Compounds > icogenin
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icogenin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

Icogenin: a cytotoxic steroidal saponin isolated from Dracaena draco; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

FloraRankFlora DefinitionFamilyFamily Definition
DracaenagenusA plant genus of the family Asparagaceae. The common name of dragon's blood is also used for CROTON and Daemonorops (ARECACEAE).[MeSH]AsparagaceaeA family of flowering subshrubs and shrubs in the class Magnoliopsida.[MeSH]

Cross-References

ID SourceID
PubMed CID44410621
CHEMBL ID427949
MeSH IDM0481198

Synonyms (2)

Synonym
CHEMBL427949
icogenin

Research Excerpts

Overview

Icogenin was found to be a cytotoxic compound IC(50) 2.6+/-0.9microM at 72h, with growth inhibition caused by the induction of apoptosis.

ExcerptReferenceRelevance
"Icogenin was found to be a cytotoxic compound IC(50) 2.6+/-0.9microM at 72h, with growth inhibition caused by the induction of apoptosis, as determined by microscopy of nuclear changes and the fragmentation of poly(ADP-ribose) polymerase-1."( Icogenin, a new cytotoxic steroidal saponin isolated from Dracaena draco.
Bermejo, J; Estévez, F; Hernández, JC; León, F; Quintana, J, 2004)		2.49
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (9)

Assay IDTitleYearJournalArticle
AID263842Cytotoxicity against human A431 cells by MTT assay2006Bioorganic & medicinal chemistry letters, May-01, Volume: 16, Issue:9
Synthesis and antitumor activity of icogenin and its analogue.
AID263838Cytotoxicity against human PC3M cells by MTT assay2006Bioorganic & medicinal chemistry letters, May-01, Volume: 16, Issue:9
Synthesis and antitumor activity of icogenin and its analogue.
AID263843Cytotoxicity against human BEL-7402 cells by MTT assay2006Bioorganic & medicinal chemistry letters, May-01, Volume: 16, Issue:9
Synthesis and antitumor activity of icogenin and its analogue.
AID263840Cytotoxicity against human HCT8 cells by MTT assay2006Bioorganic & medicinal chemistry letters, May-01, Volume: 16, Issue:9
Synthesis and antitumor activity of icogenin and its analogue.
AID648751Cytotoxicity against human HL60 cells2012European journal of medicinal chemistry, May, Volume: 51Synthesis and antitumor activity of 5,6-dihydro-17-hydroxy icogenin analogs.
AID263841Cytotoxicity against human BGC823 cells by MTT assay2006Bioorganic & medicinal chemistry letters, May-01, Volume: 16, Issue:9
Synthesis and antitumor activity of icogenin and its analogue.
AID263836Cytotoxicity against human KETR3 cells by MTT assay2006Bioorganic & medicinal chemistry letters, May-01, Volume: 16, Issue:9
Synthesis and antitumor activity of icogenin and its analogue.
AID263839Cytotoxicity against human H460 cells by MTT assay2006Bioorganic & medicinal chemistry letters, May-01, Volume: 16, Issue:9
Synthesis and antitumor activity of icogenin and its analogue.
AID263837Cytotoxicity against human PANC1 cells by MTT assay2006Bioorganic & medicinal chemistry letters, May-01, Volume: 16, Issue:9
Synthesis and antitumor activity of icogenin and its analogue.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (66.67)29.6817
2010's2 (33.33)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
squalamine
squalamine: from dogfish shark Squalus acanthias; structure given in first source		2.1510bile acid
dioscin
[no description available]		2.0710hexacyclic triterpenoid;
spiroketal;
spirostanyl glycoside;
trisaccharide derivative		anti-inflammatory agent;
antifungal agent;
antineoplastic agent;
antiviral agent;
apoptosis inducer;
EC 1.14.18.1 (tyrosinase) inhibitor;
hepatoprotective agent;
metabolite
beta-escin
[no description available]		3.360
ConditionIndicatedRelationship StrengthStudiesTrials
Cancer of Pancreas
[description not available]		02.0510
Invasiveness, Neoplasm
[description not available]		02.0510
Pancreatic Neoplasms
Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).		02.0510