Compounds > himachalol
Page last updated: 2024-09-03

himachalol and papaverine

himachalol has been researched along with papaverine in 1 studies

*Papaverine: An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels. [MeSH]

*Papaverine: An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels. [MeSH]

Compound Research Comparison

Studies
(himachalol)		Trials
(himachalol)		Recent Studies (post-2010)
(himachalol)		Studies
(papaverine)		Trials
(papaverine)		Recent Studies (post-2010) (papaverine)
6036,027305355

Protein Interaction Comparison

ProteinTaxonomyhimachalol (IC50)papaverine (IC50)
Chain A, cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10ARattus norvegicus (Norway rat)0.076
cGMP-dependent 3',5'-cyclic phosphodiesteraseHomo sapiens (human)2.3
cGMP-specific 3',5'-cyclic phosphodiesteraseHomo sapiens (human)8.8
3',5'-cyclic-AMP phosphodiesterase Sus scrofa (pig)1.7
Bile salt export pumpHomo sapiens (human)10
cAMP-specific 3',5'-cyclic phosphodiesterase 4AHomo sapiens (human)1.6
Cytochrome P450 2C19Homo sapiens (human)0.762
Serine hydroxymethyltransferase, mitochondrialHomo sapiens (human)2.6915
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1AHomo sapiens (human)9
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1BHomo sapiens (human)9
cAMP-specific 3',5'-cyclic phosphodiesterase 4DHomo sapiens (human)1.4
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)7.2444
cGMP-inhibited 3',5'-cyclic phosphodiesterase BHomo sapiens (human)1.03
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1CHomo sapiens (human)9
cGMP-inhibited 3',5'-cyclic phosphodiesterase AHomo sapiens (human)0.697
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Rattus norvegicus (Norway rat)0.036
Phosphodiesterase Sus scrofa (pig)0.62
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10AHomo sapiens (human)0.07

Research

Studies (1)

TimeframeStudies, this research(%)All Research%
pre-19901 (100.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Dhawan, BN; Kar, K; Kulshrestha, DK; Patnaik, GK; Puri, VN; Rastogi, RP; Sur, RN1

Other Studies

1 other study(ies) available for himachalol and papaverine

ArticleYear
Spasmolytic constituents of Cedrus deodara (Roxb.) Loud: pharmacological evaluation of himachalol.
    Journal of pharmaceutical sciences, 1975, Volume: 64, Issue:2

    Topics: Animals; Benzocycloheptenes; Blood Circulation; Blood Pressure; Bronchi; Cattle; Charcoal; Dose-Response Relationship, Drug; Female; Gastrointestinal Motility; Guinea Pigs; Heart Atria; Histamine Release; Ileum; In Vitro Techniques; Jejunum; Lethal Dose 50; Male; Muscle Contraction; Nictitating Membrane; Papaverine; Parasympatholytics; Plant Extracts; Plants, Medicinal; Polycyclic Sesquiterpenes; Rabbits; Rats; Seminal Vesicles; Sesquiterpenes; Trachea; Uterus

1975