manganese chloride profile

CMC-001: oral manganese-containing contrast agent for liver and bile imaging [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	26003
MeSH ID	M0084556

Synonym
mangoral
cmc-001
cmc001
manganese chloride tetrahydrate [who-dd]
manganese chloride [inci]
manganese (as chloride) [vandf]
manganese chloride [orange book]
manganese chloride tetrahydrate [orange book]
manganese chloride [vandf]
manganese chloride [fcc]
manganese chloride tetrahydrate [mi]
manganum muriaticum [hpus]
tetrahydrate manganese(ii) chloride
CNFDGXZLMLFIJV-UHFFFAOYSA-L
AKOS030227978
manganese(ii) chloride tetrahydrate acs grade

Research Excerpts

Toxicity

Excerpt	Reference	Relevance
" Adverse drug reactions/adverse events (ADRs/AEs) and clinico-laboratory tests were monitored."	( Manganese chloride tetrahydrate (CMC-001) enhanced liver MRI: evaluation of efficacy and safety in healthy volunteers. Albiin, N; Bergquist, A; Brismar, TB; Kartalis, N; Sadigh, B, 2012)	0.38

Bioavailability

Excerpt	Reference	Relevance
" Under physiological circumstances manganese is poorly absorbed from the intestine after oral intake, but by the use of specific absorption promoters, L-alanine and vitamin D(3), it is possible to obtain a sufficiently high concentration in the liver in order to achieve a significant signal enhancing effect."	( A new manganese-based oral contrast agent (CMC-001) for liver MRI: pharmacological and pharmaceutical aspects. Albiin, N; Brismar, TB; Jørgensen, JT; Rief, M; Wagner, M, 2012)	0.38

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Role	Description
nutraceutical	A product in capsule, tablet or liquid form that provide essential nutrients, such as a vitamin, an essential mineral, a protein, an herb, or similar nutritional substance.
MRI contrast agent	null
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Class	Description
hydrate	An addition compound that contains water in weak chemical combination with another compound.
inorganic chloride
manganese coordination entity
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	4 (57.14)	29.6817
2010's	3 (42.86)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	4 (57.14%)	5.53%
Reviews	1 (14.29%)	6.00%
Case Studies	1 (14.29%)	4.05%
Observational	0 (0.00%)	0.25%
Other	1 (14.29%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
chlorine chloride : A halide anion formed when chlorine picks up an electron to form an an anion.	3.41	1	1	halide anion; monoatomic chlorine	cofactor; Escherichia coli metabolite; human metabolite
meglumine Meglumine: 1-Deoxy-1-(methylamino)-D-glucitol. A derivative of sorbitol in which the hydroxyl group in position 1 is replaced by a methylamino group. Often used in conjunction with iodinated organic compounds as contrast medium.. N-methylglucamine : A hexosamine that is D-glucitol in which the hydroxy group at position 1 is substituted by the nitrogen of a methylamino group. A crystalline base, it is used in preparing salts of certain acids for use as diagnostic radiopaque media, while its antimonate is used as an antiprotozoal in the treatment of leishmaniasis.	3.46	1	1	hexosamine; secondary amino compound
sulfur hexafluoride Sulfur Hexafluoride: Sulfur hexafluoride. An inert gas used mainly as a test gas in respiratory physiology. Other uses include its injection in vitreoretinal surgery to restore the vitreous chamber and as a tracer in monitoring the dispersion and deposition of air pollutants.. sulfur hexafluoride : A sulfur coordination entity consisting of six fluorine atoms attached to a central sulfur atom. It is the most potent greenhouse gas currently known, with a global warming potential of 23,900 times that of CO2 over a 100 year period (SF6 has an estimated lifetime in the atmosphere of between 800 and 3,000 years).	3.46	1	1	sulfur coordination entity	greenhouse gas; NMR chemical shift reference compound; ultrasound contrast agent
manganese Manganese: A trace element with atomic symbol Mn, atomic number 25, and atomic weight 54.94. It is concentrated in cell mitochondria, mostly in the pituitary gland, liver, pancreas, kidney, and bone, influences the synthesis of mucopolysaccharides, stimulates hepatic synthesis of cholesterol and fatty acids, and is a cofactor in many enzymes, including arginase and alkaline phosphatase in the liver. (From AMA Drug Evaluations Annual 1992, p2035). manganese(4+) : A manganese cation that is monoatomic and has a formal charge of +4.	12.09	7	4	elemental manganese; manganese group element atom	Escherichia coli metabolite; micronutrient

Condition	Relationship Strength	Studies	Trials
Cancer of Liver [description not available]	4.4	2	2
Colorectal Cancer [description not available]	3.46	1	1
Liver Neoplasms Tumors or cancer of the LIVER.	4.4	2	2
Sensitivity and Specificity Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)	4.78	2	1
Colorectal Neoplasms Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.	3.46	1	1
Liver Dysfunction [description not available]	3.37	2	0
Liver Diseases Pathological processes of the LIVER.	3.37	2	0
Bladder Cancer [description not available]	3.41	1	1
Cancer of Colon [description not available]	3.41	1	1
Cancer of Kidney [description not available]	3.41	1	1
Metastase [description not available]	3.41	1	1
Urinary Bladder Neoplasms Tumors or cancer of the URINARY BLADDER.	3.41	1	1
Colonic Neoplasms Tumors or cancer of the COLON.	3.41	1	1
Kidney Neoplasms Tumors or cancers of the KIDNEY.	3.41	1	1
Neoplasm Metastasis The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.	3.41	1	1
Bile Duct Obstruction, Intrahepatic [description not available]	2.03	1	0
Amyloidosis A group of sporadic, familial and/or inherited, degenerative, and infectious disease processes, linked by the common theme of abnormal protein folding and deposition of AMYLOID. As the amyloid deposits enlarge they displace normal tissue structures, causing disruption of function. Various signs and symptoms depend on the location and size of the deposits.	2.03	1	0
Atrophy Decrease in the size of a cell, tissue, organ, or multiple organs, associated with a variety of pathological conditions such as abnormal cellular changes, ischemia, malnutrition, or hormonal changes.	2.03	1	0
Cholestasis, Intrahepatic Impairment of bile flow due to injury to the HEPATOCYTES; BILE CANALICULI; or the intrahepatic bile ducts (BILE DUCTS, INTRAHEPATIC).	2.03	1	0

manganese chloride

Description

Cross-References

Synonyms (16)

Research Excerpts

Toxicity

Bioavailability

Roles (2)

Drug Classes (3)

Research

Studies (7)

Study Types

manganese chloride

Description

Cross-References

Synonyms (16)

Research Excerpts

Toxicity

Bioavailability

Roles (2)

Drug Classes (3)

Research

Studies (7)

Study Types

Related Drugs (4)

Related Conditions (19)