Compounds > jpm 565
Page last updated: 2024-11-08

jpm 565

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

JPM 565: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID644294
CHEMBL ID1242843
MeSH IDM0358530

Synonyms (9)

Synonym
oxiranecarboxylic acid, 3-[[[(1s)-1-[[[2-(4-hydroxyphenyl)ethyl]amino]carbonyl]-3-methylbutyl]amino]carbonyl]-, ethyl ester, (2s,3s)- (9ci)
2-oxiranecarboxylic acid, 3-[[[(1s,2s)-1-[[[2-(4-hydroxyphenyl)ethyl]amino]carbonyl]-2-methylbutyl]amino]carbonyl]-, ethyl ester, (2s,3s)-
cid644294
ethyl (2s,3s)-3-[[(2s)-1-[2-(4-hydroxyphenyl)ethylamino]-3-methyl-1-oxopentan-2-yl]carbamoyl]oxirane-2-carboxylate
CHEMBL1242843
jpm 565
bdbm36334
3-(ethoxycarbonyl)-n-(1-hydroxy-1-{[2-(4-hydroxyphenyl)ethyl]imino}-3-methylpentan-2-yl)oxirane-2-carboximidic acid
DTXSID00949102
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (4)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
LegumainMus musculus (house mouse)IC50 (µMol)1.88000.78001.88002.9800AID1799367
Procathepsin LMus musculus (house mouse)IC50 (µMol)1.88000.25401.33802.9800AID1799367
Cathepsin BMus musculus (house mouse)IC50 (µMol)1.88000.54001.43332.9800AID1799367
Caspase-3 Mus musculus (house mouse)IC50 (µMol)1.88000.78001.88002.9800AID1799367
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Ceullar Components (1)

Processvia Protein(s)Taxonomy
cytosolCaspase-3 Mus musculus (house mouse)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (1)

Assay IDTitleYearJournalArticle
AID1799367Enzyme kinetic assay from Article 10.1021/cb900232a: \\Development of near-infrared fluorophore (NIRF)-labeled activity-based probes for in vivo imaging of legumain.\\2010ACS chemical biology, Feb-19, Volume: 5, Issue:2
Development of near-infrared fluorophore (NIRF)-labeled activity-based probes for in vivo imaging of legumain.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (57.14)29.6817
2010's3 (42.86)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.24

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.24 (24.57)
Research Supply Index2.08 (2.92)
Research Growth Index4.32 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.24)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other7 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
leucine
Leucine: An essential branched-chain amino acid important for hemoglobin formation.. leucine : A branched-chain amino acid that consists of glycine in which one of the hydrogens attached to the alpha-carbon is substituted by an isobutyl group.		3.2760amino acid zwitterion;
L-alpha-amino acid;
leucine;
proteinogenic amino acid;
pyruvate family amino acid		algal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite
e 64
E 64: cysteine protease inhibitor of microbial origin, which inhibits cathepsin B (EC 3.4.22.1) and cathepsin L (EC 3.4.22.-)		210dicarboxylic acid monoamide;
epoxy monocarboxylic acid;
guanidines;
L-leucine derivative;
zwitterion		antimalarial;
antiparasitic agent;
protease inhibitor
vby-825
VBY-825: reversible cathepsin inhibitor		2.0510
dcg 04
DCG 04: E-64 analog; structure in first source		210
ConditionIndicatedRelationship StrengthStudiesTrials
Benign Neoplasms
[description not available]		02.0510
Neoplasms
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.		02.0510
Disease Exacerbation
[description not available]		02.4220
Breast Cancer
[description not available]		02.4620
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.		02.4520
Breast Neoplasms
Tumors or cancer of the human BREAST.		02.4620
Angiogenesis, Pathologic
[description not available]		02.0510
Cancer of Pancreas
[description not available]		02.0510
Invasiveness, Neoplasm
[description not available]		02.0510
Pancreatic Neoplasms
Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).		02.0510
Bone Cancer
[description not available]		02.0710
Experimental Mammary Neoplasms
[description not available]		02.0710
Bone Neoplasms
Tumors or cancer located in bone tissue or specific BONES.		02.0710
Metastase
[description not available]		0210
Neoplasm Metastasis
The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.		0210
Cancer of Skin
[description not available]		0210
Skin Neoplasms
Tumors or cancer of the SKIN.		0210