Compounds > phidianidine a
Page last updated: 2024-11-13

phidianidine a

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

phidianidine A: antineoplastic from the marine opisthobranch mollusk Phidiana militaris; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID59053149
CHEMBL ID4280846
SCHEMBL ID15275630
MeSH IDM0558905

Synonyms (8)

Synonym
SCHEMBL15275630
phidianidine a
1301638-41-4
1-(5-((5-((6-bromo-1h-indol-3-yl)methyl)-1,2,4-oxadiazol-3-yl)amino)pentyl)guanidine
CHEMBL4280846
nsc764069
nsc-764069
STARBLD0009368
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (9)

Assay IDTitleYearJournalArticle
AID1419746Inhibition of norepinephrine transporter (unknown origin) at 10 uM2017Journal of natural products, 11-22, Volume: 80, Issue:11
Natural Products with Heteroatom-Rich Ring Systems.
AID1419750Antagonist activity at CXCR4 in rat GH4C1 cells assessed as inhibition of CXCL12-induced DNA synthesis at 10 uM after 72 hrs by BrdU incorporation assay2017Journal of natural products, 11-22, Volume: 80, Issue:11
Natural Products with Heteroatom-Rich Ring Systems.
AID1419742Cytotoxicity against mouse 3T3L1 cells assessed as decrease in cell viability2017Journal of natural products, 11-22, Volume: 80, Issue:11
Natural Products with Heteroatom-Rich Ring Systems.
AID1419745Inhibition of dopamine transporter (unknown origin) at 10 uM2017Journal of natural products, 11-22, Volume: 80, Issue:11
Natural Products with Heteroatom-Rich Ring Systems.
AID1419748Inhibition of mu opioid receptor (unknown origin) at 10 uM2017Journal of natural products, 11-22, Volume: 80, Issue:11
Natural Products with Heteroatom-Rich Ring Systems.
AID1419747Inhibition of serotonin transporter (unknown origin) at 10 uM2017Journal of natural products, 11-22, Volume: 80, Issue:11
Natural Products with Heteroatom-Rich Ring Systems.
AID1419744Cytotoxicity against human HeLa cells assessed as decrease in cell viability2017Journal of natural products, 11-22, Volume: 80, Issue:11
Natural Products with Heteroatom-Rich Ring Systems.
AID1419749Antagonist activity at CXCR4 in rat GH4C1 cells assessed as inhibition of CXCL12-induced cell migration at 0.1 uM after 72 hrs by BrdU incorporation assay2017Journal of natural products, 11-22, Volume: 80, Issue:11
Natural Products with Heteroatom-Rich Ring Systems.
AID1419743Cytotoxicity against rat C6 cells assessed as decrease in cell viability2017Journal of natural products, 11-22, Volume: 80, Issue:11
Natural Products with Heteroatom-Rich Ring Systems.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's7 (87.50)24.3611
2020's1 (12.50)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.31

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.31 (24.57)
Research Supply Index2.20 (2.92)
Research Growth Index4.51 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.31)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews2 (25.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (75.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
azacitidine
Azacitidine: A pyrimidine analogue that inhibits DNA methyltransferase, impairing DNA methylation. It is also an antimetabolite of cytidine, incorporated primarily into RNA. Azacytidine has been used as an antineoplastic agent.. 5-azacytidine : An N-glycosyl-1,3,5-triazine that is 4-amino-1,3,5-triazin-2(1H)-one substituted by a beta-D-ribofuranosyl residue via an N-glycosidic linkage. An antineoplastic agent, it is used in the treatment of myeloid leukaemia.		3.2510N-glycosyl-1,3,5-triazine;
nucleoside analogue		antineoplastic agent
lenthionine
lenthionine: isolated from the Shiitake mushroom Lenthinus edodes		3.2510pentathiepane
eudistomin e
eudistomin E: structure known; isolated from the marine tunicate Eudistoma album		3.2510
oxadiazoles
Oxadiazoles: Compounds containing five-membered heteroaromatic rings containing two carbons, two nitrogens, and one oxygen atom which exist in various regioisomeric forms.		4.5870
essramycin
essramycin: from the culture broth of the marine Streptomyces; structure in first source		3.2510triazolopyrimidinesmetabolite
phidianidine b
phidianidine B: antineoplastic from the marine opisthobranch mollusk Phidiana militaris; structure in first source		4.9660
guanosine 5'-o-(3-thiotriphosphate)
Guanosine 5'-O-(3-Thiotriphosphate): Guanosine 5'-(trihydrogen diphosphate), monoanhydride with phosphorothioic acid. A stable GTP analog which enjoys a variety of physiological actions such as stimulation of guanine nucleotide-binding proteins, phosphoinositide hydrolysis, cyclic AMP accumulation, and activation of specific proto-oncogenes.		2.0710nucleoside triphosphate analogue
ConditionIndicatedRelationship StrengthStudiesTrials