L 691121: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 164390 |
| CHEMBL ID | 1204345 |
| SCHEMBL ID | 8564930 |
| MeSH ID | M0208226 |
| Synonym |
|---|
| 136075-60-0 |
| l-691-121 |
| l-691,121 |
| l 691121 |
| methanesulfonamide, n-(1'-(2-(5-benzofurazanyl)ethyl)-3,4-dihydro-4-oxospiro(2h-1-benzopyran-2,4'-piperidin-6-yl)-, monohydrochloride |
| methanesulfonamide, n-(1'-(2-(2,1,3-benzoxadiazol-5-yl)ethyl)-3,4-dihydro-4-oxospiro(2h-1-benzopyran-2,4'-piperidin)-6-yl)-, monohydrochloride |
| chembl1204345 , |
| d577xl2jji , |
| unii-d577xl2jji |
| SCHEMBL8564930 |
| NHRIUQWDVKKIAZ-UHFFFAOYSA-N |
| 3,4-dihydro-1'-[2-(benzofurazan-5-yl)ethyl]-6-methanesulfonamidospiro[(2h)-1-benzopyran-2,4'-piperidine]-4-one hydrochloride |
| methanesulfonamide, n-(1'-(2-(2,1,3-benzoxadiazol-5-yl)ethyl)-3,4-dihydro-4-oxospiro(2h-1-benzopyran-2,4'-piperidin)-6-yl)-, hydrochloride (1:1) |
| DTXSID60929248 |
| n-{1'-[2-(2,1,3-benzoxadiazol-5-yl)ethyl]-4-oxo-3,4-dihydrospiro[1-benzopyran-2,4'-piperidin]-6-yl}methanesulfonamide--hydrogen chloride (1/1) |
| n-[1'-[2-(2,1,3-benzoxadiazol-5-yl)ethyl]-4-oxospiro[3h-chromene-2,4'-piperidine]-6-yl]methanesulfonamide;hydrochloride |
| n-(1'-(2-(benzo[c][1,2,5]oxadiazol-5-yl)ethyl)-4-oxospiro[chromane-2,4'-piperidin]-6-yl)methanesulfonamide hydrochloride |
| AKOS040746015 |
| Excerpt | Relevance | Reference |
|---|---|---|
| " In order to investigate a possible mechanism for the embryolethality, GD 11 embryos were dissected from females at 4 h after dosing of 1 mg/kg and incubated for 5 h in vitro." | ( Embryotoxic effects of L-691,121, a class III antiarrhythmic agent, in rats. Ban, Y; Fujii, T; Kawana, K; Konishi, R; Manson, JM; Nakatsuka, T, 1994) | 0.29 |
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Alpha-1A adrenergic receptor | Bos taurus (cattle) | IC50 (µMol) | 1.5000 | 0.0060 | 0.4565 | 1.5000 | AID35847 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Process | via Protein(s) | Taxonomy |
|---|---|---|
| regulation of vasoconstriction | Alpha-1A adrenergic receptor | Bos taurus (cattle) |
| positive regulation of MAPK cascade | Alpha-1A adrenergic receptor | Bos taurus (cattle) |
| regulation of cardiac muscle contraction | Alpha-1A adrenergic receptor | Bos taurus (cattle) |
| [Information is prepared from geneontology information from the June-17-2024 release] | ||
| Process | via Protein(s) | Taxonomy |
|---|---|---|
| protein heterodimerization activity | Alpha-1A adrenergic receptor | Bos taurus (cattle) |
| [Information is prepared from geneontology information from the June-17-2024 release] | ||
| Process | via Protein(s) | Taxonomy |
|---|---|---|
| nucleus | Alpha-1A adrenergic receptor | Bos taurus (cattle) |
| cytoplasm | Alpha-1A adrenergic receptor | Bos taurus (cattle) |
| plasma membrane | Alpha-1A adrenergic receptor | Bos taurus (cattle) |
| caveola | Alpha-1A adrenergic receptor | Bos taurus (cattle) |
| nuclear membrane | Alpha-1A adrenergic receptor | Bos taurus (cattle) |
| [Information is prepared from geneontology information from the June-17-2024 release] | ||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID59147 | Compound was evaluated for the intravenous dose required to prolong relative refractory period (RRP) 20 ms above baseline in chloralose anesthetized dogs using a paired pacing protocol | 1992 | Journal of medicinal chemistry, Oct-16, Volume: 35, Issue:21 | 4-Oxospiro[benzopyran-2,4'-piperidines] as class III antiarrhythmic agents. Pharmacological studies on 3,4-dihydro-1'-[2-(benzofurazan-5-yl)- ethyl]-6-methanesulfonamidospiro[(2H)-1-benzopyran-2,4'-piperidin]-4-on e (L-691,121). |
| AID71928 | Compound was evaluated for the molar concentration required to prolong effective refractory period (ERP) 25% above baseline in ferret isolated right ventricular papillary muscles using a paired pacing protocol | 1992 | Journal of medicinal chemistry, Oct-16, Volume: 35, Issue:21 | 4-Oxospiro[benzopyran-2,4'-piperidines] as class III antiarrhythmic agents. Pharmacological studies on 3,4-dihydro-1'-[2-(benzofurazan-5-yl)- ethyl]-6-methanesulfonamidospiro[(2H)-1-benzopyran-2,4'-piperidin]-4-on e (L-691,121). |
| AID35847 | Compound was evaluated for binding affinity at bovine brain Alpha-1 adrenergic receptor in a filtration-based assay using [3H]prazosin as the radioligand | 1992 | Journal of medicinal chemistry, Oct-16, Volume: 35, Issue:21 | 4-Oxospiro[benzopyran-2,4'-piperidines] as class III antiarrhythmic agents. Pharmacological studies on 3,4-dihydro-1'-[2-(benzofurazan-5-yl)- ethyl]-6-methanesulfonamidospiro[(2H)-1-benzopyran-2,4'-piperidin]-4-on e (L-691,121). |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (80.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 6 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||