Compounds > lenthionine
Page last updated: 2024-11-06

lenthionine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Lenthionine is a sulfur-containing amino acid derivative found in the fruiting bodies of the edible mushroom *Lentinula edodes* (shiitake). It is known for its potential health benefits, including antioxidant, anti-inflammatory, and immune-modulatory properties. Lenthionine is thought to act by stimulating the production of cytokines, which are signaling molecules involved in the immune response. Studies have shown that lenthionine may have potential benefits for conditions such as cancer, cardiovascular disease, and diabetes. However, further research is needed to confirm these effects and establish safe and effective dosages.'

lenthionine: isolated from the Shiitake mushroom Lenthinus edodes [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID67521
CHEMBL ID4288485
CHEBI ID6408
SCHEMBL ID2675229
MeSH IDM0474534

Synonyms (29)

Synonym
CHEBI:6408
nsc-291119
1,3,5,6-pentathiepane
lenthionin
nsc291119
C08382
292-46-6
1,2,3,5,6-pentathiepane
lenthionine
AKOS006276442
[1,2,3,5,6]pentathiepane
nsc 291119
unii-71g9u1cird
71g9u1cird ,
A819840
1,2,3,5,6-pentathiacycloheptane
FT-0627791
lenthionine [mi]
4-aminobenzylphosphonicacid
1,2,3,5,6-pentasulfur-cycloheptane
SCHEMBL2675229
DZKOKXZNCDGVRY-UHFFFAOYSA-N
mfcd03840531
DTXSID20183460
BCP19093
Q3181449
AS-33132
CHEMBL4288485
CS-0186285
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
pentathiepane
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (9)

Assay IDTitleYearJournalArticle
AID1419813Antimicrobial activity against Glomerella cingulata2017Journal of natural products, 11-22, Volume: 80, Issue:11
Natural Products with Heteroatom-Rich Ring Systems.
AID1419772Antibacterial activity against Bacillus subtilis2017Journal of natural products, 11-22, Volume: 80, Issue:11
Natural Products with Heteroatom-Rich Ring Systems.
AID1419811Antifungal activity against Candida albicans2017Journal of natural products, 11-22, Volume: 80, Issue:11
Natural Products with Heteroatom-Rich Ring Systems.
AID1419816Antimicrobial activity against Cryptococcus neoformans2017Journal of natural products, 11-22, Volume: 80, Issue:11
Natural Products with Heteroatom-Rich Ring Systems.
AID1419788Antifungal activity against Trichophyton rubrum2017Journal of natural products, 11-22, Volume: 80, Issue:11
Natural Products with Heteroatom-Rich Ring Systems.
AID1419815Antimicrobial activity against Saccharomyces cerevisiae2017Journal of natural products, 11-22, Volume: 80, Issue:11
Natural Products with Heteroatom-Rich Ring Systems.
AID1419774Antibacterial activity against Proteus vulgaris2017Journal of natural products, 11-22, Volume: 80, Issue:11
Natural Products with Heteroatom-Rich Ring Systems.
AID1419812Antimicrobial activity against Pyricularia orizae2017Journal of natural products, 11-22, Volume: 80, Issue:11
Natural Products with Heteroatom-Rich Ring Systems.
AID1419814Antimicrobial activity against Trichophyton mentagrophytes2017Journal of natural products, 11-22, Volume: 80, Issue:11
Natural Products with Heteroatom-Rich Ring Systems.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (33.33)29.6817
2010's2 (33.33)24.3611
2020's2 (33.33)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 27.39

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index27.39 (24.57)
Research Supply Index2.08 (2.92)
Research Growth Index4.80 (4.65)
Search Engine Demand Index29.35 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (27.39)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials1 (16.67%)5.53%
Reviews1 (16.67%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other4 (66.67%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
azacitidine
Azacitidine: A pyrimidine analogue that inhibits DNA methyltransferase, impairing DNA methylation. It is also an antimetabolite of cytidine, incorporated primarily into RNA. Azacytidine has been used as an antineoplastic agent.. 5-azacytidine : An N-glycosyl-1,3,5-triazine that is 4-amino-1,3,5-triazin-2(1H)-one substituted by a beta-D-ribofuranosyl residue via an N-glycosidic linkage. An antineoplastic agent, it is used in the treatment of myeloid leukaemia.		3.2510N-glycosyl-1,3,5-triazine;
nucleoside analogue		antineoplastic agent
eudistomin e
eudistomin E: structure known; isolated from the marine tunicate Eudistoma album		3.2510
betadex
beta-Cyclodextrins: Cyclic GLUCANS consisting of seven (7) glucopyranose units linked by 1,4-glycosidic bonds.		2.0210cyclodextrin
alpha-cyclodextrin
alpha-cyclodextrin : A cycloamylose composed of six alpha-(1->4) linked D-glucopyranose units.		2.0210cyclodextrin
lithium
Lithium: An element in the alkali metals family. It has the atomic symbol Li, atomic number 3, and atomic weight [6.938; 6.997]. Salts of lithium are used in treating BIPOLAR DISORDER.		7.4110alkali metal atom
gamma-cyclodextrin
gamma-cyclodextrin : A cycloamylose composed of eight alpha-(1->4) linked D-glucopyranose units.		2.0210cyclodextrin
cysteine
Cysteine: A thiol-containing non-essential amino acid that is oxidized to form CYSTINE.. L-cysteinium : The L-enantiomer of cysteinium.. cysteine : A sulfur-containing amino acid that is propanoic acid with an amino group at position 2 and a sulfanyl group at position 3.		2.3110cysteiniumfundamental metabolite
essramycin
essramycin: from the culture broth of the marine Streptomyces; structure in first source		3.2510triazolopyrimidinesmetabolite
phidianidine a
phidianidine A: antineoplastic from the marine opisthobranch mollusk Phidiana militaris; structure in first source		3.2510
phidianidine b
phidianidine B: antineoplastic from the marine opisthobranch mollusk Phidiana militaris; structure in first source		3.2510
maltodextrin
maltodextrin : A dextrin in which the D-glucose units are linked by alpha-(1->4) glycosidic bonds.		2.0210
ConditionIndicatedRelationship StrengthStudiesTrials
Abdominal Aortic Aneurysm
[description not available]		03.4111
Complication, Postoperative
[description not available]		03.4111
Postoperative Complications
Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.		03.4111
Aortic Aneurysm, Abdominal
An abnormal balloon- or sac-like dilatation in the wall of the ABDOMINAL AORTA which gives rise to the visceral, the parietal, and the terminal (iliac) branches below the aortic hiatus at the diaphragm.		03.4111