Compounds > karavilagenin c
Page last updated: 2024-11-13

karavilagenin c

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Description

karavilagenin C: isolated from the African medicinal plant Momordica balsamina; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

FloraRankFlora DefinitionFamilyFamily Definition
MomordicagenusA plant genus of the family CUCURBITACEAE. It is a source of momordin.[MeSH]CucurbitaceaeThe gourd plant family of the order Violales, subclass Dilleniidae, class Magnoliopsida. It is sometimes placed in its own order, Cucurbitales. 'Melon' generally refers to CUCUMIS; CITRULLUS; or MOMORDICA.[MeSH]

Cross-References

ID SourceID
PubMed CID46182790
CHEMBL ID596244
MeSH IDM0584937

Synonyms (2)

Synonym
CHEMBL596244
karavilagenin c
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (43)

Assay IDTitleYearJournalArticle
AID455732Reversal of human MDR1-mediated multidrug resistance in mouse L5178Y cells expressing MDR1 assessed as forward scatter count measured by cell size ratio at 1 uM after 10 mins by flow cytometry2009Bioorganic & medicinal chemistry, Oct-01, Volume: 17, Issue:19
New potent P-glycoprotein modulators with the cucurbitane scaffold and their synergistic interaction with doxorubicin on resistant cancer cells.
AID455729Antiproliferative activity against multidrug resistance mouse L5178Y cells expressing human MDR1 after 72 hrs by MTT assay2009Bioorganic & medicinal chemistry, Oct-01, Volume: 17, Issue:19
New potent P-glycoprotein modulators with the cucurbitane scaffold and their synergistic interaction with doxorubicin on resistant cancer cells.
AID455728Antiproliferative activity against mouse L5178Y cells after 72 hrs by MTT assay2009Bioorganic & medicinal chemistry, Oct-01, Volume: 17, Issue:19
New potent P-glycoprotein modulators with the cucurbitane scaffold and their synergistic interaction with doxorubicin on resistant cancer cells.
AID455735Reversal of human MDR1-mediated multidrug resistance in mouse L5178Y cells expressing MDR1 assessed as mean fluorescence intensity of rhodamine-123 uptake at 0.5 uM after 10 mins by flow cytometry2009Bioorganic & medicinal chemistry, Oct-01, Volume: 17, Issue:19
New potent P-glycoprotein modulators with the cucurbitane scaffold and their synergistic interaction with doxorubicin on resistant cancer cells.
AID455722Reversal of human MDR1-mediated multidrug resistance in mouse L5178Y cells expressing MDR1 assessed as mean fluorescence intensity of rhodamine-123 uptake at 20 uM after 10 mins by flow cytometry2009Bioorganic & medicinal chemistry, Oct-01, Volume: 17, Issue:19
New potent P-glycoprotein modulators with the cucurbitane scaffold and their synergistic interaction with doxorubicin on resistant cancer cells.
AID455730Potentiation of doxorubicin-induced anticancer activity against mouse L5178Y cells expressing MDR1 assessed as fractional inhibitory concentration after 72 hrs by checkerboard microplate assay2009Bioorganic & medicinal chemistry, Oct-01, Volume: 17, Issue:19
New potent P-glycoprotein modulators with the cucurbitane scaffold and their synergistic interaction with doxorubicin on resistant cancer cells.
AID1247263Antimalarial activity against Plasmodium berghei NK65 infected in BALB/c mouse assessed as inhibition of parasitemia at 50 mg/kg, sc qd for 4 days measured on 5th day after parasite inoculation by Giemsa staining based microscopy relative to control2015European journal of medicinal chemistry, Sep-18, Volume: 102In vivo evaluation of isolated triterpenes and semi-synthetic derivatives as antimalarial agents.
AID455740Octanol-water partition coefficient, log D of the compound2009Bioorganic & medicinal chemistry, Oct-01, Volume: 17, Issue:19
New potent P-glycoprotein modulators with the cucurbitane scaffold and their synergistic interaction with doxorubicin on resistant cancer cells.
AID549857Cytotoxicity against human MCF7 cells after 24 hrs by MTT assay2011Bioorganic & medicinal chemistry, Jan-01, Volume: 19, Issue:1
Karavilagenin C derivatives as antimalarials.
AID549855Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in erythrocytes after 48 hrs by SYBR Green 1-based fluorescence assay2011Bioorganic & medicinal chemistry, Jan-01, Volume: 19, Issue:1
Karavilagenin C derivatives as antimalarials.
AID455727Reversal of human MDR1-mediated multidrug resistance in mouse L5178Y cells expressing MDR1 assessed as mean fluorescence intensity of rhodamine-123 uptake after 10 mins by flow cytometry2009Bioorganic & medicinal chemistry, Oct-01, Volume: 17, Issue:19
New potent P-glycoprotein modulators with the cucurbitane scaffold and their synergistic interaction with doxorubicin on resistant cancer cells.
AID1247264Antimalarial activity against Plasmodium berghei NK65 infected in BALB/c mouse assessed as inhibition of parasitemia at 50 mg/kg, sc qd for 4 days measured on 7th day after parasite inoculation by Giemsa staining based microscopy relative to control2015European journal of medicinal chemistry, Sep-18, Volume: 102In vivo evaluation of isolated triterpenes and semi-synthetic derivatives as antimalarial agents.
AID455726Reversal of multidrug resistance in mouse L5178Y cells assessed as mean fluorescence intensity of rhodamine-123 uptake after 10 mins by flow cytometry2009Bioorganic & medicinal chemistry, Oct-01, Volume: 17, Issue:19
New potent P-glycoprotein modulators with the cucurbitane scaffold and their synergistic interaction with doxorubicin on resistant cancer cells.
AID1182533Antiplasmodial activity against GFP-expressing liver stage Plasmodium berghei sporozoites infected in human Huh7 cells preincubated for 1 hr before infection at 15 uM measured after 48 hrs post infection by firefly luciferase reporter gene assay2014Bioorganic & medicinal chemistry, Aug-01, Volume: 22, Issue:15
Dual-stage triterpenoids from an African medicinal plant targeting the malaria parasite.
AID550019Selectivity index, ratio of IC50 for human MCF7 cells to IC50 for chloroquine-resistant Plasmodium falciparum Dd22011Bioorganic & medicinal chemistry, Jan-01, Volume: 19, Issue:1
Karavilagenin C derivatives as antimalarials.
AID1182535Cytotoxicity against human HuH7 cells up to 15 uM after 48 hrs by Alamar Blue assay2014Bioorganic & medicinal chemistry, Aug-01, Volume: 22, Issue:15
Dual-stage triterpenoids from an African medicinal plant targeting the malaria parasite.
AID455715Reversal of human MDR1-mediated multidrug resistance in mouse L5178Y cells expressing MDR1 assessed as forward scatter count measured by cell size ratio at 2 uM after 10 mins by flow cytometry2009Bioorganic & medicinal chemistry, Oct-01, Volume: 17, Issue:19
New potent P-glycoprotein modulators with the cucurbitane scaffold and their synergistic interaction with doxorubicin on resistant cancer cells.
AID1247259Antimalarial activity against Plasmodium berghei NK65 infected in BALB/c mouse assessed as inhibition of parasitemia at 25 mg/kg, po qd for 4 days measured on 5th day after parasite inoculation by Giemsa staining based microscopy relative to control2015European journal of medicinal chemistry, Sep-18, Volume: 102In vivo evaluation of isolated triterpenes and semi-synthetic derivatives as antimalarial agents.
AID1247267Antimalarial activity against Plasmodium berghei NK65 infected in BALB/c mouse assessed as mean survival time at 25 mg/kg, po qd for 4 days (Rvb = 22 +/- 3 days)2015European journal of medicinal chemistry, Sep-18, Volume: 102In vivo evaluation of isolated triterpenes and semi-synthetic derivatives as antimalarial agents.
AID1182532Antiplasmodial activity against GFP-expressing liver stage Plasmodium berghei sporozoites infected in human Huh7 cells preincubated for 1 hr before infection at 5 uM measured after 48 hrs post infection by firefly luciferase reporter gene assay2014Bioorganic & medicinal chemistry, Aug-01, Volume: 22, Issue:15
Dual-stage triterpenoids from an African medicinal plant targeting the malaria parasite.
AID455719Reversal of human MDR1-mediated multidrug resistance in mouse L5178Y cells expressing MDR1 assessed as side scatter count measured by cell size ratio at 20 uM after 10 mins by flow cytometry2009Bioorganic & medicinal chemistry, Oct-01, Volume: 17, Issue:19
New potent P-glycoprotein modulators with the cucurbitane scaffold and their synergistic interaction with doxorubicin on resistant cancer cells.
AID455724Reversal of human MDR1-mediated multidrug resistance in mouse L5178Y cells expressing MDR1 assessed as fluorescence activity ratio at 2 uM after 10 mins by rhodamine-123 exclusion test2009Bioorganic & medicinal chemistry, Oct-01, Volume: 17, Issue:19
New potent P-glycoprotein modulators with the cucurbitane scaffold and their synergistic interaction with doxorubicin on resistant cancer cells.
AID1247268Antimalarial activity against Plasmodium berghei NK65 infected in BALB/c mouse assessed as mean survival time at 50 mg/kg, sc qd for 4 days (Rvb = 23 +/- 4 days)2015European journal of medicinal chemistry, Sep-18, Volume: 102In vivo evaluation of isolated triterpenes and semi-synthetic derivatives as antimalarial agents.
AID1182531Antiplasmodial activity against GFP-expressing liver stage Plasmodium berghei sporozoites infected in human Huh7 cells preincubated for 1 hr before infection at 1 uM measured after 48 hrs post infection by firefly luciferase reporter gene assay2014Bioorganic & medicinal chemistry, Aug-01, Volume: 22, Issue:15
Dual-stage triterpenoids from an African medicinal plant targeting the malaria parasite.
AID455716Reversal of human MDR1-mediated multidrug resistance in mouse L5178Y cells expressing MDR1 assessed as forward scatter count measured by cell size ratio at 20 uM after 10 mins by flow cytometry2009Bioorganic & medicinal chemistry, Oct-01, Volume: 17, Issue:19
New potent P-glycoprotein modulators with the cucurbitane scaffold and their synergistic interaction with doxorubicin on resistant cancer cells.
AID549858Selectivity index, ratio of IC50 for human MCF7 cells to IC50 for chloroquine-sensitive Plasmodium falciparum 3D72011Bioorganic & medicinal chemistry, Jan-01, Volume: 19, Issue:1
Karavilagenin C derivatives as antimalarials.
AID455721Reversal of human MDR1-mediated multidrug resistance in mouse L5178Y cells expressing MDR1 assessed as mean fluorescence intensity of rhodamine-123 uptake at 2 uM after 10 mins by flow cytometry2009Bioorganic & medicinal chemistry, Oct-01, Volume: 17, Issue:19
New potent P-glycoprotein modulators with the cucurbitane scaffold and their synergistic interaction with doxorubicin on resistant cancer cells.
AID1247266Antimalarial activity against Plasmodium berghei NK65 infected in BALB/c mouse assessed as mean survival time at 50 mg/kg, po qd for 4 days (Rvb = 22 +/- 3 days)2015European journal of medicinal chemistry, Sep-18, Volume: 102In vivo evaluation of isolated triterpenes and semi-synthetic derivatives as antimalarial agents.
AID455718Reversal of human MDR1-mediated multidrug resistance in mouse L5178Y cells expressing MDR1 assessed as side scatter count measured by cell size ratio at 2 uM after 10 mins by flow cytometry2009Bioorganic & medicinal chemistry, Oct-01, Volume: 17, Issue:19
New potent P-glycoprotein modulators with the cucurbitane scaffold and their synergistic interaction with doxorubicin on resistant cancer cells.
AID1247258Antimalarial activity against Plasmodium berghei NK65 infected in BALB/c mouse assessed as inhibition of parasitemia at 50 mg/kg, po qd for 4 days measured on 5th day after parasite inoculation by Giemsa staining based microscopy relative to control2015European journal of medicinal chemistry, Sep-18, Volume: 102In vivo evaluation of isolated triterpenes and semi-synthetic derivatives as antimalarial agents.
AID455733Reversal of human MDR1-mediated multidrug resistance in mouse L5178Y cells expressing MDR1 assessed as side scatter count measured by cell size ratio at 0.5 uM after 10 mins by flow cytometry2009Bioorganic & medicinal chemistry, Oct-01, Volume: 17, Issue:19
New potent P-glycoprotein modulators with the cucurbitane scaffold and their synergistic interaction with doxorubicin on resistant cancer cells.
AID1247269Antimalarial activity against Plasmodium berghei NK65 infected in BALB/c mouse assessed as mean survival time at 25 mg/kg, sc qd for 4 days (Rvb = 23 +/- 4 days)2015European journal of medicinal chemistry, Sep-18, Volume: 102In vivo evaluation of isolated triterpenes and semi-synthetic derivatives as antimalarial agents.
AID455725Reversal of human MDR1-mediated multidrug resistance in mouse L5178Y cells expressing MDR1 assessed as fluorescence activity ratio at 20 uM after 10 mins by rhodamine-123 exclusion test2009Bioorganic & medicinal chemistry, Oct-01, Volume: 17, Issue:19
New potent P-glycoprotein modulators with the cucurbitane scaffold and their synergistic interaction with doxorubicin on resistant cancer cells.
AID1247262Antimalarial activity against Plasmodium berghei NK65 infected in BALB/c mouse assessed as inhibition of parasitemia at 25 mg/kg, po qd for 4 days measured on 7th day after parasite inoculation by Giemsa staining based microscopy relative to control2015European journal of medicinal chemistry, Sep-18, Volume: 102In vivo evaluation of isolated triterpenes and semi-synthetic derivatives as antimalarial agents.
AID455737Reversal of human MDR1-mediated multidrug resistance in mouse L5178Y cells expressing MDR1 assessed as fluorescence activity ratio at 0.5 uM after 10 mins by rhodamine-123 exclusion test2009Bioorganic & medicinal chemistry, Oct-01, Volume: 17, Issue:19
New potent P-glycoprotein modulators with the cucurbitane scaffold and their synergistic interaction with doxorubicin on resistant cancer cells.
AID1247261Antimalarial activity against Plasmodium berghei NK65 infected in BALB/c mouse assessed as inhibition of parasitemia at 50 mg/kg, po qd for 4 days measured on 7th day after parasite inoculation by Giemsa staining based microscopy relative to control2015European journal of medicinal chemistry, Sep-18, Volume: 102In vivo evaluation of isolated triterpenes and semi-synthetic derivatives as antimalarial agents.
AID1247260Antimalarial activity against Plasmodium berghei NK65 infected in BALB/c mouse assessed as inhibition of parasitemia at 25 mg/kg, sc qd for 4 days measured on 5th day after parasite inoculation by Giemsa staining based microscopy relative to control2015European journal of medicinal chemistry, Sep-18, Volume: 102In vivo evaluation of isolated triterpenes and semi-synthetic derivatives as antimalarial agents.
AID455731Reversal of human MDR1-mediated multidrug resistance in mouse L5178Y cells expressing MDR1 assessed as forward scatter count measured by cell size ratio at 0.5 uM after 10 mins by flow cytometry2009Bioorganic & medicinal chemistry, Oct-01, Volume: 17, Issue:19
New potent P-glycoprotein modulators with the cucurbitane scaffold and their synergistic interaction with doxorubicin on resistant cancer cells.
AID455738Reversal of human MDR1-mediated multidrug resistance in mouse L5178Y cells expressing MDR1 assessed as fluorescence activity ratio at 1 uM after 10 mins by rhodamine-123 exclusion test2009Bioorganic & medicinal chemistry, Oct-01, Volume: 17, Issue:19
New potent P-glycoprotein modulators with the cucurbitane scaffold and their synergistic interaction with doxorubicin on resistant cancer cells.
AID1247265Antimalarial activity against Plasmodium berghei NK65 infected in BALB/c mouse assessed as inhibition of parasitemia at 25 mg/kg, sc qd for 4 days measured on 7th day after parasite inoculation by Giemsa staining based microscopy relative to control2015European journal of medicinal chemistry, Sep-18, Volume: 102In vivo evaluation of isolated triterpenes and semi-synthetic derivatives as antimalarial agents.
AID455734Reversal of human MDR1-mediated multidrug resistance in mouse L5178Y cells expressing MDR1 assessed as side scatter count measured by cell size ratio at 1 uM after 10 mins by flow cytometry2009Bioorganic & medicinal chemistry, Oct-01, Volume: 17, Issue:19
New potent P-glycoprotein modulators with the cucurbitane scaffold and their synergistic interaction with doxorubicin on resistant cancer cells.
AID455736Reversal of human MDR1-mediated multidrug resistance in mouse L5178Y cells expressing MDR1 assessed as mean fluorescence intensity of rhodamine-123 uptake at 1 uM after 10 mins by flow cytometry2009Bioorganic & medicinal chemistry, Oct-01, Volume: 17, Issue:19
New potent P-glycoprotein modulators with the cucurbitane scaffold and their synergistic interaction with doxorubicin on resistant cancer cells.
AID549856Antimalarial activity against chloroquine-resistant Plasmodium falciparum Dd2 infected in erythrocytes after 48 hrs by SYBR Green 1-based fluorescence assay2011Bioorganic & medicinal chemistry, Jan-01, Volume: 19, Issue:1
Karavilagenin C derivatives as antimalarials.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (20.00)29.6817
2010's4 (80.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 13.28

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index13.28 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index5.08 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (13.28)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
verapamil
Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.. verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.. 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.		2.0510aromatic ether;
nitrile;
polyether;
tertiary amino compound
chloroquine
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.. chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.		2.1110aminoquinoline;
organochlorine compound;
secondary amino compound;
tertiary amino compound		anticoronaviral agent;
antimalarial;
antirheumatic drug;
autophagy inhibitor;
dermatologic drug
lucanthone hydrochloride
Schistosomicides: Agents that act systemically to kill adult schistosomes.		2.0710
ConditionIndicatedRelationship StrengthStudiesTrials
Germinoblastoma
[description not available]		02.0510
Lymphoma
A general term for various neoplastic diseases of the lymphoid tissue.		02.0510
Infections, Plasmodium
[description not available]		02.1110
Malaria
A protozoan disease caused in humans by four species of the PLASMODIUM genus: PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; PLASMODIUM OVALE; and PLASMODIUM MALARIAE; and transmitted by the bite of an infected female mosquito of the genus ANOPHELES. Malaria is endemic in parts of Asia, Africa, Central and South America, Oceania, and certain Caribbean islands. It is characterized by extreme exhaustion associated with paroxysms of high FEVER; SWEATING; shaking CHILLS; and ANEMIA. Malaria in ANIMALS is caused by other species of plasmodia.		02.1110