Compounds > hc blue no. 2
Page last updated: 2024-11-06

hc blue no. 2

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID36383
CHEMBL ID1561876
CHEBI ID82472
SCHEMBL ID109266
MeSH IDM0152410

Synonyms (70)

Synonym
hc blue no. 2
2,2'-({4-[(2-hydroxyethyl)amino]-3-nitrophenyl}imino)diethanol
33229-34-4
NCGC00091249-01
hc blue 2
p-phenylenediamine, 3-nitro-n(sup 1),n(sup 1),n(sup 4)-tris(2-hydroxyethyl)-
einecs 251-410-3
nci-c54897
hc blue #2
brn 2148848
n1,n4,n4-tris(2-hydroxyethyl)-2-nitro-p-phenylenediamine
3-nitro-n(sup 1),n(sup 1),n(sup 4)-tris(2-hydroxyethyl)-
ethanol, 2,2'-((4-((2-hydroxyethyl)amino)-3-nitrophenyl)imino)bis-
ccris 1358
hsdb 4213
ethanol, 2,2'-((4-((2-hydroxyethyl)amino)-3-nitrophenyl)imino)di-
2,2'-((4-((2-hydroxyethyl)amino)-3-nitrophenyl)imino)bis(ethanol)
n(sup 1),n(sup 4),n(sup 4)-tris(2-hydroxyethyl)-2-nitro-para-phenylenediamine
2,2'-[4-(2-hydroxyethylamino)-3-nitrophenylimino]diethanol, 98%
NCGC00091249-02
2-[4-[bis(2-hydroxyethyl)amino]-2-nitroanilino]ethanol
NCGC00091249-03
NCGC00091249-04
n1,n4,n4-tris(2-hydroxyethyl)-2-nitro-1,4-phenylenediamine
T2787
2,2'-[4-(2-hydroxyethylamino)-3-nitrophenylimino]diethanol
2,2'-[[4-[(2-hydroxyethyl)amino]-3-nitrophenyl]imino]bis-ethanol
C19429
NCGC00256575-01
dtxcid80193
tox21_302947
dtxsid6020193 ,
cas-33229-34-4
NCGC00259806-01
tox21_202257
2-[[4-[bis(2-hydroxyethyl)amino]-2-nitro-phenyl]amino]ethanol
A821680
n,n',n'-tris(2-hydroxyethyl)-2-nitro-p-phenylenediamine
2,2'-((4-((2-hydroxyethyl)amino)-3-nitrophenyl)azanediyl)diethanol
2,2'-[[4-[(2-hydroxyethyl)amino]-3-nitrophenyl]imino]bis[ethanol]
n1,n4,n4-tris(2'-hydroxyethyl)-2-nitro-p-phenylenediamine
unii-6c0el1931v
ec 251-410-3
6c0el1931v ,
FT-0616254
AKOS015895598
SCHEMBL109266
colorex hcb2
hc blue no. 2 [inci]
covariane bleu w 6122 lp
hc blue no.2 [hsdb]
jarocol blue 2
2,2'-(4-(2-hydroxyethylamino)-3-nitrophenylimino)diethanol
hc blue no. 2 [iarc]
covarine blue w 6122
CHEBI:82472 ,
CHEMBL1561876
mfcd00071762
AC-8293
J-019100
Q27155970
3-nitro-4-[n-(2-hydroxyethyl)amino]-n,n-bis(2-ydroxyethyl)aniline
AS-11935
2,2'-(4-(2-hydroxyethylamino)-3-nitrophenylazanediyl)diethanol
2-(4-(bis(2-hydroxyethyl)amino)-2-nitroanilino)ethanol
hc blue no.2
CS-W012231
hc azul 2
hc blu 2
hc bleu 2
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
C-nitro compoundA nitro compound having the nitro group (-NO2) attached to a carbon atom.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (28)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Chain A, TYROSYL-DNA PHOSPHODIESTERASEHomo sapiens (human)Potency5.62340.004023.8416100.0000AID485290
LuciferasePhotinus pyralis (common eastern firefly)Potency34.06320.007215.758889.3584AID1224835
interleukin 8Homo sapiens (human)Potency42.16320.047349.480674.9780AID651758
acetylcholinesteraseHomo sapiens (human)Potency25.14350.002541.796015,848.9004AID1347399
RAR-related orphan receptor gammaMus musculus (house mouse)Potency40.65290.006038.004119,952.5996AID1159521; AID1159523
AR proteinHomo sapiens (human)Potency44.87150.000221.22318,912.5098AID1259243; AID1259247; AID743042; AID743054
aldehyde dehydrogenase 1 family, member A1Homo sapiens (human)Potency39.81070.011212.4002100.0000AID1030
thyroid stimulating hormone receptorHomo sapiens (human)Potency10.00000.001318.074339.8107AID926; AID938
nuclear receptor subfamily 1, group I, member 3Homo sapiens (human)Potency52.40090.001022.650876.6163AID1224838; AID1224839; AID1224893
glucocorticoid receptor [Homo sapiens]Homo sapiens (human)Potency4.46680.000214.376460.0339AID588532
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency36.47680.003041.611522,387.1992AID1159552; AID1159553; AID1159555
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency32.70360.001530.607315,848.9004AID1224841; AID1224842; AID1224848; AID1224849; AID1259401; AID1259403
estrogen nuclear receptor alphaHomo sapiens (human)Potency38.75560.000229.305416,493.5996AID1259244; AID1259248; AID743069; AID743075; AID743079; AID743080; AID743091
peroxisome proliferator activated receptor gammaHomo sapiens (human)Potency27.43420.001019.414170.9645AID588536; AID743191
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_aHomo sapiens (human)Potency67.40410.001723.839378.1014AID743083
thyroid stimulating hormone receptorHomo sapiens (human)Potency27.71400.001628.015177.1139AID1224843; AID1224895; AID1259385; AID1259393; AID1259395
activating transcription factor 6Homo sapiens (human)Potency9.75210.143427.612159.8106AID1159516
Histone H2A.xCricetulus griseus (Chinese hamster)Potency33.41110.039147.5451146.8240AID1224845; AID1224896
tumor necrosis factorHomo sapiens (human)Potency47.30790.375823.492842.1632AID651757
thyroid hormone receptor beta isoform 2Rattus norvegicus (Norway rat)Potency59.69810.000323.4451159.6830AID743065; AID743067
histone deacetylase 9 isoform 3Homo sapiens (human)Potency33.76010.037617.082361.1927AID1259364; AID1259388
heat shock protein beta-1Homo sapiens (human)Potency60.48430.042027.378961.6448AID743210; AID743228
nuclear factor erythroid 2-related factor 2 isoform 1Homo sapiens (human)Potency50.97080.000627.21521,122.0200AID720636; AID743202
Polyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)Potency19.95260.316212.765731.6228AID881
Voltage-dependent calcium channel gamma-2 subunitMus musculus (house mouse)Potency27.27820.001557.789015,848.9004AID1259244
Glutamate receptor 2Rattus norvegicus (Norway rat)Potency27.27820.001551.739315,848.9004AID1259244
Histamine H2 receptorCavia porcellus (domestic guinea pig)Potency19.95260.00638.235039.8107AID881
Inositol monophosphatase 1Rattus norvegicus (Norway rat)Potency11.22021.000010.475628.1838AID1457
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (21)

Processvia Protein(s)Taxonomy
lipid metabolic processPolyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)
phospholipid metabolic processPolyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)
apoptotic processPolyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)
negative regulation of cell population proliferationPolyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)
positive regulation of macrophage derived foam cell differentiationPolyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)
arachidonic acid metabolic processPolyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)
negative regulation of cell migrationPolyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)
prostate gland developmentPolyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)
regulation of epithelial cell differentiationPolyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)
positive regulation of chemokine productionPolyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)
positive regulation of peroxisome proliferator activated receptor signaling pathwayPolyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)
positive regulation of keratinocyte differentiationPolyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)
negative regulation of cell cyclePolyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)
negative regulation of growthPolyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)
hepoxilin biosynthetic processPolyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)
endocannabinoid signaling pathwayPolyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)
cannabinoid biosynthetic processPolyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)
lipoxin A4 biosynthetic processPolyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)
linoleic acid metabolic processPolyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)
lipid oxidationPolyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)
lipoxygenase pathwayPolyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (8)

Processvia Protein(s)Taxonomy
iron ion bindingPolyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)
calcium ion bindingPolyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)
protein bindingPolyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)
lipid bindingPolyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)
linoleate 13S-lipoxygenase activityPolyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)
arachidonate 8(S)-lipoxygenase activityPolyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)
arachidonate 15-lipoxygenase activityPolyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)
linoleate 9S-lipoxygenase activityPolyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (8)

Processvia Protein(s)Taxonomy
nucleusPolyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)
cytosolPolyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)
cytoskeletonPolyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)
plasma membranePolyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)
adherens junctionPolyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)
focal adhesionPolyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)
membranePolyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)
extracellular exosomePolyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)
plasma membraneGlutamate receptor 2Rattus norvegicus (Norway rat)
[Information is prepared from geneontology information from the June-17-2024 release]

Research

Studies (8)

TimeframeStudies, This Drug (%)All Drugs %
pre-19902 (25.00)18.7374
1990's6 (75.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 32.23

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index32.23 (24.57)
Research Supply Index2.20 (2.92)
Research Growth Index4.76 (4.65)
Search Engine Demand Index39.34 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (32.23)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (12.50%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other7 (87.50%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
n-methylamino-2-nitro-4-n',n'-bis(2-hydroxyethyl)aminobenzene
N-methylamino-2-nitro-4-N',N'-bis(2-hydroxyethyl)aminobenzene: structure		3.3670C-nitro compound
ConditionIndicatedRelationship StrengthStudiesTrials
Germinoblastoma
[description not available]		01.9710
Lymphoma
A general term for various neoplastic diseases of the lymphoid tissue.		06.9710
Abnormalities, Autosome
[description not available]		02.3820
Experimental Neoplasms
[description not available]		02.3720
Experimental Hepatoma
[description not available]		01.9710