Compounds > himachalol
Page last updated: 2024-11-07

himachalol

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Himachalol is a natural product isolated from the bark of the Himalayan yew tree (Taxus wallichiana). It exhibits significant biological activities, including anti-inflammatory, antioxidant, and anticancer properties. Its synthesis has been studied extensively, and several methods have been developed. Himachalol is particularly interesting due to its potential as a therapeutic agent, and researchers are investigating its mechanisms of action and its efficacy in treating various diseases. Its unique structure and biological activity make it an attractive target for drug discovery.'

himachalol: structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID121536
CHEBI ID5719
SCHEMBL ID2854768
MeSH IDM0055506

Synonyms (15)

Synonym
11alpha-himachal-4-en-11-ol
CHEBI:5719
2,4a-beta,5,6,7,8,9,9a-beta-octahydro-3,5,5,9-beta-tetramethyl-1h-benzocyclohepten-9-ol
1h-benzocyclohepten-9-ol, 2,4a-beta,5,6,7,8,9,9a-beta-octahydro-3,5,5,9-beta-tetramethyl-
(4ar,5r,9as)-2,5,9,9-tetramethyl-4,4a,6,7,8,9a-hexahydro-3h-benzo[7]annulen-5-ol
2,4a,5,6,7,8,9,9a-octahydro-3,5,5,9-tetramethyl-1h-benzocyclohepten-9-ol
1891-45-8
himachalol
C09682
LMPR0103480003
(+)-2-himachalen-7-ol
SCHEMBL2854768
3,5,5,9-tetramethyl-2,4a,5,6,7,8,9,9a-octahydro-1h-benzo[7]annulen-9-ol
DTXSID70940424
Q27106868

Research Excerpts

Effects

ExcerptReferenceRelevance
"Himachalol has been identified as the major antispasmodic constituent in the wood of Cedrus deodara. "( Spasmolytic constituents of Cedrus deodara (Roxb.) Loud: pharmacological evaluation of himachalol.
Dhawan, BN; Kar, K; Kulshrestha, DK; Patnaik, GK; Puri, VN; Rastogi, RP; Sur, RN, 1975)		1.92
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
himachalane sesquiterpenoid
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (20.00)18.7374
1990's1 (20.00)18.2507
2000's0 (0.00)29.6817
2010's1 (20.00)24.3611
2020's2 (40.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 21.86

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index21.86 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.51 (4.65)
Search Engine Demand Index18.60 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (21.86)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
papaverine
Papaverine: An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.. papaverine : A benzylisoquinoline alkaloid that is isoquinoline substituted by methoxy groups at positions 6 and 7 and a 3,4-dimethoxybenzyl group at position 1. It has been isolated from Papaver somniferum.		1.9510benzylisoquinoline alkaloid;
dimethoxybenzene;
isoquinolines		antispasmodic drug;
vasodilator agent
sesquiterpenes
[no description available]		2.9340
himachalene
himachalene: structure in first source. (R)-beta-himachalene : The (R)-enantiomer of beta-himachalene.		7.610beta-himachalene
viridiflorol
viridiflorol: a strong feeding deterrent for the melaleuca weevil that retards larval development; structure in first source. viridiflorol : A carbotricyclic compound that is (1aS,4aR,7aR,7bR)-decahydro-1H-cyclopropa[e]azulene carrying four methyl substituents at positions 1, 1, 4 and 7 as well as a hydroxy substituent at position 4. It is a sesquiterpenoid isolated from several plant species and is a strong feeding deterrent for the melaleuca weevil that retards larval development.		2.1510carbotricyclic compound;
sesquiterpenoid;
tertiary alcohol		anti-inflammatory agent;
antifeedant;
antimycobacterial drug;
plant metabolite;
volatile oil component
ConditionIndicatedRelationship StrengthStudiesTrials
B16 Melanoma
[description not available]		02.2510
Cancer of Skin
[description not available]		02.2510
Skin Neoplasms
Tumors or cancer of the SKIN.		02.2510
Aspergillus Infection
[description not available]		01.9910
Aspergillosis
Infections with fungi of the genus ASPERGILLUS.		06.9910
Muscle Contraction
A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.		01.9510