mouse L5178Y cells after 24 hrs by MTT assay2011Bioorganic & medicinal chemistry, Aug-01, Volume: 19, Issue:15
Arthrinins A-D: novel diterpenoids and further constituents from the sponge derived fungus Arthrinium sp.
AID612493Inhibition of recombinant PLK1 assessed as 33Pi incorporation after 60 mins by scintillation counting2011Bioorganic & medicinal chemistry, Aug-01, Volume: 19, Issue:15
Arthrinins A-D: novel diterpenoids and further constituents from the sponge derived fungus Arthrinium sp.
AID354479Antialgal activity against 'Chlorella' fusca at 50 ug/disk by agar diffusion assay2004Journal of natural products, Jun, Volume: 67, Issue:6
New secondary metabolites from the marine endophytic fungus Apiospora montagnei.
AID612480Antiproliferative activity against human cisplatin resistant A2780 cells after 24 hrs by MTT assay2011Bioorganic & medicinal chemistry, Aug-01, Volume: 19, Issue:15
Arthrinins A-D: novel diterpenoids and further constituents from the sponge derived fungus Arthrinium sp.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (16.67)29.6817
2010's3 (50.00)24.3611
2020's2 (33.33)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 13.26

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index13.26 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index5.21 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (13.26)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
norlichexanthone
norlichexanthone: isolated from fungus P16; structure in first source. norlichexanthone : A member of the class of xanthones that is 9H-xanthen-9-one substituted by hydroxy groups at positions 1, 3 and 6 and a methyl group at position 8. It has been isolated from Wardomyces anomalus.		2.0610polyphenol;
xanthones		antimalarial;
fungal metabolite
su 11248
[no description available]		2.0610monocarboxylic acid amide;
pyrroles		angiogenesis inhibitor;
antineoplastic agent;
EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor;
immunomodulator;
neuroprotective agent;
vascular endothelial growth factor receptor antagonist
cytochalasin e
cytochalasin E: structure		2.0610cytochalasan alkaloidmetabolite
2-methylene-3-hexylbutanedioic acid
[no description available]		2.0210medium-chain fatty acid
kahalalide f
kahalalide F: a cyclodepsipeptide toxin; isolated from a mollusk, Elysia rubefescens; exhibits antitumoral activity against cell lines of colon cancer and prostatic cancer; structure given in first source		2.0610
ConditionIndicatedRelationship StrengthStudiesTrials
Benign Neoplasms
[description not available]		02.0610
Angiogenesis, Pathologic
[description not available]		02.0610
Neoplasms
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.		02.0610
Congenital Zika Syndrome
[description not available]		02.2510
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.		02.2510
Zika Virus Infection
A viral disease transmitted by the bite of AEDES mosquitoes infected with ZIKA VIRUS. Its mild DENGUE-like symptoms include fever, rash, headaches and ARTHRALGIA. The viral infection during pregnancy, in rare cases, is associated with congenital brain and ocular abnormalities, called Congenital Zika Syndrome, including MICROCEPHALY and may also lead to GUILLAIN-BARRE SYNDROME.		02.2510