isoerianin and Breast-Neoplasms

isoerianin has been researched along with Breast-Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for isoerianin and Breast-Neoplasms

Article	Year
Design and synthesis of silicon-containing tubulin polymerization inhibitors: replacement of the ethylene moiety of combretastatin A-4 with a silicon linker. Bioorganic & medicinal chemistry, 2013, Dec-01, Volume: 21, Issue:23 Silicon-containing combretastatin analogs were designed, synthesized and evaluated for stability and biological activities. Among them, compound 31 exhibited strong tubulin polymerization-inhibitory activity and very potent tumor cell growth-inhibitory activity (IC50=0.007 μM) in MCF-7 cell proliferation assay. This compound also potently inhibited [(3)H]colchicine binding (90.7% inhibition at 3 μM). These activities were comparable to those of combretastatin A-4 (CA-4) (1). In addition, compound 31 was physico-chemically more stable than 1. These results suggest that a silicon linker can act as a bioisoster of a cis carbon-carbon double bond. Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Colchicine; Drug Design; Female; Humans; Silicon; Stilbenes; Tubulin; Tubulin Modulators	2013

Article

Year

Design and synthesis of silicon-containing tubulin polymerization inhibitors: replacement of the ethylene moiety of combretastatin A-4 with a silicon linker.

Bioorganic & medicinal chemistry, 2013, Dec-01, Volume: 21, Issue:23

Silicon-containing combretastatin analogs were designed, synthesized and evaluated for stability and biological activities. Among them, compound 31 exhibited strong tubulin polymerization-inhibitory activity and very potent tumor cell growth-inhibitory activity (IC50=0.007 μM) in MCF-7 cell proliferation assay. This compound also potently inhibited [(3)H]colchicine binding (90.7% inhibition at 3 μM). These activities were comparable to those of combretastatin A-4 (CA-4) (1). In addition, compound 31 was physico-chemically more stable than 1. These results suggest that a silicon linker can act as a bioisoster of a cis carbon-carbon double bond.

Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Colchicine; Drug Design; Female; Humans; Silicon; Stilbenes; Tubulin; Tubulin Modulators

2013