eudistomin e

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

eudistomin E: structure known; isolated from the marine tunicate Eudistoma album [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	128900
CHEMBL ID	510254
MeSH ID	M0205067

Synonyms (9)

Synonym
eudistomin e
nsc722497
nsc-722497
88704-51-2
CHEMBL510254
(1,6,2)oxathiazepino(2',3':1,2)pyrido(3,4-b)indol-10-ol, 1-amino-9-bromo-1,2,7,8,13,13b-hexahydro-, (1s-trans)-
DTXSID401008308
1-amino-9-bromo-1,2,7,8,13,13b-hexahydro-4h-[1,6,2]oxathiazepino[2',3':1,2]pyrido[3,4-b]indol-10-ol
(2s,3s)-3-amino-13-bromo-7-oxa-5-thia-8,18-diazatetracyclo[9.7.0.02,8.012,17]octadeca-1(11),12(17),13,15-tetraen-14-ol

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (4)

Assay ID	Title	Year	Journal	Article
AID334764	Cytotoxicity against human KB cells at 0.005 to 10 ug/ml	1992	Journal of natural products, Apr, Volume: 55, Issue:4	Brominated beta-carbolines from the marine tunicate Eudistoma album.
AID334768	Cytotoxicity against human KB cells	1992	Journal of natural products, Apr, Volume: 55, Issue:4	Brominated beta-carbolines from the marine tunicate Eudistoma album.
AID1419808	Antibacterial activity against Micrococcus luteus assessed as inhibition zone at 20 ug	2017	Journal of natural products, 11-22, Volume: 80, Issue:11	Natural Products with Heteroatom-Rich Ring Systems.
AID1419809	Cytotoxicity against mouse L1210 cells assessed as decrease in cell viability at 5 ug	2017	Journal of natural products, 11-22, Volume: 80, Issue:11	Natural Products with Heteroatom-Rich Ring Systems.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	1 (20.00)	18.2507
2000's	3 (60.00)	29.6817
2010's	1 (20.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	2 (40.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	3 (60.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
azacitidine Azacitidine: A pyrimidine analogue that inhibits DNA methyltransferase, impairing DNA methylation. It is also an antimetabolite of cytidine, incorporated primarily into RNA. Azacytidine has been used as an antineoplastic agent.. 5-azacytidine : An N-glycosyl-1,3,5-triazine that is 4-amino-1,3,5-triazin-2(1H)-one substituted by a beta-D-ribofuranosyl residue via an N-glycosidic linkage. An antineoplastic agent, it is used in the treatment of myeloid leukaemia.	3.25	1	N-glycosyl-1,3,5-triazine; nucleoside analogue	antineoplastic agent
lenthionine lenthionine: isolated from the Shiitake mushroom Lenthinus edodes	3.25	1	pentathiepane
essramycin essramycin: from the culture broth of the marine Streptomyces; structure in first source	3.25	1	triazolopyrimidines	metabolite
phidianidine a phidianidine A: antineoplastic from the marine opisthobranch mollusk Phidiana militaris; structure in first source	3.25	1
phidianidine b phidianidine B: antineoplastic from the marine opisthobranch mollusk Phidiana militaris; structure in first source	3.25	1

Condition	Relationship Strength	Studies
Cancer of Colon [description not available]	2	1
Leucocythaemia [description not available]	2	1
Malignant Melanoma [description not available]	2	1
Cancer of Ovary [description not available]	2	1
Colonic Neoplasms Tumors or cancer of the COLON.	2	1
Leukemia A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)	2	1
Melanoma A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)	2	1
Ovarian Neoplasms Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.	2	1

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