phidianidine a

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

phidianidine A: antineoplastic from the marine opisthobranch mollusk Phidiana militaris; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	59053149
CHEMBL ID	4280846
SCHEMBL ID	15275630
MeSH ID	M0558905

Synonyms (8)

Synonym
SCHEMBL15275630
phidianidine a
1301638-41-4
1-(5-((5-((6-bromo-1h-indol-3-yl)methyl)-1,2,4-oxadiazol-3-yl)amino)pentyl)guanidine
CHEMBL4280846
nsc764069
nsc-764069
STARBLD0009368

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (9)

Assay ID	Title	Year	Journal	Article
AID1419746	Inhibition of norepinephrine transporter (unknown origin) at 10 uM	2017	Journal of natural products, 11-22, Volume: 80, Issue:11	Natural Products with Heteroatom-Rich Ring Systems.
AID1419750	Antagonist activity at CXCR4 in rat GH4C1 cells assessed as inhibition of CXCL12-induced DNA synthesis at 10 uM after 72 hrs by BrdU incorporation assay	2017	Journal of natural products, 11-22, Volume: 80, Issue:11	Natural Products with Heteroatom-Rich Ring Systems.
AID1419742	Cytotoxicity against mouse 3T3L1 cells assessed as decrease in cell viability	2017	Journal of natural products, 11-22, Volume: 80, Issue:11	Natural Products with Heteroatom-Rich Ring Systems.
AID1419745	Inhibition of dopamine transporter (unknown origin) at 10 uM	2017	Journal of natural products, 11-22, Volume: 80, Issue:11	Natural Products with Heteroatom-Rich Ring Systems.
AID1419748	Inhibition of mu opioid receptor (unknown origin) at 10 uM	2017	Journal of natural products, 11-22, Volume: 80, Issue:11	Natural Products with Heteroatom-Rich Ring Systems.
AID1419747	Inhibition of serotonin transporter (unknown origin) at 10 uM	2017	Journal of natural products, 11-22, Volume: 80, Issue:11	Natural Products with Heteroatom-Rich Ring Systems.
AID1419744	Cytotoxicity against human HeLa cells assessed as decrease in cell viability	2017	Journal of natural products, 11-22, Volume: 80, Issue:11	Natural Products with Heteroatom-Rich Ring Systems.
AID1419749	Antagonist activity at CXCR4 in rat GH4C1 cells assessed as inhibition of CXCL12-induced cell migration at 0.1 uM after 72 hrs by BrdU incorporation assay	2017	Journal of natural products, 11-22, Volume: 80, Issue:11	Natural Products with Heteroatom-Rich Ring Systems.
AID1419743	Cytotoxicity against rat C6 cells assessed as decrease in cell viability	2017	Journal of natural products, 11-22, Volume: 80, Issue:11	Natural Products with Heteroatom-Rich Ring Systems.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	7 (87.50)	24.3611
2020's	1 (12.50)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.31

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	12.31 (24.57)
Research Supply Index	2.20 (2.92)
Research Growth Index	4.51 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (12.31)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	2 (25.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	6 (75.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
azacitidine Azacitidine: A pyrimidine analogue that inhibits DNA methyltransferase, impairing DNA methylation. It is also an antimetabolite of cytidine, incorporated primarily into RNA. Azacytidine has been used as an antineoplastic agent.. 5-azacytidine : An N-glycosyl-1,3,5-triazine that is 4-amino-1,3,5-triazin-2(1H)-one substituted by a beta-D-ribofuranosyl residue via an N-glycosidic linkage. An antineoplastic agent, it is used in the treatment of myeloid leukaemia.	3.25	1	N-glycosyl-1,3,5-triazine; nucleoside analogue	antineoplastic agent
lenthionine lenthionine: isolated from the Shiitake mushroom Lenthinus edodes	3.25	1	pentathiepane
eudistomin e eudistomin E: structure known; isolated from the marine tunicate Eudistoma album	3.25	1
oxadiazoles Oxadiazoles: Compounds containing five-membered heteroaromatic rings containing two carbons, two nitrogens, and one oxygen atom which exist in various regioisomeric forms.	4.58	7
essramycin essramycin: from the culture broth of the marine Streptomyces; structure in first source	3.25	1	triazolopyrimidines	metabolite
phidianidine b phidianidine B: antineoplastic from the marine opisthobranch mollusk Phidiana militaris; structure in first source	4.96	6
guanosine 5'-o-(3-thiotriphosphate) Guanosine 5'-O-(3-Thiotriphosphate): Guanosine 5'-(trihydrogen diphosphate), monoanhydride with phosphorothioic acid. A stable GTP analog which enjoys a variety of physiological actions such as stimulation of guanine nucleotide-binding proteins, phosphoinositide hydrolysis, cyclic AMP accumulation, and activation of specific proto-oncogenes.	2.07	1	nucleoside triphosphate analogue

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